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		Protein Tyrosine Kinase

		VEGF

VEGF Interactive Pathway: p38

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Protein : MAPK14


Name	MAPK14
Description	mitogen-activated protein kinase 14
Owner	Public
URN	urn:agi-llid:1432
Connectivity	294
Notes	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Hugo ID	6876


Microarray ID	1367697_at
	rc_aa924542_s_at
	rc_ai137862_s_at
	rc_ai171630_s_at
	u73142_at
	u73142_g_at
	u91847_s_at
	A_43_P12479
	1416703_at
	1416704_at
	1451927_a_at
	99978_s_at
	u10871_s_at
	A_51_P325343
	A_65_P19663
	L35263
	37733_at
	78240_at
	211561_x_at
	202530_at
	211087_x_at
	210449_x_at
	1671_s_at
	1999_s_at
	L35253_s_at
	L35263_at
	A_23_P214696
	A_23_P426292
	A_14_P139376
	A_14_P138042
	A_14_P129108
	A_14_P111428
	A_24_P283288
	A_24_P397566
	704
	OH7873
	M190
	R519
	OR0693
	NM_031020
	1426104_at
	Msa.8386.0_s_at
	Msa.343.0_at
	Msa.8386.0_at
	A_65_P02959
	L0241G04-3
	NM_011951
	AF195850.1
	I_957350


GenBank ID	AAB51285
	AAC71059
	AAH92193
	AAK15541
	AF346293
	BC092193
	NC_005119
	NM_031020
	NP_112282
	NW_047597
	P70618
	U73142
	U91847
	AAA20888
	AAF06348
	AAF34818
	AAH12235
	AAH85303
	AF128892
	AF195850
	AK089059
	AK133684
	AK151348
	AK153025
	AK177608
	AK185139
	AK210810
	AK219197
	BAA19741
	BAC40726
	BAE21782
	BAE30324
	BAE31659
	BC012235
	BC018227
	BC085303
	CAA46200
	D83073
	NC_000083
	NM_011951
	NP_036081
	NT_039649
	P47811
	U10871
	X65067
	AAA57455
	AAA57456
	AAC50329
	AAF36770
	AAH00092
	AAH31574
	AAP35579
	AB074150
	AF100544
	BAB85654
	BC000092
	BC031574
	BT006933
	CAA80919
	CAG38743
	CR536505
	L35263
	L35264
	NC_000006
	NM_001315
	NM_139012
	NM_139013
	NM_139014
	NP_001306
	NP_620581
	NP_620582
	NP_620583
	NT_007592
	NT_086693
	Q16539
	U19775
	Z25432
	49168496
	603916
	603917
	603918
	603919
	405742
	405743
	2499600
	NT_039548
	NW_043430
	34852317
	13591927
	13591928
	13194757
	13194758
	1621646
	1621647
	1916983
	1916984
	2499601
	51770238
	10092589
	10092590
	6996646
	6996647
	6273386
	6273387
	26354195
	26354196
	15126597
	15126598
	17390519
	55154530
	55154531
	1181606
	1945623
	531124
	531125
	50551
	50552
	1346566
	Z95152
	CAB08439
	CAB08440
	51465675
	4503068
	4503069
	20986511
	20986512
	20986513
	20986514
	20986515
	20986516
	51465701
	1136797
	1136798
	3036773
	3392894
	3392895
	19071868
	19071869
	7109716
	7109717
	12652686
	12652687
	21594895
	21594896
	30582704
	30582705
	49168495


Chromosome position	6p21.3-p21.2
	17 13.5 cM
	20p12


GO ID	0004674
	0004707
	0004708
	0004713
	0005524
	0005634
	0005737
	0006468
	0006928
	0006935
	0006950
	0007166
	0007243
	0008339
	0016740
	0019735
	0004682
	GO:0004707
	GO:0004691
	GO:0004682
	GO:0004713
	GO:0005524
	GO:0004674
	GO:0004672
	GO:0016301
	GO:0016740
	GO:0007243
	GO:0006468
	GO:0001525
	GO:0005623
	GO:0005829
	GO:0004708
	GO:0008339
	GO:0006935
	GO:0006950
	GO:0007166
	GO:0006928
	GO:0019735
	GO:0005737
	GO:0005634
	GO:0006960
	0004691
	0005829
	0000077
	0000922
	0001525
	0004672
	0005623
	0006006
	0016301
	0019395
	0045648
	0045944
	0000166


