Return to our Home Page


Technical Resources
Technical Information
Calbiochem Information
Interactive Pathways
Protein Tyrosine Kinase
Insulin
Insulin Pathway: IRS 1
 
Antibodies
 
Enzymes
 
Additional Information
 
 
 
 

Protein : IRS1

Name IRS1
Description insulin receptor substrate 1
Owner Public
URN urn:agi-llid:3667
Connectivity 285
Notes SUMMARY: a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism [RGD]
Hugo ID 6125

Microarray ID 1369771_at
rc_aa963662_s_at
x58375_at
A_43_P15254
A_51_P490734
A_52_P171212
A_65_P16645
238933_at
235392_at
41049_at
51048_r_at
47353_at
204686_at
851_s_at
872_i_at
S62539_at
S62539_s_at
S85963_at
850_r_at
rc_aa070752_s_at
A_23_P90649
A_14_P125106
A_14_P108675
A_24_P225679
M357
OR1155
H136
OH2127
RG519

GenBank ID 34877332
6981105
6981106
56503
56504
547740
NT_039172
31753081
386256
386257
547738
2135481
51461028
5031804
5031805
51463854
246465
246466
31753080
51705171
29825828
29825829
26337246
26337247
26095084
21706651
407993
407994
297913
297914
547739
L24563
NC_000067
NM_010570
NP_034700
NT_039173
P35569
X69722
AAA39335
AK045317
AK052241
AK136875
AK141842
AK142242
BAC32308
BAE24991
BC034138
CAA49378
AAB21608
AAB27175
AAH53895
BC053895
NC_000002
NM_005544
NP_005535
NT_005403
NT_086634
P35568
S62539
S85963
CAA41264
NC_005108
NM_012969
NP_037101
NW_047816
P35570
X58375

Chromosome position 9q34
2q36
1 57.0 cM

GO ID 0004872
0005634
0005792
0019901
0004871
0005069
0005158
0005515
0005737
0007165

Alias Irs1
insulin receptor substrate-1
HIRS-1
insulin receptor substrate 1
insulin receptor substrate 3
IRS-1
IRS1_HUMAN
IRS1IRM
insulin receptor substrate I
insulin receptor substrate III
HIRS I
IRS I
Irs3

Organism Mus musculus
Homo sapiens
Rattus norvegicus
Human

MedLine Reference 1648180
8513971
12832401
12878164
14733908
11018022
1311924

LocusLink ID 16367
25467
3667

FunctionalClass protein kinase binding
receptor
insulin receptor binding
protein binding
signal transducer
transmembrane receptor protein tyrosine kinase docking protein

