Insulin Pathway: Insulin

�

Insulin Antibody

�

Insulin Kits

�

�

Protein : INS


Name	INS
Description	insulin II
Owner	Public
URN	urn:agi-llid:3630
Connectivity	1060
Notes	After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified.
Hugo ID	6081


FunctionalClass	hormone
	insulin receptor binding


RGD ID	2916


Hugo Symbol	INS


KEGG pathway	Dentatorubropallidoluysian atrophy (DRPLA)
	Regulation of actin cytoskeleton


GO Cellular Component	extracellular
	extracellular space
	nucleus
	small nucleolar ribonucleoprotein complex
	extracellular region


Cell Localization	Extracellular


Pathway	Insulin pathway
	Insulin Receptor Signaling
	IGF1R -> MYC signalling pathway
	IGF1R -> MYCN signalling pathway
	IGF1R -> HIF1A signalling pathway
	IGF1R -> TP53 signalling pathway
	IGF1R -> ID2 signalling pathway
	IGF1R -> RUNX2 signalling pathway
	IGF1R -> FOXO1A signalling pathway
	IGF1R -> FOS signalling pathway
	IGF1R -> SREBF1 signalling pathway
	IGF1R -> STAT1 signalling pathway
	IGF1R -> STAT3 signalling pathway
	IGF1R -> STAT5A signalling pathway
	IGF1R -> CEBPA signalling pathway
	IGF1R -> CTNNA1 signalling pathway
	IGF1R -> EGR1 signalling pathway
	IGF2R -> ELF4 signalling pathway
	CD2 -> MYC signalling pathway
	CD2 -> IRF1 signalling pathway
	CD2 -> GATA3 signalling pathway
	CD2 -> STAT4 signalling pathway
	CD38 -> MYBL1 signalling pathway
	CD38 -> TCF3 signalling pathway
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	CB0480 Insulin
	mTOR
	simple mTOR


GO Biological Process	NOT activation of JUNK
	energy pathways
	ER-overload response
	NOT activation of JNK
	activation of MAPK
	glucose transport
	insulin receptor signaling pathway
	lipid catabolism
	regulation of apoptosis
	regulation of phosphorylation
	activation of JNK
	carbohydrate metabolism
	cell surface receptor linked signal transduction
	cell-cell signaling
	generation of precursor metabolites and energy
	glucose metabolism
	lipid metabolism
	physiological process


Group	Ligands


MGI ID	96573


Swiss-Prot Accession	P01308


Source	Curated