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Technical Information
Calbiochem Information
Interactive Pathways
Protein Tyrosine Kinase
Insulin
Insulin Pathway: APS
 

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For additional information on this protein, please refer to the general information provided below.

 
 
 

Protein : APS

Name APS
Description adaptor protein with pleckstrin homology and src homology 2 domains
Owner Public
URN urn:agi-llid:10603
Connectivity 31
Notes The APS protein, expressed in B lymphocytes, contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.

Microarray ID 37136_at
205367_at
A_23_P59507
A_14_P106395
CA003
OH8204
OR2618
RA1161
af095576_at
A_42_P729496
A_51_P404023
1368605_at

GenBank ID NT_079691
34873375
16758939
16758940
34871762
3766233
3766234
51493052
10280625
10280626
37539429
51466710
2447035
2447036
34098358
51711399
40254555
40254556
3641292
3641293
7188825
7188826
12856929
34785379
34785380
34098366
AB000520
BAA22514
NC_000007
NM_020979
NP_066189
NT_007933
NT_079596
NT_086725
O14492
AAC64408
AF095576
NC_005111
NM_053669
NP_446121
NW_047370
Q9Z200
AAC36336
AAF37891
AAH57334
AF086810
AF234838
AK017604
AK140319
AK140325
BAE24331
BAE24336
BC049777
BC057334
NC_000071
NM_018825
NP_061295
NT_080526
Q9JID9

Chromosome position 5 G1
12q12
7q22

GO ID 0001922
0005068
0005515
0005884
0008286
0016020
0019221
0019222
0030036
0005070
0005737
0005886
0007242
0008269
0019735
0007399
0046578
0042593
0046325
0050776
0050851

Alias Aps
homology 2 domains
insulin receptor substrate 5
adaptor containing Pleckstrin homology (PH) Src homology-2 (SH2) domains
APS adaptor containing Pleckstrin homology PH Src homology-2 (SH2) domains
APS adaptor molecule containing PH and SH2 domains
adaptor molecule containing PH and SH2 domains
adaptor protein with pleckstrin homology and src
Irs5
insulin receptor substrate V
adaptor protein with pleckstrin homology and src homology 2 domains

Organism Rattus norvegicus
Mus musculus
Homo sapiens

MedLine Reference 10374881
9233773
9989826
9856458
10196204
10872802
12466851
14578283
14993264

LocusLink ID 10603
54699
114203
23921

FunctionalClass protein binding
transmembrane receptor protein tyrosine kinase adaptor protein
JAK pathway signal transduction adaptor
SH3/SH2 adaptor

RGD ID 69284

Unigene ID Rn.30041
Hs.489448
Mm.277333

GO Cellular Component actin filament
membrane
cytoplasm
plasma membrane

Cell Localization Plasma membrane
Cytoplasm

Pathway GH1-IGF1R
IGF1-BST1
IGF1-IGF2R
IGF1-LRP5
IL4-FCER2
INS-HLA-DRB1
INS-TFRC
CB0480 Insulin

GO Biological Process B-1 B-cell homeostasis
neurogenesis
regulation of Ras protein signal transduction
B-1 B cell homeostasis
actin cytoskeleton organization and biogenesis
antigen receptor-mediated signaling pathway
cytokine and chemokine mediated signaling pathway
glucose homeostasis
insulin receptor signaling pathway
negative regulation of glucose import
regulation of immune response
regulation of metabolism
antimicrobial humoral response (sensu Vertebrata)
intracellular signaling cascade

Group Ph
Sh2

MGI ID 1345171

OMIM ID 605300

Source Curated