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Insulin Pathway: Akt
 
Akt Antibodies and Blocking Peptides
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Anti-Akt, PH Domain Mouse mAb (SKB1) FC, IB, IP human, mouse, rat ST1088
Anti-Akt1 (Ab-1) (135-145) Rabbit pAb IC, NOT IB, NOT PS human, mouse PC510
Anti-Akt1 (88-100) Rabbit pAb ELISA, IB, IP human, mouse, rat, Xenopus 530311
PhosphoDetect™ Anti-Akt1 (pSer473) Mouse mAb (11E6) ELISA, IB human, mouse 124003
PhosphoDetect™ Anti-Akt1 (pThr308) Rabbit pAb IB human, mouse 124001
Anti-Akt2 Rabbit pAb ELISA, IB human, mouse, rat 124002
 
Akt Assay Kits
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Akt Activity Immunoassay Kit 124007
K-LISA™ Akt Activity Kit CBA019
PhosphoDetect™ Akt (pSer473) ELISA Kit CBA005
PhosphoDetect™ Akt (pThr308) ELISA Kit CBA004
 
Akt Inhibitors
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Akt Inhibitor 124005
Akt Inhibitor II 124008
Akt Inhibitor III 124009
Akt Inhibitor IV 124011
InSolution™ Akt Inhibitor IV 124015
Akt Inhibitor V, Triciribine 124012
Akt Inhibitor VI, Akt-in 124013
Akt Inhibitor VII, TAT-Akt-in 124014
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124017
Akt Inhibitor IX, API-59CJ-OMe 124019
Akt Inhibitor X 124020
Akt Inhibitor XI 124028
(-)-Deguelin, Mundulea sericea 252740
PDK1/Akt/Flt Dual Pathway Inhibitor 521275
 
Akt Substrates/Enzymes
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Akt1, His•Tag®, Activated, Human, Recombinant, S. frugiperda 124006
Akt2, GST-Fusion Protein, Human, Recombinant, S. frugiperda 124021
Akt3, GST-Fusion Protein, Human, Recombinant, S. frugiperda 124022
AKTide-2T 123900
PKBa Substrate 539622
 
Additional Information
 
 
 
 

