		Technical Resources

		Technical Information

		Calbiochem Information

		Interactive Pathways

		Protein Tyrosine Kinase

		Insulin

Insulin Pathway: JNK

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JNK Antibodies

Product

Application

Species Reactivity

Cat. No.

PhosphoDetect™ Anti-JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb ELISA human PC452

PhosphoDetect™ Anti-JNK1/2 (pThr¹⁸³/Tyr¹⁸⁵) Rabbit pAb IB human, mouse, rat PS1019

PhosphoDetect™ Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb IB, IH C. elegans, chicken, Drosophila, human, mouse, rat 559309

Anti-SAPK/JNK Rabbit pAb IB, IC human, mouse, rat 559304

Anti-SLK Rabbit pAb IB, IP human AP1039

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JNK Assay Kits

Product

Cat. No.

JNK Activity Immunoassay Kit 420115

JNK1/2 ELISA Kit CBA033

PhosphoDetect™ JNK1/2 (pThr¹⁸³/pTyr¹⁸⁵) ELISA Kit CBA007

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� JNK Enzymes

Product

Cat. No.

JNK1, GST-Fusion, Mouse, Recombinant, S. frugiperda 420137

JNK2a2, His•Tag^®, Human, Recombinant, E. coli 420124

JNK, Rat, Recombinant, E. coli 420105

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� JNK Inhibitors

Product

Cat. No.

AEG3482 152228

JNK Inhibitor I, (L)-Form, Cell-Permeable 420116

JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control 420118

JNK Inhibitor II 420119

InSolution™ JNK Inhibitor II 420128

JNK Inhibitor II, Negative Control 420123

JNK Inhibitor III, Cell-Permeable 420130

JNK Inhibitor III, Cell-Permeable, Negative Control 420131

JNK Inhibitor V 420129

JNK Inhibitor VI, TI-JIP_153-163 420133

JNK Inhibitor VII, TAT-TI-JIP_153-163, Cell-Permeable 420134

JNK Inhibitor VIII 420135

JNK Inhibitor IX 420136

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� JNK Peptides/Substrates

Product

Cat. No.

JNK Substrate, c-Jun 1-79 420108

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Additional Information

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Protein : JNK1 (MAPK8)


Name	JNK1 (MAPK8)
Description	mitogen activated protein kinase 8
Owner	Public
URN	urn:agi-llid:5599
Connectivity	327
Notes	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Hugo ID	6881


Microarray ID	rc_AI029013_at
	100391_at
	A_43_P15745
	L26318
	34006_s_at
	56901_at
	210477_x_at
	210671_x_at
	226046_at
	226048_at
	229664_at
	2071_s_at
	U35005_s_at
	2070_i_at
	84382_at
	A_23_P356152
	A_14_P128899
	A_14_P122151
	A_14_P107815
	A_23_P202540
	A_24_P286898
	R637
	702
	OH7871
	136576_r_at
	1420931_at
	A_51_P357182
	A_51_P422342
	A_65_P05523
	A_65_P05437
	A_52_P657817
	A_52_P559044
	L27129_at
	L27129.1
	104047_at
	1420932_at
	1437045_at
	132248_r_at
	170626_i_at
	NM_016700
	AK047936
	H3066H10-3
	NM_002750.2
	I_932382


GenBank ID	AK156633
	BAB26834
	BAE25995
	BAE33785
	BC021788
	NC_000075
	NM_028030
	NP_082306
	NT_039474
	AK144659
	AAH21788
	AK010301
	AAA42111
	L27129
	NC_005115
	NW_047469
	P49185
	XM_341399
	XP_341400
	AK039129
	AK039254
	AK043102
	AAH53027
	AB005663
	AK030767
	AK032486
	AK044768
	AK047936
	AK053062
	AK085745
	AK139498
	AK162915
	BAA85875
	BAC31460
	BC053027
	NC_000080
	NM_016700
	NP_057909
	NT_039606
	Q91Y86
	AAA36131
	AAC50607
	AAC50610
	AAC50611
	AL137667
	L26318
	NC_000010
	NM_002750
	NM_139046
	NM_139047
	NM_139049
	NP_002741
	NP_620634
	NP_620635
	NP_620637
	NT_017696
	NT_086769
	P45983
	U34822
	U35004
	U35005
	51768363
	31980670
	6141550
	6141551
	26086964
	26087040
	26335518
	26335519
	26090526
	26092533
	26095546
	31418523
	31418524
	22653814
	4506095
	AK125150
	A53063
	29737804
	20986493
	20986518
	20986519
	20986520
	20986521
	20986522
	20986523
	51468195
	6807833
	474900
	474901
	1463130
	1463131
	1463136
	1463137
	1463138
	1463139
	2507195
	1082748
	7710060
	34877248
	34877032
	34877033
	493212
	493213
	1346337
	NT_039598
	H3073D04-3
	H3066H10-3
	5730585A15
	D730034N23