Alias	P-38
	p38ALPHA
	stress-activated protein kinase 2A
	CSBP/p38 MAP kinase
	CSBP/p38 MAPK
	CSBP/p38 kinase
	MAPK14
	PRKM14
	cytokine suppressive anti-inflammatory drug binding protein I
	MAX-interacting protein II
	p38 kinase
	Crk1
	CSBP1
	CSPB I
	CSBP2
	MAP kinase MXI2
	p38 MAPK
	SAPK2A
	mitogen activated protein kinase 14
	Csaids binding protein
	PRKM15
	cytokine-supressive anti-inflammatory drug binding protein
	p38Hog
	MAX-interactive protein 2
	MAX-interactive protein II
	MAP kinase p38
	p38alpha mitogen-activated protein kinase
	cytokine suppressive anti-inflammatory drug binding protein 1
	Exip
	p38alpha Exip
	CSBP I
	PRKM15s
	MAPK14s
	PRKM14s
	mgc102436
	trna synthetase cofactor p38
	CSAID binding protein
	CSPB1
	cytokine suppressive anti-inflammatory drug binding protein
	MAPK p38
	MAX-interacting protein 2
	Mitogen-activated protein kinase p38
	Mxi2
	p38 MAP kinase
	p38 mitogen activated protein kinase
	p38
	Scl12
	Lil I
	Lil1
	Lipid Level QTL 1
	Lipid Level QTL I
	Serum cholesterol level QTL 12
	Serum cholesterol level QTL XII
	RK
	Hog
	CSBP
	MAP kinase 2
	reactive kinase
	p38MAPK
	p38-alpha
	mitogen-activated protein kinase 14


Organism	Human
	Mus musculus
	Homo sapiens
	Rattus norvegicus


MedLine Reference	11687663
	9779826
	10943842
	10973481
	12466851
	12802337
	12808090
	12937170
	15509711
	10706854
	10838079
	10912793
	7997261


LocusLink ID	81649
	1432
	12975
	26416
	326416


FunctionalClass	cAMP-dependent protein kinase
	protein kinase CK2
	kinase
	protein kinase
	ATP binding
	MAP kinase
	MAP kinase kinase
	MP kinase
	nucleotide binding
	protein serine/threonine kinase
	protein-tyrosine kinase
	transferase


RGD ID	70496
	61407


Hugo Symbol	MAPK14


Unigene ID	Rn.88085
	Mm.311337
	Hs.485233
	Mm.347796
	Hs.79107
	Mm.4437


KEGG pathway	MAPK signaling pathway
	Toll-like receptor signaling pathway


Keyword	map kinase
	ERK activator kinase
	tumor necrosis factor
	SAP kinase
	MAP kinase kinase kinase
	phospholipase C
	map kinases
	nucleus


GO Cellular Component	cell
	spindle pole
	cytoplasm
	nucleus
	cytosol


GO Molecular Function	protein kinase CK2 activity
	protein-tyrosine kinase activity
	ATP binding
	protein serine/threonine kinase activity
	protein kinase activity
	kinase activity
	transferase activity
	MAP kinase kinase activity
	MP kinase activity
	protein tyrosine kinase activity
	ATP binding activity
	MAP kinase activity
	cAMP-dependent protein kinase activity


