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Technical Information
Calbiochem Information
Interactive Pathways
Protein Tyrosine Kinase
Insulin
Insulin Pathway: GRB2
 

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For additional information on this protein, please refer to the general information provided below.

 
 
 

Protein : Grb2

Name Grb2
Description growth factor receptor bound protein 2
Owner Public
URN urn:agi-llid:2885
Connectivity 326
Notes The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Hugo ID 4566

Microarray ID 1368385_a_at
1368386_at
rc_aa801130_at
A_43_P15304
A_51_P198411
A_51_P198410
L29511
215075_s_at
33855_at
223049_at
228572_at
1565_s_at
AA059415_at
M96995_s_at
A_23_P418537
A_23_P77847
A_23_P89246
A_24_P407717
A_24_P39654
A_14_P128518
A_14_P128049
A_14_P109665
377
OH7726
R114
OR0277
OR3583
MA310
D49847_at
rc_AI170776_s_at
1370617_at
NM_030846
101034_at
1418508_a_at
1449111_a_at
u07617_s_at
Msa.203.0_at
NM_008163
I_958081
I_958080
NM_002086.1

GenBank ID BI459414
BQ073225
BQ962129
CAA44664
CAG29359
CAG46740
CR450363
CR541942
L29511
M96995
NC_000017
NM_002086
NM_203506
NP_002077
NP_987102
NT_010641
NT_086886
P62993
AAB40022
AAH52377
AAH85254
AK077750
AK079087
AK148148
AK153557
AK155800
AK166142
AK170845
AK172002
AK177056
AK180406
AK181485
AK192421
AK196759
AK211391
BAA12862
BAE28376
BAE32093
BAE33439
BAE38595
BAE42068
BC052377
BC085254
D85748
NC_000077
NM_008163
NP_032189
NT_039521
Q60631
U07617
6680083
26097471
26098268
30851532
30851533
55154543
55154544
1375040
1375041
464004
464005
2498425
51474120
45359857
4504111
45359858
45359859
51474508
3850300
3850302
2165703
33337967
33337968
12005510
12005511
11036972
11036973
20379025
20379026
10436843
10436844
21749282
33875666
12653693
14714383
33877979
21707087
25123147
27695085
15250070
19902271
22377607
47496672
47496673
49456838
49456839
460667
498178
181975
181976
28875
28876
51702266
284139
6679879
AAH09417
AAH19082
P29354
NW_042679
XM_192723
NT_039264
XM_122349
XP_122349
NW_043365
XM_218527
XP_218527
XP_192723
BX883048
CAE84044
46237653
46237669
57012406
57012405
NP_001008826
51766637
34328126
34875497
13540653
13540654
914956
914957
914960
914961
914958
914959
55762
55763
X62852
AAH91144
BAA08645
BAA08646
BAA08647
BC091144
CAA44665
D49846
D49847
D49848
NC_005109
NM_030846
NP_110473
NW_047343
P62994
X62853
AA452034
AAA58448
AAC37549
AAC72075
AAG27442
AAG44485
AAH00631
AAM21073
AAQ13606
AF063618
AF171699
AF246238
AF302079
AF498925
AK024539
AK091010
BAB14923
BC000631
BC009417
BC019082
BC033644
BC039827
BC043007

Chromosome position 11 75.0 cM
17q24-q25
10q32.3

GO ID GO:0005070
GO:0007173
GO:0007265
GO:0007242
GO:0007267
GO:0005515
GO:0004872
GO:0012506
0005070
0005154
0005515
0005829
0007173
0007242
0007265
0007267
0000165
0005737
0012506

Alias epidermal growth factor receptor-binding protein GRB2
similar to Grb3-3 [Mus musculus]
similar to growth factor receptor-bound protein, GRB2 - rat
RT1-149
similar to Grb3 III
similar to Grb3-3
Grb-2
growth factor receptor bound protein 2
Ash
growth factor receptor-bound protein 3
HT027
HT-027
hypothetical protein FLJ20886
abundant SRC homology
EGFRBP-GRB2
Grb3-3
SH2/SH3 adapter GRB2
Grb3-3s
mgc108668
Grb2
GRB2 adapter protein
Growth factor receptor-bound protein 2
Growth factor receptor-bound protein II
FLJ20886
Grb3 III
GRB2_HUMAN
HT(027)
HT 027

