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Protein Tyrosine Kinase
VEGF
   
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VEGF Interactive Pathway: Src
 
Antibodies
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Anti-SLAP-2 Rabbit pAb IB, IP human, mouse ST1037
PhosphoDetect™ Anti-Src Family (pTyr416) Rabbit pAb FC, FFS, IB, IC, PS human, mouse PK1109
PhosphoDetect™ Anti-Src (pTyr418) Rabbit pAb FS, IB, PS chicken, human, mouse 569373
PhosphoDetect™ Anti-Src (pTyr529) Rabbit pAb IB, IH chicken, human, mouse, rat 569374
Anti-v-Src (Ab-1) Mouse mAb (327) IB, IP, NOT FS, NOT IF, NOT PS human, mouse, rat OP07
Anti-v-Src (Ab-1) Mouse mAb (327) IB, IP, NOT FS, NOT IF, NOT PS human, mouse, rat OP07L
Anti-v-Src (Ab-1) Mouse mAb (327) IB, IP, NOT FS, NOT IF, NOT PS human, mouse, rat OP07T
Anti-v-Src (Ab-1) Mouse mAb (327) Agarose Conjugate IB, IP human, mouse, rat OP07A
PhosphoDetect™ Anti-Src (pTyr418) Mouse mAb (9A6) ELISA, IB, IC human, mouse, rat 569372
 
Assay Kits
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Src ELISA Kit CBA027
IP-Activity™ Src Kit CBA056
PhosphoDetect™ Src (pTyr 418) ELISA Kit CBA028
 
  Inhibitors
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Src Family Protein Tyrosine Kinase Inhibitor Set 567816
Src Kinase Inhibitor I 567805
Src Kinase Inhibitor II 567806
 
  Peptides/Substrates
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Src Peptide 521-533 567800
Src Peptide 521-533, Phosphorylated 567801
Src SH2 Domain Inhibitor Peptide 567815
Src Substrate II 567812
Src Substrate II, Phosphorylated 567814
 
  Protein/Enzymes
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Src1, GST-Fusion Protein, Active, Human, Recombinant, S. frugiperda 539688
SrcN1, Human, Recombinant, S. frugiperda 567820
 
Additional Information
 
 
 
 