Chromosome position	14 B
	9 C
	10q11.22
	16p16


GO ID	GO:0004707
	GO:0004691
	GO:0004682
	GO:0005524
	0003676
	0003723
	0004682
	0004691
	0005634
	0006355
	0004672
	0004713
	0016301
	0000166
	0004674
	0004705
	0004707
	0005515
	0005524
	0006468
	0006928
	0006950
	0007165
	0007254
	0016740
	GO:0004674
	GO:0004672
	GO:0016740
	GO:0007254
	GO:0006468
	GO:0006355
	GO:0007165
	GO:0005634
	GO:0004713
	GO:0016301
	GO:0006950
	GO:0006928
	GO:0004705


Alias	JNK1 alpha protein kinase
	JNK1 alpha2 protein kinase
	JNK1A2
	mitogen activated protein kinase 8
	PRKM8
	protein kinase JNK1
	Stress-activated protein kinase JNK1
	JNK-46
	PIR:A53063
	protein kinase mitogen-activated 8
	mitogen activated protein kinase VIII
	protein kinase mitogen-activated VIII
	similar to RIKEN cDNA 2400008B06
	c-Jun N-terminal kinase I
	expressed sequence AI849689
	c-Jun N-terminal kinase
	MAPK8
	SAPK1
	SAPK I
	JNK I
	Stress-activated protein kinase JNK I
	JNK
	Pia I
	Pristane induced arthritis QTL 1
	Pia1
	Pristane induced arthritis QTL I
	mitogen-activated protein kinase 8
	stress-activated protein kinase JNK1
	JNK1-alpha-1
	JNK1alpha2
	c-Jun NH2-kinase
	AI849689
	JNK1 beta protein kinase
	Jun N-terminal kinase
	JNK1
	JNK21B1/2
	RBPMS2
	RNA-binding protein with multiple splicing 2
	RNA-binding protein with multiple splicing II
	c-jun NH2-terminal kinase
	protein kinase JNK I
	RBPMS2s
	c-Jun N-terminal kinase 1


Organism	Rattus norvegicus
	Mus musculus
	Homo sapiens
	Human


MedLine Reference	12011047
	12839624
	12970181
	12466851
	12808090
	10490659
	10912793
	11238452
	8137421
	8654373


LocusLink ID	326419
	102478
	5599
	71973
	105560
	19098
	26419
	50656
	116554


FunctionalClass	RNA binding
	nucleic acid binding
	cAMP-dependent protein kinase
	protein kinase CK2
	kinase
	protein kinase
	protein-tyrosine kinase
	ATP binding
	JUN kinase
	MAP kinase
	nucleotide binding
	protein binding
	protein serine/threonine kinase
	transferase


RGD ID	621506
	61411


Hugo Symbol	MAPK8


Unigene ID	Rn.4090
	Mm.21495
	Hs.522924
	Hs.445864
	Hs.267445


KEGG pathway	Wnt signaling pathway
	Focal adhesion
	MAPK signaling pathway
	Toll-like receptor signaling pathway


Keyword	map kinase
	SAP kinase
	protein phosphatase
	map kinase kinase
	nucleus
	synaptosome
	PKC
	map kinases
	phosphotransferase
	nuclei
	RNA
	ERK activator kinase


GO Cellular Component	nucleus


GO Molecular Function	JUN kinase activity
	MAP kinase activity
	cAMP-dependent protein kinase activity
	protein kinase CK2 activity
	ATP binding
	protein serine/threonine kinase activity
	protein kinase activity
	transferase activity
	protein-tyrosine kinase activity
	kinase activity
	protein tyrosine kinase activity
	ATP binding activity


