		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: cdc42

�

Antibodies

�

Additional Information

�

Protein : CDC42


Name	CDC42
Description	cell division cycle 42 (GTP binding protein, 25kDa)
Owner	Public
URN	urn:agi-llid:998
Connectivity	203
Notes	The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants.
Hugo ID	1736


Microarray ID	I_3307542
	rc_aa925473_at
	1370825_a_at
	rc_aa925473_g_at
	1415724_a_at
	1449574_a_at
	1460708_s_at
	94105_at
	msa.13929.0_f_at
	msa.15668.0_f_at
	msa.1718.0_f_at
	msa.17183.0_f_at
	msa.20163.0_f_at
	msa.27774.0_f_at
	msa.29335.0_f_at
	u37720_f_at
	A_51_P230977
	A_52_P249443
	214230_at
	226400_at
	39736_at
	207273_at
	210232_at
	208728_s_at
	208727_s_at
	AA031548_at
	L10844_at
	rc_h18237_s_at
	A_32_P46891
	A_32_P115015
	A_32_P905712
	A_23_P200560
	A_14_P135733
	A_14_P105052
	A_14_P125675
	A_23_P300056
	A_24_P42633
	M670
	OR2893A
	C154
	OH1648
	OH6041
	MB181
	A_32_P841582
	I_3307541
	A_32_P728316
	I_3339200
	40192_at
	A_65_P17125
	L0265F02-3
	NM_009861
	A_65_P03253
	L0821G05-3
	A_32_P918263
	rc_AI227887_at
	rc_AI227887_g_at
	1435807_at
	116676_at
	Msa.1718.0_at
	I_3334966
	I_942693
	I_1946184
	I_3302284
	A_32_P746970


GenBank ID	183489
	183490
	46397381
	20151145
	21465836
	24158629
	P21181
	NT_039455
	XM_134050
	XP_134050
	NT_039260
	XP_285799
	NT_039266
	NW_043871
	34872298
	31542367
	31542368
	6531680
	6531681
	24637540
	24637541
	4757952
	U76960
	AAA37410
	AAB40051
	AAC00028
	AAH64792
	AAK14822
	AK003098
	AK051543
	AK075567
	AK081384
	AK144216
	AK145659
	AK150563
	AK151087
	AK151726
	AK153564
	AK154870
	AK159470
	AK166281
	AK167195
	AK167400
	AK167609
	AK168013
	AK168076
	AK168089
	AK168276
	AK168503
	AK168758
	AK168820
	AK169122
	AK169232
	AK169805
	AK181967
	AK183308
	AK208829
	AK211726
	AK213611
	AK218916
	BAB22563
	BAC34669
	BAC35825
	BAE25778
	BAE26572
	BAE30100
	BAE30644
	BAE32098
	BAE32891
	BAE35111
	BAE38678
	BAE39325
	BAE39489
	BAE39663
	BAE40000
	BAE40049
	BAE40062
	BAE40222
	BAE40595
	BAE40647
	BAE40902
	BAE41001
	BAE41379
	BC064792
	L11318
	L78075
	M79301
	NC_000070
	NM_009861
	NP_033991
	NT_039267
	P60766
	U37720
	AAF15538
	AAH60535
	AAN63806
	AF205635
	AF491841
	BC060535
	NC_005104
	NM_171994
	NP_741991
	NW_047726
	AAA52592
	AAH02711
	AY673602
	BC002711
	BC003682
	BC018266
	BC018622
	CAB52602
	CAB57325
	CAB57326
	CAB57327
	CAB57328
	CAD92551
	CAI19851
	M35543
	M57298
	NC_000001
	NM_001791
	NM_044472
	NP_001782
	NP_426359
	NT_004610
	NT_086575
	P50290
	P60953
	AAH03682
	AAH18266
	AAM21109
	AAM21110
	AAT70721
	AF498962
	AF498963
	AL031281
	AL121734
	AL121735
	AL121736
	AL121737
	AAA52494
	51709657
	6753363
	6753364
	1321598
	1321599
	12833542
	12833543
	26342013
	26342014
	26344348
	26344349
	40352858
	40352859
	293320
	293321
	192535
	13177603
	1049308
	1049309
	1857297
	46397379
	L10844
	51459124
	16357470
	16357471
	16357472
	51459520
	4826460
	5731800
	31652314
	50234980
	50234981
	20379097
	20379098
	20379099
	20379100
	6012988
	6012989
	6012990
	6012991
	6012992
	6012993
	6012994
	6012995
	33990903
	12803747
	13277547
	13277548
	17390623
	17390624
	17391364
	182856
	182857


