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Insulin Pathway: IRAP
 | | | Currently we do not offer any products for IRAP . Please check back soon.
For additional information on this protein, please refer to the general information provided below. | | | | | | |
| Protein : IRAP (IL1RN)
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| Name | IRAP (IL1RN) |
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| Description | interleukin 1 receptor antagonist |
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| Owner | Public |
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| URN | urn:agi-llid:3557 |
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| Connectivity | 2 |
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| Notes | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
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| Hugo ID | 6000 |
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| Microarray ID | 1387835_at |
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| | 1423017_a_at |
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| | A_51_P307166 |
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| | A_52_P431159 |
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| | X52015 >1 |
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| | X52015 >2 |
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| | 212657_s_at |
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| | 212659_s_at |
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| | 216245_at |
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| | 216243_s_at |
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| | 216244_at |
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| | 31343_at |
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| | 37603_at |
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| | X53296_s_at |
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| | A_14_P112766 |
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| | A_23_P209995 |
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| | A_23_P209990 |
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| | A_32_P38125 |
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| | C38 |
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| | OH8151 |
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| | OR3858 |
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| | RT123 |
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| | MA141 |
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| | m63101cds_at |
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| | A_43_P15503 |
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| Chromosome position | 2q14.2 |
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| | 3p13 |
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| | 2 10.0 cM |
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| GO ID | 0005125 |
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| | 0005150 |
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| | 0009968 |
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| | 0004872 |
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| | 0005149 |
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| | 0005576 |
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| | 0005887 |
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| | 0006629 |
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| | 0006955 |
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| | 0007166 |
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| | 0030073 |
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| | 0005152 |
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| | 0005615 |
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| | 0005622 |
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| | 0006954 |
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| Alias | IRAP |
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| | Il1rn |
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| | IL-1RNs |
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| | interleukin 1 receptor antagonist |
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| | ICIL- 1RA |
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| | IL-1RN |
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| | intracellular IL-1 receptor antagonist type II |
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| | MGC10430 |
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| | IL1X_HUMAN |
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| | F630041P17Rik |
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| | IL1X |
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| | interleukin-1 receptor antagonist secreted form precursor |
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| | IL1F3 |
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| Organism | Mus musculus |
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| | Homo sapiens |
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| | Rattus norvegicus |
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| FunctionalClass | cytokine |
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| | interleukin-1, Type I receptor binding |
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| | interleukin-1 receptor binding |
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| | receptor |
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| | interleukin-1 receptor antagonist |
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| GO Cellular Component | extracellular region |
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| | integral to plasma membrane |
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| | extracellular space |
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| | intracellular |
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| Cell Localization | Extracellular |
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| Pathway | IL1RN-IL1R1 |
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| | CB0480 Insulin |
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| GO Biological Process | cell surface receptor linked signal transduction |
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| | immune response |
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| | insulin secretion |
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| | lipid metabolism |
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| | inflammatory response |
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| | negative regulation of signal transduction |
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| State | isoform 3 |
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| | isoform 2 |
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| | isoform 1 precursor |
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| | isoform 4 |
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| State Description | Transcript Variant: This variant (2) encodes the longest isoform (2). |
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| | Transcript Variant: This variant (3) lacks an inframe coding segment, as compared to variant 2. The resulting isoform (3) lacks an internal region, as compared to the longest isoform (2). |
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| | Transcript Variant: This variant (1) differs in the 5' end compared to variant 2, resulting in an isoform (1) that has a distinct and shorter N-terminus, as compared to the longest isoform (2). |
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| | Transcript Variant: This variant (4) contains a distinct internal exon compared to variant 2. This results in translation from a downstream start codon, and an isoform (4) that has a shorter N-terminus, as compared to the longest isoform (2). |
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