Cell Localization	Nucleus
	Cytoplasm


Pathway	p38 MAPK
	CREB signaling
	p38 Signaling
	ACVR1B -> MADH7 signalling pathway
	ACVRL1 -> MADH5 signalling pathway
	NCAM1 -> TP53 signalling pathway
	NCAM1 -> CREB1 signalling pathway
	TNFRSF10B -> TP53 signalling pathway
	NGFR -> PAX6 signalling pathway
	NGFR -> CREB1 signalling pathway
	NTRK1 -> CREB1 signalling pathway
	NTRK2 -> CREB1 signalling pathway
	OPRD1 -> CREB1 signalling pathway
	TEK -> TCF3 signalling pathway
	TGFBR1 -> SP1 signalling pathway
	TGFBR1 -> MITF signalling pathway
	TLR2 -> HMG1 signalling pathway
	TLR4 -> CEBPA signalling pathway
	TLR4 -> EGR1 signalling pathway
	TNFRSF1A -> ZFP36 signalling pathway
	ADORA1 -> FOS signalling pathway
	AGER -> CREB1 signalling pathway
	AGTR1 -> TP53 signalling pathway
	AGTR1 -> CREB1 signalling pathway
	AGTR2 -> TP53 signalling pathway
	AGTR2 -> CREB1 signalling pathway
	ICAM1 -> TFAP2A signalling pathway
	ICAM1 -> CREB1 signalling pathway
	TNFRSF6 -> MYC signalling pathway
	TNFRSF6 -> FOS signalling pathway
	TNFRSF6 -> SP1 signalling pathway
	TNFRSF6 -> SRF signalling pathway
	TNFRSF6 -> CDX2 signalling pathway
	TNFRSF6 -> CREB1 signalling pathway
	TNFRSF6 -> DDIT3 signalling pathway
	IFNAR1 -> CDX2 signalling pathway
	IL4R -> GATA3 signalling pathway
	IL6R -> MITF signalling pathway
	IL6ST -> MYOG signalling pathway
	IL7R -> LEF1 signalling pathway
	IL7R -> TCF3 signalling pathway
	KLRG1 -> TP53 signalling pathway
	KLRG1 -> PAX6 signalling pathway
	KDR -> NFATC1 signalling pathway
	KDR -> ATF1 signalling pathway
	KDR -> CREB1 signalling pathway
	KIT -> TP53 signalling pathway
	KIT -> MITF signalling pathway
	LEPR -> TCF3 signalling pathway
	CD2 -> GATA3 signalling pathway
	CD4 -> NFATC2 signalling pathway
	CD4 -> TP53 signalling pathway
	CD4 -> GATA3 signalling pathway
	CD4 -> STAT6 signalling pathway
	TNFRSF7 -> TP53 signalling pathway
	CD28 -> GATA3 signalling pathway
	CD28 -> TCF3 signalling pathway
	CD28 -> CREB1 signalling pathway
	TNFRSF8 -> MYC signalling pathway
	TNFRSF8 -> TP53 signalling pathway
	CD38 -> MYBL1 signalling pathway
	CD38 -> TCF3 signalling pathway
	TNFRSF5 -> MYC signalling pathway
	TNFRSF5 -> TP53 signalling pathway
	TNFRSF5 -> TCF3 signalling pathway
	EPHA3 -> TP53 signalling pathway
	EPHA3 -> TCF3 signalling pathway
	EPHA4 -> STAT3 signalling pathway
	EPHA4 -> CTNNB1 signalling pathway
	ERBB2 -> TP53 signalling pathway
	ERBB2 -> SP1 signalling pathway
	ERBB2 -> MADH7 signalling pathway
	F2R -> CREB1 signalling pathway
	FCGR2B -> GATA4 signalling pathway
	FGFR1 -> CREB1 signalling pathway
	FGFR2 -> FOS signalling pathway
	FLT1 -> NFATC1 signalling pathway
	FLT1 -> CREB1 signalling pathway
	FSHR -> GATA4 signalling pathway
	SPN -> TP53 signalling pathway
	SPN -> TCF3 signalling pathway
	SSTR3 -> TP53 signalling pathway
	TACR1 -> CREB1 signalling pathway
	GPR9 -> CDX2 signalling pathway
	TBXA2R -> CREB1 signalling pathway
	CCR5 -> TP53 signalling pathway
	TAS2R13 -> ATF4 signalling pathway
	PTPRA -> TEAD1 signalling pathway
	PTPRC -> NFATC2 signalling pathway
	DRD1 -> CREB1 signalling pathway
	EDNRA -> CREB1 signalling pathway
	EDNRB -> CREB1 signalling pathway
	EGFR -> TP53 signalling pathway
	EPHA2 -> TP53 signalling pathway
	MC1R -> MADH6 signalling pathway
	MC1R -> MADH7 signalling pathway
	MC1R -> MITF signalling pathway
	MET -> TP53 signalling pathway
	MET -> MAX signalling pathway
	AGT-LRP2
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	BMP2-ACVR1
	BMP2-ACVR2
	BMP2-BMPR1A
	BMP2-BMPR1B
	BMP2-BMPR2
	BMP4-ACVR1
	BMP4-BMPR1A
	BMP4-BMPR1B
	BMP4-BMPR2
	BMP7-ACVR1
	BMP7-ACVR2
	BMP7-ACVR2B
	BMP7-BMPR1A
	BMP7-BMPR1B
	BMP7-BMPR2
	BTC-EGFR
	CCL2-CD4
	CCL22-VCAM1
	CCL4-CD4
	CCL4-TNFRSF8
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF2-CSF2RA
	CSF3-CSF3R
	CSF3-IL6R
	DTR-CD44
	DTR-EGFR
	DTR-ERBB4
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	EPO-EPOR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GH1-GHR
	GH1-IGF1R
	GH1-PRLR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNA1-CR2
	IFNA1-IFNAR1
	IFNA1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	IL10-IL10RA
	IL10-TNFRSF7
	IL13-IL13RA1
	IL13-IL13RA2
	IL13-IL2RG
	IL13-IL4R
	IL15-IL15RA
	IL15-IL2RB
	IL15-IL2RG
	IL16-CD4
	IL17-IL17R
	IL1A-IL1R1
	IL1A-IL1RAP
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL2-IL15RA
	IL2-IL2RA
	IL2-IL2RB
	IL2-IL2RG
	IL2-IL4R
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL5-IL5RA
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	IL7-IL2RG
	IL7-IL7R
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	KITLG-KIT
	LEP-LEPR
	LEP-LRP2
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NPPA-NPTXR
	NRG1-CD44
	NRG1-EGFR
	NRG1-ERBB2
	NRG1-ERBB3
	NRG1-ERBB4
	NRG2-ERBB3
	NTF3-CNTFR
	NTF3-NGFR
	NTF3-NTRK1
	NTF3-NTRK2
	NTF3-NTRK3
	NTN1-HLA-C
	OSM-CD22
	OSM-IL6ST
	OSM-LIFR
	PGF-FLT1
	PGF-KDR
	PTH-IL6ST
	SDF1-CD4
	SDF1-IL6ST
	TAC1-TNFRSF11B
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	THBS1-CD36
	THBS1-ITGB1
	THBS1-VLDLR
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	TNFSF10-TNFRSF10A
	TNFSF10-TNFRSF10B
	TNFSF10-TNFRSF1A
	TNFSF10-TNFRSF6
	TNFSF11-TNFRSF11A
	TNFSF11-TNFRSF11B
	TNFSF13B-TNFRSF13B
	TNFSF13B-TNFRSF13C
	TNFSF13B-TNFRSF17
	TNFSF5-CD28
	TNFSF5-CD80
	TNFSF5-TNFRSF5
	TNFSF5-TNFRSF6
	TNFSF5-TNFRSF7
	TNFSF5-TNFRSF8
	TNFSF6-TNFRSF6
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	VEGF-KDR
	CB0479 MAPK