Chromosome position	1p36.1
	5q36
	4 66.75 cM


GO ID	GO:0003925
	GO:0003931
	GO:0003924
	GO:0005525
	GO:0005515
	GO:0007015
	GO:0007264
	GO:0007266
	GO:0000910
	GO:0030175
	GO:0005524
	0007266
	0046847
	0051301
	0000910
	0030010
	0000074
	0000166
	0001558
	0003924
	0005515
	0005525
	0005737
	0007015
	0007163
	0007264
	0015031
	0030175
	0030225


Alias	cell division cycle 42 (GTP binding protein, 25kD)
	CD42_HUMAN
	GTP-binding protein G25K, brain
	similar to CDC42 protein [Rattus norvegicus]
	GTP-binding protein G25K, placental
	CDC42Hs
	Cdc42
	cell division cycle 42
	cell division cycle 42 (GTP binding protein, 25kDa)
	cell division cycle 42 homolog
	GTP-binding protein, 25kD
	G25K GTP-binding protein, placental isoform
	G25P_HUMAN
	GTP-binding G25K, placental
	cell division cycle 42 isoform I
	cell division cycle 42 isoform II
	G25K
	cell division cycle 42 isoform 1
	25 kDa GTP-binding protein
	Cdc42 Rho GTPase
	Rho GTPase Cdc42
	cell division cycle 42 isoform 2
	G25P
	similar to CDC42 protein
	cell division cycle 42 (GTP binding, 25kD)
	cell division cycle 42 homolog (S. cerevisiae)
	CD42


Organism	Mus musculus
	Homo sapiens
	Rattus norvegicus
	Human


MedLine Reference	10699171
	12466851
	12637522
	15249579
	15710388
	10490598
	12610628
	11260256
	7513047


LocusLink ID	212710
	332881
	100285
	12540
	64465
	100196
	998


FunctionalClass	GTP binding
	GTPase
	nucleotide binding
	protein binding


RGD ID	71043


Hugo Symbol	CDC42


Unigene ID	Rn.60067
	Mm.1022
	Hs.467637
	Hs.355832
	Rn.8112
	Hs.146409


Keyword	cytoplasm
	small monomeric GTPase
	Rho small monomeric GTPase
	gtpase
	actin
	plasma membrane
	cytoskeleton
	tight junction
	guanine nucleotide dissociation factor
	GTPase activity
	cytosol
	microfilament
	membrane fraction
	guanine nucleotide exchange factor


GO Cellular Component	cytoplasm
	filopodium


GO Molecular Function	small monomeric GTPase activity
	Rho small monomeric GTPase activity
	GTPase activity
	GTP binding
	protein binding
	GTP binding activity
	ATP binding activity
	protein binding activity
	ATP binding


Cell Localization	Plasma membrane
	Cytoplasm


Pathway	Jnk-mapk
	p38 MAPK
	SAPK-JNK Signaling
	p38 Signaling
	TNF-alpha
	LT-alpha
	VIPR1 -> IRF1 signalling pathway
	BMPR2 -> MADH5 signalling pathway
	CD79B -> POU2AF1 signalling pathway
	SSTR1 -> FOS signalling pathway
	ICAP-1A -> MYC signalling pathway
	CNR2 -> EGR1 signalling pathway
	AGT-LRP2
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	CCL19-CD44
	CCL2-CD4
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	DTR-EGFR
	EFNB1-EPHB2
	EFNB1-FGFR2
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	GRO1-EGFR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NTN1-HLA-C
	NTN1-UNC5H2
	PDGFB-PDGFRB
	SDF1-CD4
	SDF1-IL6ST
	SPP1-CD44
	TAC1-TNFRSF11B
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	THBS1-CD36
	THBS1-ITGB1
	THBS1-VLDLR
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	TNFSF6-TNFRSF6
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	VEGF-KDR
	CB0479 MAPK


GO Biological Process	Rho protein signal transduction
	cell division
	filopodium formation
	actin filament organization
	establishment and/or maintenance of cell polarity
	macrophage differentiation
	protein transport
	regulation of cell growth
	regulation of progression through cell cycle
	small GTPase mediated signal transduction
	cytokinesis
	establishment of cell polarity


Group	Gtp binding proteins


State	cell division cycle 42 isoform 1
	cell division cycle 42 isoform 2
	GDP-bound
	GTP-bound


State Description	Transcript Variant: This variant (1) differs from variant 2 at the 3' region including a small part of the coding region and the entire 3' UTR. This variant encodes isoform 1 which has the same aa length but different C-terminus from isoform 2.
	Transcript Variant: This variant (2) differs from variant 1 at the 3' region including a small part of the coding region and the entire 3' UTR. This variant encodes isoform 2 which has the same aa length but different C-terminus from isoform 1.


MGI ID	106211


Swiss-Prot Accession	P21181
	P25763


OMIM ID	116952
	OMIM:116952


Source	Curated
	BIND
	ResNet