Protein : SRC

Name SRC
Description Rous sarcoma oncogene
Owner Public
URN urn:agi-llid:6714
Connectivity 669
Notes This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Hugo ID 11283
Microarray ID 1373124_at
1368830_at
rc_aa956919_at
A_43_P12708
99388_at
msa.1184.0_at
A_51_P426214
A_52_P600547
AF077754
K03218
213324_at
221281_at
221284_s_at
1558210_at
1558211_s_at
1565080_at
1565082_x_at
1938_at
38904_at
K03218_at
rc_aa402622_at
A_23_P308600
A_23_P252316
A_14_P101866
A_14_P105797
A_23_P308603
A_14_P111562
M133
655
OH7842
OR2695
RT167
rc_aa875131_at
1387352_at
1389030_a_at
rc_AA943307_at
rc_AA943307_g_at
rc_AI011267_at
rc_AI179933_at
NM_031977
108711_at
1423240_at
1450918_s_at
NM_009271
I_961362
NM_005417.2
GenBank ID AAA40135
AAA60584
AAC29427
AAH11566
AAH51270
AF077754
AF272982
AK024281
AK091756
AL133293
BAB14871
BC011566
BC051270
CAA26485
CAC10573
CAC34523
CAI22921
K03218
NC_000020
NM_005417
NM_198291
NP_005408
NP_938033
NT_011362
NT_086910
P12931
X02647
Z18364
AAH39953
AJ312258
AJ312259
AJ312260
AJ312261
AJ312262
AJ312263
AJ312264
AJ313104
AJ313176
AJ313177
AK017629
AK146056
AK182969
AK189521
AK190301
AK192339
AK201096
BAE26865
BC039953
M17031
NC_000068
NM_001025395
NM_009271
NP_001020566
NP_033297
NT_039207
P05480
AAD24180
AAF80335
AAZ23848
AAZ23849
AF130457
AF157016
DQ120509
DQ120510
NC_005102
NM_031977
NP_114183
NW_047659
Q9WUD9
51475129
38202215
4885609
38202216
38202217
51475242
3406614
3406615
9662889
10635153
13374724
56205021
338458
338460
36588
1848077
10764419
10436622
10436623
21750203
15079459
15079460
30411070
55930980
296888
125711
AK051808
AK052743
26094768
26095353
NW_043651
51712816
6678128
6678129
14349138
14349139
14349140
14349141
14349142
14349143
14349144
14331041
14488162
14488163
25059026
25059027
201056
201057
34860450
14010834
14010835
4574718
4574719
8885997
8885998
NT_039210
125715
Chromosome position 2 89.0 cM
3q42
20q12-q13
GO ID GO:0004672
GO:0016740
GO:0008151
GO:0006468
GO:0007242
GO:0000074
GO:0005622
GO:0005070
GO:0007172
GO:0007243
GO:0007048
0000074
0004672
0004674
0005622
0007242
0016301
0050875
0000166
0004713
0005070
0005515
0005524
0006468
0007172
0007243
0009986
0016740
GO:0016301
GO:0004713
GO:0005524
GO:0004674
GO:0005515
Alias Src
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
D230002P11Rik
tyrosine kinase pp60c-src
tyrosine-protein kinase SRC-1
SRC1
SRC protein tyrosine kinase
SRC protein kinase
Protooncogene SRC, Rous sarcoma
Proto-oncogene tyrosine-protein kinase SRC
Rous sarcoma oncogene
tyrosine protein kinase pp60-c-src
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
SRC I
tyrosine protein kinase SRC-1
SRC-1 kinase
AW259666
C-SRC
v-Src
SRC SH2-domain
SRC SH3-domain
asv
Schmidt-Ruppin A-2) viral oncogene homolog
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
P60-SRC
expressed sequence AW259666
RIKEN cDNA D230002P11 gene
Organism Homo sapiens
Rattus norvegicus
Mus musculus
Human
MedLine Reference 12493773
9020193
9924018
11274221
11826110
12466851
12808090
14636584
15062102
12007793
12488346
LocusLink ID 320779
6714
83805
20779
99351
FunctionalClass kinase
protein kinase
protein serine/threonine kinase
ATP binding
SH3/SH2 adaptor
nucleotide binding
protein binding
protein-tyrosine kinase
transferase
RGD ID 620795
Hugo Symbol SRC
Unigene ID Rn.112600
Mm.22845
Hs.195659
Mm.130287
Hs.436015
Rn.2801
Hs.198298
Keyword protein serine/threonine kinase
cytoskeleton
oncogene
activated blood coagulation factor XIV
ccaat-binding transcription factor
sh-3 domain
sh-2 domain
cell matrix contact
GEF
receptor protein tyrosine kinase
plasma membrane
protein tyrosine kinase
PKC
steroid hormone receptor
histone acetyltransferase
5.4.2.-
protein tyrosine kinase activity
histone acetyltransferase activity
phosphotransferase
RNA
cell-matrix contact
nuclei
DNA
nucleus
receptor tyrosine kinase
GO Cellular Component cell surface
intracellular
GO Molecular Function kinase activity