Protein : AKT1

Name AKT1
Description thymoma viral proto-oncogene 1
Owner Public
URN urn:agi-llid:207
Connectivity 1134
Notes The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Hugo ID 391
Microarray ID 1368862_at
A_43_P12733
A_51_P237553
A_65_P03244
M63167
67939_at
207163_s_at
1564_at
M63167_at
81268_at
rc_aa011575_f_at
rc_aa041305_f_at
rc_aa044077_f_at
rc_aa056416_f_at
rc_aa063612_f_at
rc_t03388_f_at
A_23_P14358
A_14_P108902
A_14_P105663
A_14_P138231
A_23_P2960
M640
C296
OH8088
R083
OR0248
1375178_at
D30040_at
NM_033230
100970_at
1416657_at
1425711_a_at
x65687_s_at
Msa.237.0_at
M94335.1
A_65_P20672
H3020C06-3
NM_009652
I_959380
GenBank ID 200642
AAA18254
AAH66018
AAN04036
AF534134
AK040758
AK154936
AK196375
AK211494
AK214116
AK216454
BAC30695
BAE32937
BC066018
CAA46620
M94335
NC_000078
NM_009652
NP_033782
NT_039551
P31750
X65687
A62733
A63232
AAA36539
AAH00479
AAH01737
AAH84538
AAL55732
AF283830
AK094287
AK122894
AK127193
AK131465
BAD18610
BC000479
BC001737
BC063408
BC084538
BX647722
BX648205
CAA03677
CAA03712
CAA43372
M63167
NC_000014
NM_001014431
NM_001014432
NM_005163
NP_001014431
NP_001014432
NP_005154
NT_026437
NT_086807
P31749
X61037
AA588967
AAB29006
AAH21313
AAH48179
AK011876
AK028483
AK030736
AK038919
AK079866
AK149844
AK164578
BAB27894
BAC27105
BAC30169
BAE29117
BC021313
BC048179
NC_000086
NM_145956
NP_666068
NT_039706
NT_039753
P46737
S68022
BAA06279
D30040
NC_005105
NM_033230
NP_150233
NW_047762
P47196
287806
287807
400144
51493278
4885060
4885061
51472322
3716605
3716606
3717080
3717081
18027297
18027298
34528338
33875493
12653417
12804626
12804627
54038760
54038761
34367364
190827
190828
35480
35481
400143
200641
34935858
15100163
15100164
485402
485403
1346401
NT_039553
51829386
6753033
6753034
22653383
22653384
26333954
26333955
41946109
41946110
Chromosome position X A7.3
6q32
14q32.32
12 57.0 cM
GO ID GO:0005737
GO:0004702
GO:0009408
GO:0006809
GO:0007186
GO:0005634
GO:0007048
0000074
0004672
0004674
0005515
0005737
0005819
0006915
0007281
0008637
0016301
0016567
0030027
0030163
0042640
0043066
0050875
0000166
0004702
0004713
0005524
0005634
0006468
0006809
0006916
0007165
0007186
0009408
0016740
0000151
0010165
0030234
0030307
GO:0005524
GO:0004674
GO:0004672
GO:0016740
GO:0006916
GO:0006468
GO:0007165
GO:0030307
GO:0004713
GO:0005515
GO:0016301
GO:0008637
GO:0007281
GO:0008151
GO:0006915
GO:0000074
GO:0016567
GO:0030163
Alias RAC
Ms6-1
minisatellite I
minisatellite-1
minisatellite-1 detected by probe 33.6
Ms6 I
minisatellite-1 detected by probe 33
murine thymoma viral (v-akt) oncogene homolog 1
PKBalpha
KRAC
serine/threonine protein kinase
KRAC_HUMAN
Akt1/PKB protein kinase
AKT1 protein
PKB-ALPHA
Protein kinase B
amelogenesis imperfecta 3, hypomaturation or hypoplastic type
AIH3
similar to thymoma viral proto-oncogene 1; thymoma viral proto-oncogene
6.1a protein
Akt/PKB
Akt
PKB
RAC protein kinase alpha RAC-PK alpha
Murine thymoma viral (v-akt) oncogene homolog-1
RAC-ALPHA
Akt/PKBs
PKB/Akts
C-AKT
PKB alpha
PRKBA
RAC-alpha serine/threonine kinase
RAC-PK-alpha
serine/threonine protein kinase B
thymoma viral proto-oncogene
thymoma viral proto-oncogene 1
v-akt murine thymoma viral oncogene homolog 1
MGC29148
thymoma viral proto-oncogene I
v-akt murine thymoma viral oncogene homolog I
C6.1A
PKB/Akt
AKTI
Akt1
Murine thymoma viral (v-akt) oncogene homolog I
Akt I
Protein kinase B
Organism Mus musculus
Rattus norvegicus
Homo sapiens
Human
MedLine Reference 12124386
12140361
12145204
12466851
12869584
12944902
15192701
15509711
15713628
10376602
10570282
10748004
10958679
12084817
12194869
LocusLink ID 111651