Organism Mus musculus
Homo sapiens
Rattus norvegicus
Human

MedLine Reference 12577067
1322798
14722116
8253073
7775428
11152963
11567986
12147689
15569713
15736129
7689150

LocusLink ID 14784
80715
2885
80299
81504
103536
217322
308534
414784

FunctionalClass SH3/SH2 adaptor
epidermal growth factor receptor binding
protein binding

RGD ID 619758

Hugo Symbol GRB2

Unigene ID Rn.3360
Mm.6900
Hs.444356
Rn.122348
Hs.411366
Hs.381152
Rn.40130

Keyword sh-3 domain
sh-2 domain
plasma membrane
desmoplakin
RAS small monomeric GTPase
docking protein
actin
MAP kinase activity
tyrosine kinase receptor
MAP kinase

GO Cellular Component cytoplasm
vesicle membrane
cytosol

GO Molecular Function receptor activity
protein binding activity
SH3/SH2 adaptor protein activity
protein binding

Cell Localization Plasma membrane
Cytoplasm

Pathway p40 MAPK
PDGF signaling
Insulin pathway
IL-6 signaling
IL-3 signaling
IL-2 signaling
IL-1 and IL-6 signaling
Erythropoietin signaling
EGF signaling
CREB signaling
Antiapoptotic Pathways From IGF-1R
MAPK-ERK in Growth and Differentiation
SAPK-JNK Signaling
Jak-Stat Pathway from IL6 Receptor
PTEN signaling
Insulin Receptor Signaling
Integrin Signaling
G-protein Coupled Receptor signaling
NGF signaling
p38 Signaling
Vasopressin
TNF-alpha
Substance P
RANKL
PDGFRB
PDGFRA
Oxytocin
opioids OPRD1
Nociceptin
Neurotensin
LT-alpha
HGF
Gastrin
EPHB1
EPHA2
Endothelin
EGF
Cholecystokinin
Bombesin
ACVR1B -> MADH1 signalling pathway
NGFR -> CEBPB signalling pathway
NOTCH1 -> MYT1 signalling pathway
NOTCH1 -> NFKB2 signalling pathway
NOTCH1 -> LEF1 signalling pathway
NOTCH1 -> HEY1 signalling pathway
NOTCH1 -> HEY2 signalling pathway
NOTCH1 -> E2F1 signalling pathway
NTRK1 -> MYC signalling pathway
NTRK1 -> MYCN signalling pathway
NTRK1 -> FOXO1A signalling pathway
NTRK1 -> FOXO3A signalling pathway
NTRK1 -> CREB1 signalling pathway
NTRK3 -> STAT5A signalling pathway
OPRM1 -> JUNB signalling pathway
OPRM1 -> FOS signalling pathway
OPRM1 -> STAT3 signalling pathway
TEK -> STAT5A signalling pathway
TNFRSF1A -> CREB1 signalling pathway
TRIO -> MYC signalling pathway
ADRB1 -> STAT3 signalling pathway
ADRB2 -> STAT3 signalling pathway
ADRB2 -> CREB1 signalling pathway
ADRB2 -> POU2AF1 signalling pathway
AGTR2 -> IRF1 signalling pathway
VIPR1 -> CREB1 signalling pathway
PTPRU -> CTNNB1 signalling pathway
IFNAR1 -> IRF7 signalling pathway
IFNAR1 -> CDX2 signalling pathway
IL4R -> HMGY signalling pathway
IL6ST -> MYC signalling pathway
IL6ST -> STAT5B signalling pathway
IL7R -> LEF1 signalling pathway
IL7R -> PAX5 signalling pathway
IL9R -> HTATIP signalling pathway
ITGA2B -> BCL3 signalling pathway
BMPR2 -> MADH5 signalling pathway
KIT -> FOS signalling pathway
KIT -> STAT1 signalling pathway
KIT -> STAT3 signalling pathway
KIT -> PAX5 signalling pathway
CCKAR -> FOS signalling pathway
LDLR -> SREBF1 signalling pathway
CD2 -> STAT4 signalling pathway
CD3Z -> VAV1 signalling pathway
CD4 -> VAV1 signalling pathway
CD4 -> STAT6 signalling pathway
CD22 -> VAV1 signalling pathway
CD28 -> HMGY signalling pathway
CD28 -> VAV1 signalling pathway
CD28 -> STAT1 signalling pathway
CD28 -> STAT6 signalling pathway
CD28 -> CREBBP signalling pathway