protein-tyrosine kinase activity
ATP binding
protein serine/threonine kinase activity
protein binding
protein kinase activity
transferase activity
SH3/SH2 adaptor protein activity
protein tyrosine kinase activity
ATP binding activity
protein binding activity
Cell Localization Cytoplasm
Plasma membrane
Pathway Erk-PI3K in Collagen Binding
ACH-R in apoptosis
MAPK-ERK in Growth and Differentiation
Integrin Signaling
G-protein Coupled Receptor signaling
PDGFRB
PDGFRA
integrin alpha3beta1
integrin alpha2beta1
integrin alpha1beta1
IL11
HGF
Growth Hormone
EPHB2
EPHA4
EPHA3
EGF
ACVRL1 -> MADH2 signalling pathway
TNFRSF11A -> JUN signalling pathway
NOTCH1 -> NFKB2 signalling pathway
NOTCH1 -> LEF1 signalling pathway
NOTCH1 -> HEY1 signalling pathway
NOTCH1 -> HEY2 signalling pathway
NOTCH4 -> HEY1 signalling pathway
NTRK1 -> MYC signalling pathway
NTRK1 -> MYCN signalling pathway
NTRK1 -> RUNX1 signalling pathway
NTRK1 -> FOXO1A signalling pathway
NTRK1 -> FOXO3A signalling pathway
NTRK1 -> FOS signalling pathway
NTRK1 -> STAT5A signalling pathway
NTRK1 -> CREB1 signalling pathway
NTRK1 -> CTNNB1 signalling pathway
NTRK1 -> MADH3 signalling pathway
OPRD1 -> STAT3 signalling pathway
OPRM1 -> JUNB signalling pathway
TGFBR1 -> MADH4 signalling pathway
TLR2 -> MHC2TA signalling pathway
TNFRSF1A -> FOS signalling pathway
TNFRSF1A -> CREB1 signalling pathway
TNFRSF1A -> RELA signalling pathway
TNFRSF1B -> STAT1 signalling pathway
TNFRSF1B -> CREB1 signalling pathway
ADORA1 -> FOS signalling pathway
ADRA1B -> SRF signalling pathway
ADRA1B -> STAT3 signalling pathway
ADRB2 -> STAT3 signalling pathway
ADRB2 -> CREB1 signalling pathway
AGTR2 -> MYC signalling pathway
AGTR2 -> TP53 signalling pathway
AGTR2 -> JUN signalling pathway
AGTR2 -> FOS signalling pathway
AGTR2 -> PAX2 signalling pathway
AGTR2 -> CREB1 signalling pathway
VCAM1 -> RELA signalling pathway
ICAM1 -> NFKB1 signalling pathway
ICAM1 -> ETS1 signalling pathway
ICAM1 -> FOS signalling pathway
ICAM1 -> STAT1 signalling pathway
PTPRU -> CTNNB1 signalling pathway
IFNAR1 -> CDX2 signalling pathway
IGF1R -> ID2 signalling pathway
IGF1R -> FOXO1A signalling pathway
IGF2R -> ELF4 signalling pathway
ITGAM -> RELA signalling pathway
KDR -> HIF1A signalling pathway
KDR -> HSPCA signalling pathway
KDR -> ATF1 signalling pathway
KDR -> ETS1 signalling pathway
KDR -> STAT1 signalling pathway
KDR -> STAT6 signalling pathway
KDR -> CTNNB1 signalling pathway
KDR -> CTNND1 signalling pathway
KDR -> EGR3 signalling pathway
KIT -> HSPCA signalling pathway
KIT -> MITF signalling pathway
SEMA6B -> FOS signalling pathway
CD4 -> STAT1 signalling pathway
CD4 -> STAT6 signalling pathway
CD14 -> ICSBP1 signalling pathway
CD28 -> BCL6 signalling pathway
CD28 -> FOS signalling pathway
CD28 -> STAT1 signalling pathway
CD28 -> STAT6 signalling pathway
CD28 -> TCF3 signalling pathway
CD28 -> ATF2 signalling pathway
CD28 -> CREBBP signalling pathway
CD28 -> REL signalling pathway
CD28 -> RELA signalling pathway
CD28 -> EGR2 signalling pathway
CD38 -> MYBL1 signalling pathway
TNFRSF5 -> ICSBP1 signalling pathway
TNFRSF5 -> JUNB signalling pathway
TNFRSF5 -> E2F1 signalling pathway
KLRA1 -> CTNNB1 signalling pathway
EPHA3 -> STAT5A signalling pathway
EPHA3 -> ELF1 signalling pathway
EPHA4 -> JUN signalling pathway
EPOR -> FOS signalling pathway
ERBB2 -> HSPCA signalling pathway
ERBB2 -> EP300 signalling pathway
ERBB2 -> FOXO3A signalling pathway
ERBB2 -> STAT5A signalling pathway
ERBB2 -> STAT5B signalling pathway
ERBB4 -> STAT5B signalling pathway
F2R -> HSPCA signalling pathway
FCGR2B -> GATA4 signalling pathway
FGFR1 -> JUN signalling pathway
FGFR1 -> STAT1 signalling pathway
FGFR1 -> STAT3 signalling pathway
FGFR1 -> STAT5A signalling pathway
FGFR1 -> CEBPA signalling pathway
FGFR1 -> CREB1 signalling pathway
FGFR1 -> CREBBP signalling pathway
FGFR3 -> STAT1 signalling pathway
FGFR3 -> STAT5A signalling pathway
