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Insulin Pathway: HDAC
 | | |  Antibodies to Histones & Histone Deacetylases
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| PhosphoDetect™ Anti-H2AX (pSer139) Rabbit pAb |
IB, IC |
human, mouse |
DR1017 |
| Anti-H2AX Rabbit pAb |
IB, IP |
human, mouse |
DR1016 |
| Anti-HDAC11 Rabbit pAb |
IB |
human, mouse, rat |
ST1139 |
| Anti-Histone Deacetylase 1 (467-482) Rabbit pAb |
IB, IF |
canine, hamster, human, mouse, rat |
PC544 |
| Anti-Histone Deacetylase 2 (475-488) Rabbit pAb |
IB, IC |
canine, hamster, human, mouse, rat |
382153 |
| Anti-Histone Deacetylase 3 (415-428) Rabbit pAb |
IB |
canine, hamster, human, rat |
382154 |
| Anti-Histone Deacetylase 4 (129-137) Rabbit pAb |
IB |
human, mouse |
382161 |
| Anti-Histone Deacetylase 5 (194-206 and 536-545) Rabbit pAb |
IB |
human, mouse (weakly), rat (weakly) |
382162 |
| Anti-Histone Deacetylase 6 (1-16) Rabbit pAb |
IB |
human, mouse |
382163 |
| PhosphoDetect™ Anti-Histone H1 Rabbit pAb |
IB, IC, NOT IP |
bovine, human |
382156 |
| Anti-Histone H3 (1-20) Rabbit pAb |
IB, IC |
human, mouse, rat |
382157 |
| PhosphoDetect™ Anti-Histone H3 (pSer10) (7-20) Rabbit pAb |
IB, IC, IH, IP |
C. elegans, Drosophila, human, Tetrahymena, Xenopus |
382159 |
| Anti-Histone H3, Acetylated (1-20) Rabbit pAb |
IB, IC, IP |
human, Tetrahymena |
382158 |
| Anti-Histone H4, Acetylated (2-19) Rabbit pAb |
IB, IC, IP |
human, Tetrahymena |
382160 |
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| | | Inhibitors
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| Anacardic Acid |
172050 |
| Apicidin, Fusarium sp. |
178276 |
| Histone Acetyltransferase Inhibitor II NEW! |
382110 |
| Histone Deacetylase Inhibitor II |
382148 |
| Histone Deacetylase Inhibitor III |
382149 |
| Histone Deacetylase Inhibitor IV |
382170 |
| Histone Deacetylase Inhibitor I |
382147 |
| ITSA1 |
419840 |
| Oxamflatin |
499700 |
| SBHA |
559418 |
| Scriptaid |
565730 |
| SIRT1 Inhibitor III |
566322 |
| SIRT1/2 Inhibitor IV, Cambinol |
566323 |
| SIRT2 Inhibitor, AGK2 |
566324 |
| SIRT2 Inhibitor, Inactive Control, AGK7 |
566326 |
| Sirtinol |
566320 |
| InSolution™ Sirtinol |
566321 |
| Splitomicin |
567750 |
| Trichostatin A, Streptomyces sp. |
647925 |
| InSolution™ Trichostatin A, Streptomyces sp. |
647926 |
| Valproic Acid, Sodium Salt |
676380 |
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| | | Proteins/Enzymes
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| Histone Deacetylase 8, His•Tag®, Human Recombinant, S. frugiperda |
382184 |
| Histone Deacetylase 9, His•Tag®, Human Recombinant, S. frugiperda |
382186 |
| Histone Deacetylase 5, His•Tag®, Human Recombinant, S. frugiperda |
382178 |
| Histone Deacetylase HD2, Maize |
382168 |
| Histone Deacetylase 2, His•Tag®, Human Recombinant, S. frugiperda |
382174 |
| Histone Deacetylase 7, GST-Fusion, Human, Recombinant, S. frugiperda |
382182 |
| Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda |
382180 |
| Histone Deacetylase, Human, Recombinant, S. frugiperda |
382169 |
| Histone Deacetylase, Rat Liver |
382165 |
| Histone H1, Calf Thymus |
382150 |
| Histone H1.2, Human, Recombinant, E. coli |
382151 |
| Histone, Calf Thymus |
38205 |
| Protamine Sulfate, Salmon Milt |
539122 |
|
| | | | Additional Information | | | | | | | | |
| Protein : HDAC1
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| Name | HDAC1 |
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| Description | histone deacetylase 1 |
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| Owner | Public |
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| URN | urn:agi-llid:3065 |
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| Connectivity | 180 |
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| Notes | Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. |
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| Hugo ID | 4852 |
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| | |
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| Microarray ID | 1448246_at |
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| | 96046_at |
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| | msa.9756.0_f_at |
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| | u80780_s_at |
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| | A_51_P507380 |
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| | 38771_at |
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| | 201209_at |
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| | 476_s_at |
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| | D50405_at |
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| | U50079_s_at |
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| | A_23_P114656 |
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| | A_14_P101381 |
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| | A_14_P132793 |
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| | A_14_P113469 |
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| | CA067 |
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| | OH8261 |
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| | 1388761_at |
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| | 1396820_at |
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| | rc_aa818418_at |
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| | |
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| Chromosome position | 1p34 |
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| | 4 59.0 cM |
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| | 5q36 |
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| | 9q33 |
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| | 17 E2 |
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| | |
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| GO ID | 0000792 |
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| | 0005515 |
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| | 0007492 |
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| | 0016581 |
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| | 0000118 |
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| | 0003700 |
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| | 0004407 |
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| | 0005634 |