201
268604
11651
207
210766
24185
50586
FunctionalClass protein binding
protein kinase
protein serine/threonine kinase
ATP binding
nucleotide binding
protein-tyrosine kinase
receptor signaling protein serine/threonine kinase
transferase
enzyme regulator
kinase
RGD ID 2081
Hugo Symbol AKT1
Unigene ID Rn.11422
Mm.6645
Hs.525622
Hs.368861
Hs.71816
KEGG pathway Apoptosis
Focal adhesion
Jak-STAT signaling pathway
MAPK signaling pathway
Tight junction
Toll-like receptor signaling pathway
Keyword protein serine/threonine kinase
plasma membrane
map kinase
docking protein
cyclin
5.4.2.-
ph domain
nucleus
map kinases
protein serine/threonine kinase activity
gtpase
cytosol
cytoplasm
small monomeric GTPase
MEK
protein tyrosine kinase
GO Cellular Component cytoplasm
lamellipodium
spindle
ubiquitin ligase complex
nucleus
GO Molecular Function ATP binding
protein serine/threonine kinase activity
protein kinase activity
transferase activity
protein-tyrosine kinase activity
protein binding
kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding activity
protein tyrosine kinase activity
Cell Localization Cytoplasm
Nucleus
Pathway p40 MAPK
CREB signaling
AKT signaling
Antiapoptotic Pathways From IGF-1R
ACH-R in apoptosis
Jak-Stat Pathway from IL6 Receptor
PTEN signaling
Insulin Receptor Signaling
Apoptosis
Mitochondrial control of Apoptosis
Inhibition of Apoptosis
ACVRL1 -> MADH5 signalling pathway
NCAM1 -> CREB1 signalling pathway
TNFRSF11A -> JUN signalling pathway
NGFR -> FOS signalling pathway
NGFR -> PAX6 signalling pathway
NGFR -> CEBPB signalling pathway
NGFR -> CREB1 signalling pathway
NOTCH1 -> MYOD1 signalling pathway
NOTCH1 -> NFKB2 signalling pathway
NOTCH1 -> FOS signalling pathway
NOTCH1 -> HEY2 signalling pathway
NOTCH1 -> MEF2C signalling pathway
NOTCH4 -> HEY2 signalling pathway
NPHS1 -> JUN signalling pathway
NTRK1 -> MYC signalling pathway
NTRK1 -> MYCN signalling pathway
NTRK1 -> TP53 signalling pathway
NTRK1 -> FOXO1A signalling pathway
NTRK1 -> FOXO3A signalling pathway
NTRK1 -> CREB1 signalling pathway
NTRK2 -> JUN signalling pathway
NTRK2 -> CREB1 signalling pathway
NTRK3 -> MYC signalling pathway
NTRK3 -> JUN signalling pathway
NTRK3 -> POU4F1 signalling pathway
OPRM1 -> FOS signalling pathway
TEK -> STAT3 signalling pathway
TEK -> TCF3 signalling pathway
TEK -> CEBPB signalling pathway
TGFBR1 -> SP1 signalling pathway
TGFBR1 -> MADH4 signalling pathway
TLR2 -> HMG1 signalling pathway
TLR4 -> HSPCA signalling pathway
TLR4 -> CEBPA signalling pathway
TLR4 -> EGR1 signalling pathway
TNFRSF1A -> REL signalling pathway
TNFRSF1A -> RELA signalling pathway
TRIO -> MYC signalling pathway
ADORA1 -> FOS signalling pathway
ADRB1 -> MYC signalling pathway
AGER -> MYOG signalling pathway
AGER -> HMG1 signalling pathway
AGTR2 -> TP53 signalling pathway
AGTR2 -> JUN signalling pathway
AGTR2 -> PAX2 signalling pathway
AGTR2 -> CREB1 signalling pathway
VCAM1 -> RELA signalling pathway
VIPR1 -> CREB1 signalling pathway
ICAM1 -> NFKB1 signalling pathway
ICAM1 -> TFAP2A signalling pathway
ICAM1 -> CREB1 signalling pathway
ICAM2 -> FOXO1A signalling pathway
TNFRSF6 -> MYC signalling pathway
TNFRSF6 -> HIF1A signalling pathway
TNFRSF6 -> HSPCA signalling pathway
TNFRSF6 -> BCL6 signalling pathway
TNFRSF6 -> BRCA1 signalling pathway
TNFRSF6 -> FOXO3A signalling pathway
TNFRSF6 -> FOS signalling pathway
TNFRSF6 -> SP1 signalling pathway
TNFRSF6 -> SREBF1 signalling pathway
TNFRSF6 -> SRF signalling pathway
TNFRSF6 -> CREB1 signalling pathway
TNFRSF6 -> ATF2 signalling pathway
TNFRSF6 -> DDIT3 signalling pathway
TNFRSF6 -> RELA signalling pathway