Cell Localization	Nucleus
	Cytoplasm


Pathway	Jnk-mapk
	PDGF signaling
	Insulin pathway
	IL-2 signaling
	FAS signaling
	Erythropoietin signaling
	EGF signaling
	Death receptor signaling
	ATM signaling
	SAPK-JNK Signaling
	Jak-Stat Pathway from IL6 Receptor
	Integrin Signaling
	Apoptosis
	NGF signaling
	Wnt signaling
	TNFR1 signaling
	Toll-Like Receptor pathway
	ACVR1B -> JUNB signalling pathway
	TNFRSF14 -> JUN signalling pathway
	NOTCH1 -> SPI1 signalling pathway
	NOTCH4 -> HEY1 signalling pathway
	NTRK2 -> JUN signalling pathway
	TLR4 -> IRF3 signalling pathway
	TLR4 -> JUN signalling pathway
	TNFRSF1A -> ZFP36 signalling pathway
	TNFRSF1A -> JUN signalling pathway
	TNFRSF1A -> ATF2 signalling pathway
	TNFRSF1B -> JUN signalling pathway
	TRIO -> MYC signalling pathway
	TNFRSF4 -> JUN signalling pathway
	AGTR1 -> JUN signalling pathway
	AGTR1 -> STAT1 signalling pathway
	AGTR2 -> MYC signalling pathway
	AGTR2 -> JUN signalling pathway
	AGTR2 -> PAX2 signalling pathway
	ICAM1 -> TFAP2A signalling pathway
	ICAM1 -> JUN signalling pathway
	TNFRSF6 -> HIF1A signalling pathway
	TNFRSF6 -> BCL6 signalling pathway
	TNFRSF6 -> JUN signalling pathway
	TNFRSF6 -> SREBF1 signalling pathway
	TNFRSF6 -> ATF2 signalling pathway
	TNFRSF6 -> E2F1 signalling pathway
	IL4R -> MYC signalling pathway
	IL6R -> JUNB signalling pathway
	IL6ST -> MYC signalling pathway
	IL6ST -> JUNB signalling pathway
	ITGAM -> JUN signalling pathway
	ITGAM -> SPI1 signalling pathway
	BMPR1A -> DLX5 signalling pathway
	CD4 -> JUNB signalling pathway
	CD22 -> MYC signalling pathway
	CD22 -> JUN signalling pathway
	CD28 -> JUN signalling pathway
	TNFRSF8 -> MYC signalling pathway
	TNFRSF5 -> BCL6 signalling pathway
	TNFRSF5 -> JUN signalling pathway
	TNFRSF5 -> CEBPA signalling pathway
	TNFRSF5 -> FOSL1 signalling pathway
	EPHA1 -> JUN signalling pathway
	EPOR -> SPI1 signalling pathway
	TNFRSF19 -> JUN signalling pathway
	F2R -> JUN signalling pathway
	EDAR -> JUN signalling pathway
	FCGR3A -> MYC signalling pathway
	FLT3 -> SPI1 signalling pathway
	GHR -> SPI1 signalling pathway
	EDG5 -> JUN signalling pathway
	CSF3R -> SPI1 signalling pathway
	PTPRA -> TEAD1 signalling pathway
	PTPRE -> MYC signalling pathway
	DRD1 -> JUNB signalling pathway
	EGFR -> PAX2 signalling pathway
	EPHA2 -> TP53 signalling pathway
	AGT-LRP2
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	BMP2-ACVR1
	BMP2-ACVR2
	BMP2-BMPR1A
	BMP2-BMPR1B
	BMP2-BMPR2
	BMP4-ACVR1
	BMP4-BMPR1A
	BMP4-BMPR1B
	BMP4-BMPR2
	BMP7-ACVR1
	BMP7-ACVR2
	BMP7-ACVR2B
	BMP7-BMPR1A
	BMP7-BMPR1B
	BMP7-BMPR2
	CCL2-CD4
	CCL4-CD4
	CCL4-TNFRSF8
	CD86-CD28
	CD86-CD80
	CD86-CR1
	CD86-CR2
	CD86-TNFRSF5
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF2-CSF2RA
	CSF3-CSF3R
	CSF3-IL6R
	EFNB1-EPHB2
	EFNB1-FGFR2
	EFNB2-EPHB1
	EGF-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	EPO-EPOR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	FGF7-FGFR2
	FGF7-GPC1
	GDNF-RET