CD28 -> REL signalling pathway
CD28 -> RELA signalling pathway
CD38 -> MYBL1 signalling pathway
TNFRSF5 -> MYC signalling pathway
EPHA3 -> STAT1 signalling pathway
EPHA3 -> STAT3 signalling pathway
EPHA3 -> TCF3 signalling pathway
EPHA3 -> ELF1 signalling pathway
EPOR -> MYC signalling pathway
EPOR -> SPI1 signalling pathway
EDAR -> EGR1 signalling pathway
FCGR2B -> GATA4 signalling pathway
FCGR3A -> FOS signalling pathway
FGFR1 -> JUN signalling pathway
FGFR1 -> STAT3 signalling pathway
FGFR1 -> CREBBP signalling pathway
FGFR2 -> SOX9 signalling pathway
FLT3 -> HSPCA signalling pathway
GHR -> FOS signalling pathway
GHR -> EGR1 signalling pathway
SSTR1 -> FOS signalling pathway
PECAM1 -> SP1 signalling pathway
PECAM1 -> CTNNB1 signalling pathway
PECAM1 -> RBL2 signalling pathway
CCR5 -> CTNNA1 signalling pathway
CNR1 -> EGR1 signalling pathway
CNR2 -> EGR1 signalling pathway
PRLR -> VAV1 signalling pathway
PRLR -> IRF1 signalling pathway
PTGDR -> EGR1 signalling pathway
PTPRA -> TEAD1 signalling pathway
PTPRE -> MYC signalling pathway
PTPRE -> IRF1 signalling pathway
PTPRE -> EGR1 signalling pathway
DRD3 -> FOS signalling pathway
RET -> STAT3 signalling pathway
RET -> CREB1 signalling pathway
MET -> TP53 signalling pathway
MET -> ETS1 signalling pathway
MET -> FOS signalling pathway
MET -> TAL1 signalling pathway
MET -> CTNNB1 signalling pathway
MET -> EGR1 signalling pathway
MET -> MADH2 signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
AREG-EGFR
BDNF-NCAM1
BDNF-NGFR
BDNF-NTRK1
BDNF-NTRK2
BDNF-NTRK3
BTC-EGFR
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF2-CSF2RA
DTR-EGFR
DTR-ERBB4
EFNB1-EPHB2
EFNB1-FGFR2
EFNB2-EPHB1
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
EPO-EPOR
EREG-EGFR
EREG-ERBB4
FGF1-FGFR2
FGF10-FGFR2
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FGF20-FGFR2
FGF3-FGFR2
FGF4-FGFR2
FGF6-FGFR2
FGF7-FGFR2
FGF8-FGFR2
FIGF-KDR
GDNF-RET
GH1-GHR
GH1-IGF1R
GH1-PRLR
GRO1-EGFR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IL11-IL6R
IL11-IL6ST
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL4-FCER2
IL4-IL2RG
IL4-IL4R
IL5-IL5RA
IL5-IL6ST
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL9-IL9R
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
MUC4-ERBB2
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NRG1-EGFR
NRG1-ERBB2
NRG2-ERBB3
NTF3-CNTFR
NTF3-NGFR
NTF3-NTRK1
NTF3-NTRK2
NTF3-NTRK3
NTF5-NTRK2
NUDT6-FGFR1
OSM-CD22
OSM-IL6ST
OSM-LIFR
PDGFA-PDGFRB
PGF-KDR
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THPO-EPOR
THPO-MPL
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1B
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
VEGFC-FLT1
VEGFC-KDR
CB0479 MAPK
CB0480 Insulin

GO Biological Process MAPKKK cascade
Ras protein signal transduction
cell-cell signaling
epidermal growth factor receptor signaling pathway
intracellular signaling cascade
EGF receptor signaling pathway

Group Sh2

State isoform 1
isoform 2

State Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. It encodes the shorter isoform (2) that lacks an internal segment, as compared to isoform 1.

MGI ID 95805

Swiss-Prot Accession P29354

OMIM ID 108355
OMIM:108355

Source Curated
BIND
ResNet