IGF1R -> MYC signalling pathway
IGF1R -> MYCN signalling pathway
IGF1R -> FOXO1A signalling pathway
IL1R1 -> FOS signalling pathway
IL4R -> MYC signalling pathway
IL4R -> TP73 signalling pathway
IL4R -> GATA3 signalling pathway
IL6R -> JUNB signalling pathway
IL6R -> MITF signalling pathway
IL6ST -> MYC signalling pathway
IL6ST -> MYOG signalling pathway
IL6ST -> JUN signalling pathway
IL6ST -> CEBPA signalling pathway
IL6ST -> CEBPB signalling pathway
IL7R -> TCF1 signalling pathway
IL7R -> TCF3 signalling pathway
KLRG1 -> MYC signalling pathway
KLRG1 -> TP53 signalling pathway
KLRG1 -> IPF1 signalling pathway
KLRG1 -> FOS signalling pathway
KLRG1 -> PAX6 signalling pathway
ITGAM -> RELA signalling pathway
ITGB1 -> MYC signalling pathway
ITGB1 -> CTNNB1 signalling pathway
ITGB2 -> CEBPB signalling pathway
BMPR2 -> MADH5 signalling pathway
KDR -> NFATC1 signalling pathway
KDR -> CREB1 signalling pathway
KIT -> MYC signalling pathway
KIT -> TP53 signalling pathway
KIT -> FOS signalling pathway
KIT -> TAL1 signalling pathway
CCKBR -> CTNNB1 signalling pathway
LEPR -> TCF1 signalling pathway
CD2 -> MYC signalling pathway
CD2 -> IRF1 signalling pathway
CD2 -> GATA3 signalling pathway
CD4 -> NFATC2 signalling pathway
CD4 -> STAT1 signalling pathway
CD4 -> CEBPA signalling pathway
CD4 -> MADH3 signalling pathway
CD14 -> IRF3 signalling pathway
CD19 -> JUND signalling pathway
CD19 -> FOS signalling pathway
CD28 -> MYC signalling pathway
CD28 -> CREB1 signalling pathway
CD28 -> ATF2 signalling pathway
CD28 -> REL signalling pathway
CD28 -> RELA signalling pathway
CD38 -> MYBL1 signalling pathway
CD38 -> TCF3 signalling pathway
TNFRSF5 -> TP53 signalling pathway
TNFRSF5 -> FOXO1A signalling pathway
TNFRSF5 -> FOS signalling pathway
TNFRSF5 -> TCF3 signalling pathway
TNFRSF5 -> CREB1 signalling pathway
CD79A -> MYC signalling pathway
KLRA1 -> TCF1 signalling pathway
EPHA3 -> TP53 signalling pathway
EPHA3 -> CTNNB1 signalling pathway
EPHA4 -> JUN signalling pathway
EPHA4 -> CTNNB1 signalling pathway
EPOR -> CEBPA signalling pathway
ERBB2 -> TP53 signalling pathway
ERBB2 -> FOXO3A signalling pathway
ERBB2 -> CTNNB1 signalling pathway
ERBB3 -> MYOG signalling pathway
F2R -> SP1 signalling pathway
F2R -> SRF signalling pathway
F2R -> CEBPB signalling pathway
F2R -> CREB1 signalling pathway
F2R -> CTNNB1 signalling pathway
EDAR -> CTNNB1 signalling pathway
FCGR2B -> YY1 signalling pathway
FCGR3A -> MYC signalling pathway
FCGR3A -> FOS signalling pathway
FGFR1 -> JUN signalling pathway
FGFR1 -> CREB1 signalling pathway
FGFR3 -> SOX9 signalling pathway
FGFR2 -> SOX9 signalling pathway
FLT1 -> NFATC1 signalling pathway
FLT1 -> HIF1A signalling pathway
FLT1 -> FOS signalling pathway
FLT1 -> CREB1 signalling pathway
FLT3 -> FOXO3A signalling pathway
FLT3 -> CEBPA signalling pathway
CD244 -> EGR3 signalling pathway
FSHR -> FOS signalling pathway
FSHR -> GATA4 signalling pathway
SPN -> MYC signalling pathway
SPN -> TCF3 signalling pathway
GCGR -> TP53 signalling pathway
GHR -> MYC signalling pathway
GHR -> FOS signalling pathway
GHR -> SPI1 signalling pathway
GHR -> EGR1 signalling pathway
SSTR1 -> FOS signalling pathway
SSTR2 -> TP53 signalling pathway
SSTR2 -> JUN signalling pathway
SSTR2 -> ATF2 signalling pathway
GPR9 -> RELA signalling pathway
GRIA3 -> FOS signalling pathway
PDGFRB -> MYC signalling pathway
PECAM1 -> RBL2 signalling pathway
EDG5 -> JUN signalling pathway
CHRNA7 -> CREB1 signalling pathway
CCR4 -> CNOT4 signalling pathway
CNR1 -> EGR1 signalling pathway
CNR2 -> EGR1 signalling pathway
PLAUR -> FOS signalling pathway