FLT3 -> HSPCA signalling pathway
GCGR -> TP53 signalling pathway
SSTR2 -> TP53 signalling pathway
SSTR2 -> JUN signalling pathway
SSTR2 -> ATF2 signalling pathway
GPR9 -> RELA signalling pathway
GRIA2 -> FOS signalling pathway
GRIA3 -> FOS signalling pathway
GRIN1 -> FOS signalling pathway
GRIN1 -> CREB1 signalling pathway
GRM1 -> CREB1 signalling pathway
GRM2 -> FOS signalling pathway
GRM5 -> FOS signalling pathway
GRM5 -> CREB1 signalling pathway
GRM5 -> EGR1 signalling pathway
PDGFRA -> STAT1 signalling pathway
PDGFRA -> STAT3 signalling pathway
PECAM1 -> SP1 signalling pathway
PECAM1 -> CTNNB1 signalling pathway
PECAM1 -> RBL2 signalling pathway
CCR4 -> CNOT4 signalling pathway
CNR2 -> EGR1 signalling pathway
PLAUR -> SMARCA4 signalling pathway
CSF3R -> SPI1 signalling pathway
PRLR -> VAV1 signalling pathway
PRLR -> CTNNB1 signalling pathway
PTGDR -> CTNNB1 signalling pathway
PTPRA -> TEAD1 signalling pathway
PTPRC -> NFATC2 signalling pathway
PTPRC -> STAT3 signalling pathway
PTPRC -> STAT6 signalling pathway
PVRL1 -> CTNNB1 signalling pathway
DRD1 -> CTNNB1 signalling pathway
DRD2 -> JUN signalling pathway
DRD2 -> CREB1 signalling pathway
DRD2 -> CTNNB1 signalling pathway
DRD2 -> EGR1 signalling pathway
RET -> HSF1 signalling pathway
RET -> JUN signalling pathway
RET -> STAT3 signalling pathway
RET -> CREB1 signalling pathway
EGFR -> HSPCA signalling pathway
EGFR -> JUN signalling pathway
EGFR -> STAT1 signalling pathway
EGFR -> STAT5A signalling pathway
EGFR -> STAT5B signalling pathway
EGFR -> CREB1 signalling pathway
EGFR -> CTNNB1 signalling pathway
EGFR -> CTNND1 signalling pathway
M6PR -> ELF4 signalling pathway
MET -> JUN signalling pathway
MET -> STAT5A signalling pathway
MET -> MAX signalling pathway
MPL -> STAT3 signalling pathway
MPL -> STAT5A signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
AREG-EGFR
BTC-EGFR
CCL2-CD4
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
DTR-EGFR
EFNA2-EPHA3
EFNB2-EPHB1
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
EPO-EPOR
EREG-EGFR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF1-FGFR1
FGF1-FGFR2
FGF1-FGFR3
FGF1-GPC1
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FGF7-GPC1
FIGF-KDR
GDNF-RET
GH1-GHR
GH1-IGF1R
GH1-PRLR
GRO1-EGFR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IFNG-HLA-C
IFNG-IFNGR1
IFNG-IFNGR2
IGF1-BST1
IGF1-IGF1R
IGF1-IGF2R
IGF1-LRP5
IL11-IL6R
IL11-IL6ST
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
LEP-LEPR
LEP-LRP2
MDK-ITGB1
MUC4-ERBB2
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NPPA-NPTXR
NRG1-EGFR
NRG1-ERBB2
NTF5-NGFR
NTF5-NTRK1
NTF5-NTRK2
NTF5-NTRK3
NUDT6-FGFR1
PDGFA-PDGFRB
PDGFB-PDGFRB
PGF-KDR
PRL-PRLR
PTH-IL6ST
SDF1-CD4
SDF1-IL6ST
SLIT1-GPC1
SLIT2-GPC1
SPP1-CD44
SPP1-ITGAV
TAC1-TNFRSF11B
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THBS1-ITGB1
THPO-EPOR
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1A
TNF-TNFRSF1B
TNF-TNFRSF6
TNFSF11-TNFRSF11A
TNFSF11-TNFRSF11B
TNFSF5-CD28
TNFSF5-CD80
TNFSF5-TNFRSF5
TNFSF5-TNFRSF6
TNFSF5-TNFRSF7
TNFSF5-TNFRSF8
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
VEGFC-KDR
CB0479 MAPK
GO Biological Process protein amino acid phosphorylation
protein kinase cascade
signal complex formation
cellular physiological process
intracellular signaling cascade
regulation of progression through cell cycle
regulation of cell cycle
cell growth and/or maintenance
oncogenesis
Group Kinases
Sh2
EC Number 2.7.1.112
State proto-oncogene tyrosine-protein kinase SRC
p
State Description Transcript Variant: This variant (1) represents the longer transcript. Both isoforms 1 and 2 encode the same protein.
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both isoforms 1 and 2 encode the same protein.
MGI ID 98397
2444718
Swiss-Prot Accession P12931
OMIM ID 190090
OMIM:190090
Source Curated
BIND
ResNet
 
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