GO Biological Process	antimicrobial humoral response (sensu Invertebrata)
	DNA damage checkpoint
	angiogenesis
	fatty acid oxidation
	glucose metabolism
	positive regulation of erythrocyte differentiation
	positive regulation of transcription from RNA polymerase II promoter
	antimicrobial humoral response (sensu Vertebrata)
	cell motility
	cell surface receptor linked signal transduction
	chemotaxis
	protein amino acid phosphorylation
	protein kinase cascade
	response to stress


Group	Kinases


EC Number	2.7.1.37
	2.7.1.-


State	isoform 1
	isoform 2
	isoform 3
	isoform 4
	p


State Description	Transcript Variant: This variant (1) encodes the longest isoform (1).
	Transcript Variant: This variant (2) contains a different segment within the coding region when compared to variant 1. The translation frame remains the same, and the resulting isoform 2 has an internal segment different from that of isoform 1.
	Transcript Variant: This variant (3) contains a different internal segment within the coding region, and a different 3' coding region as well as a different 3' UTR, when compared to variant 1. It thus encodes an isoform that has a different internal se...
	Transcript Variant: This variant (4) contains a different internal segment when compared to variant 1. It thus encodes an isoform that has a different and shorter internal segment, as compared to isoform 1.


MGI ID	1346865


Swiss-Prot Accession	Q16539


OMIM ID	600289
	61407
	OMIM:600289


Source	BIND
	ResNet
	Curated