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Insulin Pathway: IRS 2
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| Anti-IRS-2 (1122-1321) Rabbit pAb |
IB, IP |
hamster, human, mouse, rat |
420293 |
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| | | | Additional Information | | | | | | | | |
| Protein : IRS2
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| Name | IRS2 |
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| Description | insulin receptor substrate 2 |
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| Owner | Public |
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| URN | urn:agi-llid:8660 |
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| Connectivity | 75 |
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| Notes | This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. |
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| Hugo ID | 6126 |
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| Microarray ID | AB000732 >1 |
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| | AB000732 >2 |
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| | AB000732 >3 |
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| | 209184_s_at |
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| | 40181_f_at |
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| | 56338_at |
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| | 48795_at |
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| | 209185_s_at |
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| | 40180_at |
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| | RC_AA101767_at |
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| | A_23_P53838 |
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| | A_14_P137438 |
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| | A_14_P111269 |
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| | A_24_P207003 |
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| | A_24_P154037 |
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| | OH3825 |
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| Chromosome position | 13q34 |
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| | 16q12.5 |
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| | 8 A1.1 |
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| GO ID | 0004872 |
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| | 0007420 |
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| | 0008283 |
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| | 0008286 |
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| | 0019901 |
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| | 0004871 |
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| | 0005158 |
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| | 0006006 |
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| | 0007165 |
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| | 0008284 |
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| Alias | insulin receptor substrate 2 |
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| | IRS-2 |
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| | insulin receptor substrate II |
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| | IRS II |
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| | Irs2 |
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| Organism | Homo sapiens |
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| | Mus musculus |
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| | Rattus norvegicus |
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| FunctionalClass | protein kinase binding |
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| | receptor |
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| | insulin receptor binding |
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| | signal transducer |
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| Cell Localization | Cytoplasm |
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| Pathway | TNFRSF10B -> TP53 signalling pathway |
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| | TLR2 -> MHC2TA signalling pathway |
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| | IFNAR1 -> IRF7 signalling pathway |
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| | IL6R -> CEBPA signalling pathway |
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| | ERBB3 -> MYOG signalling pathway |
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| | ERBB3 -> NFKB1 signalling pathway |
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| | EGF-ERBB2 |
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| | EGF-ERBB3 |
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| | EGF-ERBB4 |
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| | EGF-LRP8 |
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| | EGF-NGFR |
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| | GH1-GHR |
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| | GH1-IGF1R |
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| | GH1-PRLR |
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| | IFNA1-CR2 |
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| | IFNA1-IFNAR1 |
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| | IFNA1-IFNAR2 |
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| | IFNG-HLA-C |
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| | IFNG-IFNGR1 |
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| | IFNG-IFNGR2 |
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| | IGF1-BST1 |
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| | IGF1-IGF2R |
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| | IGF1-LRP5 |
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| | IGF2-IGF1R |
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| | IGF2-IGF2R |
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| | IL10-TNFRSF7 |
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| | IL13-IL13RA1 |
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| | IL13-IL13RA2 |
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| | IL13-IL2RG |
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| | IL15-IL2RB |
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| | IL15-IL2RG |
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| | IL2-IL15RA |
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| | IL2-IL2RA |
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| | IL2-IL2RB |
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| | IL2-IL4R |
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| | IL3-CD8A |
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| | IL3-CSF2RB2 |
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| | IL3-EPOR |
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| | IL3-IL3RA |
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| | IL4-FCER2 |
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| | IL4-IL4R |
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| | IL7-IL2RG |
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| | IL7-IL7R |
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| | IL9-IL9R |
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| | INS-EGFR |
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| | INS-HLA-DRB1 |
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| | INS-TFRC |
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| | LEP-LEPR |
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| | LEP-LRP2 |
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| | LIF-IGF2R |
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| | LIF-IL6ST |
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| | LIF-LIFR |
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| | PRL-PRLR |
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| | TGFA-EGFR |
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| | TGFB1-ACVR1 |
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| | TGFB1-ACVR1B |
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| | TGFB1-ACVR2 |
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| | TGFB1-ACVR2B |
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| | TGFB1-ACVRL1 |
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| | TGFB1-BMPR1B |
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| | TGFB1-CD44 |
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| | TGFB1-IGF2R |
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| | TGFB1-IL6R |
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| | TGFB1-M6PR |
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| | TGFB1-SELE |
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| | TGFB1-SELL |
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| | TGFB1-TGFBR1 |
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| | TGFB1-TGFBR2 |
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| | TGFB1-TGFBR3 |
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| | THPO-EPOR |
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| | THPO-MPL |
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| | TNF-IL15RA |
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| | TNF-NGFR |
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| | TNF-TNFRSF1B |
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| | CB0480 Insulin |
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| GO Biological Process | glucose metabolism |
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| | positive regulation of cell proliferation |
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| | signal transduction |
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| | brain development |
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| | cell proliferation |
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| | insulin receptor signaling pathway |
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