PLAUR -> SP1 signalling pathway
CSF1R -> MYC signalling pathway
CSF3R -> MYC signalling pathway
CSF3R -> SPI1 signalling pathway
TAS2R13 -> ATF4 signalling pathway
PTGDR -> EGR1 signalling pathway
PTPRC -> NFATC2 signalling pathway
PTPRJ -> FOS signalling pathway
DRD2 -> JUN signalling pathway
DRD3 -> FOS signalling pathway
RET -> JUN signalling pathway
EDNRB -> CREB1 signalling pathway
EGFR -> TP53 signalling pathway
EGFR -> CREB1 signalling pathway
MC1R -> MADH6 signalling pathway
MET -> TP53 signalling pathway
MET -> JUN signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
AREG-EGFR
BDNF-NCAM1
BDNF-NGFR
BDNF-NTRK1
BDNF-NTRK2
BDNF-NTRK3
BMP2-ACVR1
BMP2-ACVR2
BMP2-BMPR1A
BMP2-BMPR1B
BMP2-BMPR2
BTC-EGFR
CCL2-CD4
CLC-CNTFR
CLC-IL6ST
CNTF-CNTFR
CNTF-IL6ST
CNTF-LIFR
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF2-CSF2RA
CSF3-CSF3R
CSF3-IL6R
CTF1-IL6ST
DTR-CD44
DTR-EGFR
DTR-ERBB4
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
EPO-EPOR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF1-FGFR1
FGF1-FGFR2
FGF1-FGFR3
FGF1-GPC1
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FGF7-FGFR2
FGF7-GPC1
GDNF-RET
GH1-GHR
GH1-IGF1R
GH1-PRLR
GRO1-EGFR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IFNB1-IFNAR1
IFNB1-IFNAR2
IFNG-HLA-C
IFNG-IFNGR1
IFNG-IFNGR2
IGF1-BST1
IGF1-IGF1R
IGF1-IGF2R
IGF1-LRP5
IGF2-IGF1R
IGF2-IGF2R
IL10-IL10RA
IL10-TNFRSF7
IL13-IL13RA1
IL13-IL13RA2
IL13-IL2RG
IL13-IL4R
IL15-IL15RA
IL15-IL2RB
IL15-IL2RG
IL16-CD4
IL1B-HLA-DRB1
IL1B-IL1R1
IL1B-IL1RAP
IL1B-IL6R
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL4-FCER2
IL4-IL2RG
IL4-IL4R
IL5-IL5RA
IL5-IL6ST
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL7-IL2RG
IL7-IL7R
IL9-IL9R
INHBA-ACVR1B
INHBA-ACVR2
INHBA-ACVR2B
INHBA-ACVRL1
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
LEP-LEPR
LEP-LRP2
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
MDK-ITGB1
MDK-LRP2
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NPPA-NPTXR
NRG1-CD44
NRG1-EGFR
NRG1-ERBB2
NRG1-ERBB3
NRG1-ERBB4
NTF3-CNTFR
NTF3-NGFR
NTF3-NTRK1
NTF3-NTRK2
NTF3-NTRK3
NTF5-NGFR
NTF5-NTRK1
NTF5-NTRK2
NTF5-NTRK3
NUDT6-FGFR1
OSM-CD22
OSM-IL6ST
OSM-LIFR
PDGFA-PDGFRB
PDGFB-PDGFRB
PGF-FLT1
PGF-KDR
PRL-PRLR
PTH-IL6ST
SDF1-CD4
SDF1-IL6ST
SPP1-CD44
SPP1-ITGAV
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THBS1-CD36
THBS1-ITGB1
THBS1-VLDLR
THPO-EPOR
THPO-MPL
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1A
TNF-TNFRSF1B
TNF-TNFRSF6
TNFSF10-TNFRSF10A
TNFSF10-TNFRSF10B
TNFSF10-TNFRSF1A
TNFSF10-TNFRSF6
TNFSF11-TNFRSF11A
TNFSF11-TNFRSF11B
TNFSF5-CD28
TNFSF5-CD80
TNFSF5-TNFRSF5
TNFSF5-TNFRSF6
TNFSF5-TNFRSF7
TNFSF5-TNFRSF8
TNFSF6-TNFRSF6
TNFSF7-CD28
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
VEGFC-FLT1
VEGFC-FLT4
VEGFC-KDR
WNT1-LRP5
WNT1-LRP6
WNT1-ROR2
CB0480 Insulin
mTOR
simple mTOR
GO Biological Process anagen
apoptosis
apoptotic mitochondrial changes
cellular physiological process
germ cell development
negative regulation of apoptosis
protein catabolism
protein ubiquitination
regulation of progression through cell cycle
positive regulation of cell growth
response to X-ray
G-protein coupled receptor protein signaling pathway
anti-apoptosis
nitric oxide biosynthesis
protein amino acid phosphorylation
response to heat
signal transduction
regulation of cell cycle
cell growth and/or maintenance
germ-cell development
oncogenesis
Group Kinases
Ph
EC Number 2.7.1.-
2.7.1.37
State p
MGI ID 87986
97157
Swiss-Prot Accession P31749
OMIM ID 164730
181500
OMIM:164730
OMIM:181500
OMIM:301201
Source Curated
BIND
ResNet
 
 
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