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| | 0005737 |
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| | 0006350 |
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| | 0006355 |
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| | 0006916 |
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| | 0008134 |
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| | 0016568 |
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| | 0016575 |
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| | 0016787 |
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| Alias | similar to RPD3 protein |
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| | similar to histone deaceytlase 1 |
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| | similar to putative histone deacetylase |
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| | similar to histone deacetylase 1 |
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| | similar to histone deacetylase I |
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| | similar to histone deacetylase (Takifugu rubripes) |
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| | similar to histone deaceytlase I |
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| | HD I |
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| | HD1 |
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| | Hdac1_predicted |
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| | histone deacetylase 1 |
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| | histone deacetylase I |
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| | reduced potassium dependency, yeast homolog-like I |
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| | HDA1 |
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| | RPD3L I |
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| | HDAC1 |
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| | reduced potassium dependency, yeast homolog-like 1 |
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| | RPD3L1 |
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| | similar to histone deacetylase |
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| | reduced potassium dependency, homolog-like 1 |
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| | reduced potassium dependency, homolog-like I |
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| | reduced potassium dependency, yeast homolog-like |
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| | histone deaceytlase 1 |
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| | putative histone deacetylase |
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| | histone deaceytlase I |
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| | histone deacetylase (Takifugu rubripes) |
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| | RPD3 |
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| | HDAC I |
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| | |
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| Organism | Mus musculus |
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| | Rattus norvegicus |
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| | Homo sapiens |
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| | |
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| FunctionalClass | protein binding |
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| | histone deacetylase |
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| | hydrolase |
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| | transcription factor |
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| | transcription factor binding |
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| KEGG pathway | Cell cycle |
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| | Notch signaling pathway |
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| GO Cellular Component | NuRD complex |
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| | heterochromatin |
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| | cytoplasm |
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| | histone deacetylase complex |
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| | nucleus |
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| Cell Localization | Nucleus |
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| | Cytoplasm |
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| Pathway | INS-EGFR |
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| | INS-HLA-DRB1 |
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| | INS-IGF1R |
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| | INS-TFRC |
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| | TGFB1-ACVR1 |
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| | TGFB1-ACVR1B |
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| | TGFB1-ACVR2 |
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| | TGFB1-ACVR2B |
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| | TGFB1-ACVRL1 |
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| | TGFB1-BMPR1B |
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| | TGFB1-CD44 |
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| | TGFB1-IGF2R |
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| | TGFB1-IL6R |
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| | TGFB1-M6PR |
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| | TGFB1-SELE |
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| | TGFB1-SELL |
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| | TGFB1-TGFBR1 |
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| | TGFB1-TGFBR2 |
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| | TGFB1-TGFBR3 |
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| GO Biological Process | endoderm development |
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| | anti-apoptosis |
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| | chromatin modification |
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| | histone deacetylation |
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| | regulation of transcription, DNA-dependent |
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| | transcription |
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