	GH1-GHR
	GH1-IGF1R
	GH1-PRLR
	GRO1-EGFR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IFNB1-IFNAR1
	IFNB1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	IGF2-IGF1R
	IGF2-IGF2R
	IL10-IL10RA
	IL10-TNFRSF7
	IL13-IL13RA1
	IL13-IL13RA2
	IL13-IL2RG
	IL13-IL4R
	IL16-CD4
	IL17-IL17R
	IL1A-IL1R1
	IL1A-IL1RAP
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL2-IL15RA
	IL2-IL2RA
	IL2-IL2RB
	IL2-IL2RG
	IL2-IL4R
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL5-IL5RA
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	IL7-IL2RG
	IL7-IL7R
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	INS-EGFR
	INS-HLA-DRB1
	INS-IGF1R
	INS-TFRC
	KITLG-KIT
	LEP-LEPR
	LEP-LRP2
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	MDK-ITGB1
	MDK-LRP2
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NPPA-NPTXR
	NRG1-CD44
	NRG1-EGFR
	NRG1-ERBB2
	NRG1-ERBB3
	NRG1-ERBB4
	NTF3-CNTFR
	NTF3-NGFR
	NTF3-NTRK1
	NTF3-NTRK2
	NTF3-NTRK3
	OSM-CD22
	OSM-IL6ST
	OSM-LIFR
	PGF-FLT1
	PGF-KDR
	PRL-PRLR
	PTH-IL6ST
	SDF1-CD4
	SDF1-IL6ST
	SPP1-CD44
	SPP1-ITGAV
	TGFA-EGFR
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	THBS1-CD36
	THBS1-ITGB1
	THBS1-VLDLR
	THPO-EPOR
	THPO-MPL
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1A
	TNF-TNFRSF1B
	TNF-TNFRSF6
	TNFSF10-TNFRSF10A
	TNFSF10-TNFRSF10B
	TNFSF10-TNFRSF1A
	TNFSF10-TNFRSF6
	TNFSF11-TNFRSF11A
	TNFSF11-TNFRSF11B
	TNFSF13B-TNFRSF13B
	TNFSF13B-TNFRSF13C
	TNFSF13B-TNFRSF17
	TNFSF5-CD28
	TNFSF5-CD80
	TNFSF5-TNFRSF5
	TNFSF5-TNFRSF6
	TNFSF5-TNFRSF7
	TNFSF5-TNFRSF8
	TNFSF6-TNFRSF6
	VEGF-CD44
	VEGF-EGFR
	VEGF-FLT1
	VEGF-FLT4
	VEGF-GPC1
	VEGF-IL1R1
	VEGF-KDR
	WNT1-ROR2
	CB0479 MAPK
	CB0480 Insulin


GO Biological Process	regulation of transcription, DNA-dependent
	JNK cascade
	cell motility
	protein amino acid phosphorylation
	response to stress
	signal transduction


Group	Kinases


EC Number	2.7.1.37
	2.7.1.-


State	isoform 2
	isoform 3
	isoform 4
	isoform 1
	p


State Description	Transcript Variant: This variant (1) is also known as JNK1 alpha1. It encodes the longest isoform (1).
	Transcript Variant: This variant (2) is also known as JNK1 alpha2. It contains extra 5 nt within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) thus contains a distinct and shorter C-te...
	Transcript Variant: This variant (3) is also known as JNK1 beta 1. It contains a different segment, and extra 5 nt within the coding region, when compared to variant 1. The extra 5 nt leads to a translation frameshift, and results in an isoform (1) tha...
	Transcript Variant: This variant (4) is also known as JNK1 beta2. It contains a different segment within the coding region when compared to variant 1. The translation remains in-frame, and results in an isoform (4) that contains a different internal se...


MGI ID	1346861


Swiss-Prot Accession	P45983


OMIM ID	601158
	61411
	OMIM:601158


Source	Curated
	BIND
	ResNet

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