EMD - Calbiochem: VEGF Interactive Pathway

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		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: Caspase-9

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Caspase-9 Antibodies

Product

Application

Species Reactivity

Cat. No.

Anti-Apollon (4775-4829) Rabbit pAb IB, IP human AP1031

Anti-Caspase-9 (1-134) Rabbit pAb IB bovine, chicken, guinea pig, human, monkey, mouse, rat, sheep 218794

Anti-Caspase-9 (Ab-2) Mouse mAb (1-2) IB, NOT FS, NOT IF, NOT IP, NOT PS human AM47

Anti-Caspase-9 (Ab-2) Mouse mAb (1-2) IB, NOT FS, NOT IF, NOT IP, NOT PS human AM47T

Anti-Cleaved Caspase-9 (Asp³¹⁵) Rabbit pAb IB, IP human AP1014

Anti-Cleaved Caspase-9 (Asp³⁵³) Rabbit pAb IB, IC mouse AP1028

Anti-Cleaved Caspase-9 (Asp³⁵³) Rabbit pAb FFS, IB, IC rat AP1015

Anti-Caspase-9, Cleaved (Ab-2) Rabbit pAb IB, IC human PC680

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Caspase-9 Kits

Product

Format

Form

Assay Time

Sample Type

Cat. No.

Caspase-9 Activity Assay Kit, Fluorometric 96-well plate 96 Tests 2-3 h Cell lysate QIA72

Caspase-9 Activity Assay, HTS 96-well plate 96 Tests 3 h Purified protein, cell lysate, or cultured cells HTS04

Active Caspase-9 Assay Kit 96-well plate 480 Tests Cells CBA047

Caspase-9 Assay Kit, Colorimetric Cuvette or 96-well plate 100 Tests 2-3 h Cell lysate 218824

Caspase-9 Detection Kit (FITC-LEHD-FMK) Flow cytometry or fluorescence microscopy 100 Tests 1.5 h Intact cells QIA115

Caspase-9 Detection Kit (Red-LEHD-FMK) Flow cytometry or fluorescence microscopy 100 Tests 1.5 h Intact cells QIA116

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Caspase-9 Enzyme

Product

Cat. No.

Caspase-9, Human, Recombinant, E. coli 218807

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Caspase-9 Inhibitors

Product

Cat. No.

Caspase-9 Inhibitor I 218761

InSolution™ Caspase-9 Inhibitor I 218841

Caspase-9 Inhibitor II, Cell-Permeable 218776

Caspase-9 Inhibitor III 218728

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Caspase-9 Substrates

Product

Cat. No.

Caspase-9 Substrate I, Fluorogenic 218765

Caspase-9 Substrate II, Colorimetric 218805

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Additional Information

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Protein : CASP9

SwissProt Accessions | Entrez Gene links


Connectivity	639
Notes	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants which encode different isoforms.
Hugo ID	1511
Name	CASP9
Description	caspase 9, apoptosis-related cysteine protease
URN	urn:agi-llid:842


GO Cellular Component	cytoplasm
	intracellular


Cell Localization	Cytoplasm


GO Biological Process	apoptosis
	induction of apoptosis
	proteolysis and peptidolysis
	response to hypoxia
	regulation of apoptosis
	apoptotic program
	caspase activation via cytochrome c


EC Number	3.4.22.-


State	caspase 9 isoform alpha preproprotein
	caspase 9 isoform beta preproprotein


State Description	Transcript Variant: This variant (alpha) includes an internal coding region absent in variant beta, and encodes the full-length isoform (alpha).
	Transcript Variant: This variant (beta) lacks an internal coding region present in variant alpha. It uses the same reading frame, however, encodes an isoform (beta) that is missing an internal 150 aa segment as compared to the full-length isoform alpha...


MGI ID	1277950


Swiss-Prot� Accession	P55211


OMIM ID	OMIM:602234


Alias	Casp9
	Mch6
	Apaf3
	caspase 9
	apoptotic protease Mch-6
	Ice-like apoptotic protease 6
	caspase-9-carboxyl-terminal divergent
	apoptotic protease activating factor 3
	Casp9_v1
	Ice-Lap6
	Casp-9-CTD
	Caspase-9
	APAF-3
	caspase 9, apoptosis-related cysteine protease
	apoptotic protease activating factor III
	apoptotic protease MCH VI
	caspase 9 isoform alpha preproprotein
	caspase 9 isoform beta preproprotein
	Caspase IX
	ICE-like apoptotic protease 6
	ICE-like apoptotic protease VI
	Pro-Casp9
	procaspase-9


Organism	Rattus norvegicus
	Mus musculus
	Human


Entrez Gene links�	58918
	170569
	12371
	100030
	100420
	842


RGD ID	61867


Pathway	AKT signaling
	Inhibition of Apoptosis
	Caspases
	Death receptor signaling
	DR3 and DR4-5 pathways
	Mitochondrial control of Apoptosis
	Apoptosis
	AKT signaling


Unigene ID	Rn.32199
	Mm.88829
	Hs.329502


Group	protein binding