RGD ID 2922

Hugo Symbol IRS1

Unigene ID Hs.471508
Rn.10476
Mm.4952
Hs.390242

GO Cellular Component microsome
nucleus
cytoplasm

Cell Localization Nucleus
Cytoplasm

Pathway Insulin pathway
Antiapoptotic Pathways From IGF-1R
Insulin Receptor Signaling
ACVRL1 -> MADH2 signalling pathway
NGFR -> CEBPB signalling pathway
NOTCH1 -> MYOD1 signalling pathway
NOTCH1 -> FOS signalling pathway
NOTCH1 -> STAT3 signalling pathway
NOTCH1 -> MEF2C signalling pathway
NPHS1 -> JUN signalling pathway
NTRK1 -> MYCN signalling pathway
NTRK1 -> TP53 signalling pathway
NTRK1 -> FOXO3A signalling pathway
NTRK1 -> CREB1 signalling pathway
NTRK3 -> STAT5A signalling pathway
OPRM1 -> JUNB signalling pathway
OPRM1 -> FOS signalling pathway
TEK -> STAT5A signalling pathway
TGFBR1 -> MADH4 signalling pathway
TLR2 -> MHC2TA signalling pathway
TNFRSF1A -> CREB1 signalling pathway
TRIO -> MYC signalling pathway
ADRB1 -> MYC signalling pathway
ADRB2 -> STAT3 signalling pathway
AGTR2 -> IRF1 signalling pathway
ICAM1 -> CREB1 signalling pathway
IFNAR1 -> IRF7 signalling pathway
IFNAR1 -> CDX2 signalling pathway
IGF1R -> MYCN signalling pathway
IL4R -> TP73 signalling pathway
IL4R -> HMGY signalling pathway
IL6ST -> JUN signalling pathway
IL6ST -> CEBPA signalling pathway
IL6ST -> CEBPB signalling pathway
IL7R -> LEF1 signalling pathway
IL7R -> TCF1 signalling pathway
IL7R -> PAX5 signalling pathway
IL9R -> HTATIP signalling pathway
KLRG1 -> FOS signalling pathway
ITGB2 -> CEBPB signalling pathway
KIT -> MYC signalling pathway
KIT -> TP53 signalling pathway
KIT -> HSPCA signalling pathway
KIT -> FOS signalling pathway
KIT -> TAL1 signalling pathway
KIT -> MITF signalling pathway
LEPR -> TCF1 signalling pathway
CD4 -> NFATC2 signalling pathway
CD4 -> STAT5A signalling pathway
CD4 -> CEBPA signalling pathway
CD19 -> JUND signalling pathway
CD28 -> MYC signalling pathway
CD28 -> STAT1 signalling pathway
CD28 -> CREB1 signalling pathway
CD38 -> TCF3 signalling pathway
TNFRSF5 -> TP53 signalling pathway
CD79A -> MYC signalling pathway
EPHA3 -> STAT1 signalling pathway
EPOR -> SPI1 signalling pathway
F2R -> CREB1 signalling pathway
EDAR -> EGR1 signalling pathway
FCGR2B -> YY1 signalling pathway
FCGR3A -> MYC signalling pathway
FCGR3A -> FOS signalling pathway
FGFR1 -> JUN signalling pathway
FGFR1 -> STAT3 signalling pathway
FGFR1 -> CREBBP signalling pathway
FGFR2 -> SOX9 signalling pathway
FLT3 -> FOXO3A signalling pathway
FLT3 -> CEBPA signalling pathway
GHR -> FOS signalling pathway
GHR -> SPI1 signalling pathway
GHR -> EGR1 signalling pathway
SSTR1 -> FOS signalling pathway
CHRNA7 -> CREB1 signalling pathway
CNR1 -> EGR1 signalling pathway
PLAUR -> SP1 signalling pathway
CSF3R -> MYC signalling pathway
PRLR -> VAV1 signalling pathway
PRLR -> IRF1 signalling pathway
PTGDR -> EGR1 signalling pathway
PTPRA -> TEAD1 signalling pathway
DRD1 -> CTNNB1 signalling pathway
DRD3 -> FOS signalling pathway
RET -> STAT3 signalling pathway
EDNRB -> CREB1 signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
BDNF-NCAM1
BDNF-NGFR
BDNF-NTRK1
BDNF-NTRK2
BDNF-NTRK3
CNTF-CNTFR
CNTF-IL6ST
CNTF-LIFR
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
DTR-EGFR
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
GH1-GHR
GH1-IGF1R
GH1-PRLR
GRO1-EGFR
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IGF1-BST1
IGF1-IGF1R
IGF1-IGF2R
IGF1-LRP5
IGF2-IGF1R
IGF2-IGF2R
IL1B-HLA-DRB1
IL1B-IL1R1
IL1B-IL1RAP
IL1B-IL6R
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL4-FCER2
IL4-IL2RG
IL4-IL4R
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL9-IL9R
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
LEP-LEPR
LEP-LRP2
NTF3-CNTFR
NTF3-NGFR
NTF3-NTRK1
NTF3-NTRK2
NTF3-NTRK3
OSM-CD22
OSM-IL6ST
OSM-LIFR
PRL-PRLR
TGFA-EGFR
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1B
VEGF-EGFR
CB0480 Insulin
mTOR
simple mTOR

GO Biological Process signal transduction

Group Ph

MGI ID 99454

Swiss-Prot Accession P35568

OMIM ID OMIM:147545
147545

Source Curated