Insulin Pathway: Insulin-like Growth Factor 1 Receptor (IGF1R)

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IGF1R Antibody/Blocking Peptide

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IGF1R Inhibitor

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Protein : IGF1R


Name	IGF1R
Description	insulin-like growth factor I receptor
Owner	Public
URN	urn:agi-llid:3480
Connectivity	242
Notes	This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Hugo ID	5465


Alias	IGF-1R
	insulin-like growth factor 1 receptor precursor
	Igf1r
	IG1R_HUMAN
	LOC51049
	clone 1900 unknown protein
	IGF1 receptor
	Insulin-like growth factor I receptor
	IGFIRC
	IG1R
	IGF-IR
	IGF-I receptor
	Igf1 receptors
	insulin-like growth factor I receptors
	insulin-like growth factor 1 receptors
	Igf I receptors
	insulin-like growth factor 1 receptor
	JTK13
	similar to insulin receptor-related receptor
	CD221


FunctionalClass	nucleotide binding
	protein binding
	receptor
	transferase
	protein-tyrosine kinase
	insulin-like growth factor binding
	kinase
	protein kinase
	protein serine/threonine kinase
	transmembrane receptor protein tyrosine kinase
	ATP binding
	epidermal growth factor receptor
	insulin-like growth factor receptor


RGD ID	2869


Hugo Symbol	IGF1R


Cell Localization	Plasma membrane
	Cytoplasm


Pathway	Antiapoptotic Pathways From IGF-1R
	Control of skeletal myogenesis
	IGF1R -> MYC signalling pathway
	IGF1R -> MYCN signalling pathway
	IGF1R -> HIF1A signalling pathway
	IGF1R -> TP53 signalling pathway
	IGF1R -> ID2 signalling pathway
	IGF1R -> RUNX2 signalling pathway
	IGF1R -> FOXO1A signalling pathway
	IGF1R -> FOS signalling pathway
	IGF1R -> SREBF1 signalling pathway
	IGF1R -> STAT1 signalling pathway
	IGF1R -> STAT3 signalling pathway
	IGF1R -> STAT5A signalling pathway
	IGF1R -> CEBPA signalling pathway
	IGF1R -> CTNNA1 signalling pathway
	IGF1R -> EGR1 signalling pathway
	GH1-IGF1R
	IGF1-IGF1R
	IGF2-IGF1R
	INS-IGF1R
	CB0480 Insulin
	simple mTOR


GO Biological Process	brain development
	insulin-like growth factor receptor signaling pathway
	male sex determination
	organogenesis
	transmembrane receptor protein tyrosine kinase signaling pathway
	neurite morphogenesis
	anti-apoptosis
	insulin receptor signaling pathway
	positive regulation of cell proliferation
	protein amino acid phosphorylation
	regulation of progression through cell cycle
	signal transduction
	regulation of cell cycle


Group	Kinases
	Receptors


EC Number	2.7.1.112


MGI ID	96433


Swiss-Prot Accession	P08069


OMIM ID	OMIM:147370
	147370


Source	Curated

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