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Technical Information
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Interactive Pathways
Protein Tyrosine Kinase
Insulin
Insulin Pathway: PDK1
 
PDK1 Antibodies
 
PDK1 Proteins/Enzymes
 
Additional Information
 
 
 
 

Protein : PDK1 (PDPK1)

Name PDK1 (PDPK1)
Description 3-phosphoinositide dependent protein kinase-1
Owner Public
URN urn:agi-llid:5170
Connectivity 157
Notes SUMMARY: may catalyze the phosphorylation and activation of protein kinase B [RGD]
Hugo ID 8816

Microarray ID 1370052_at
y15748_at
A_43_P12504
102063_at
134947_r_at
1416501_at
msa.34345.0_s_at
A_51_P207140
A_52_P619138
Y15056
222260_at
32029_at
73168_s_at
204524_at
224986_s_at
232050_at
RC_AA041276_at
rc_aa019394_at
221244_s_at
64052_at
rc_aa488978_at
A_14_P128757
A_23_P66219
A_14_P107472
A_14_P120883
A_24_P830690
A_14_P123854
A_24_P222599
A_32_P344843
A_23_P10614
A_24_P37441
OH8695
CA422
OH2464
OR3282
RA1061

GenBank ID 47680172
BC000789
BC006339
BC012103
BC012540
BC033494
BC040324
BI830733
CAA75341
CAG38755
CR536517
NC_000016
NM_002613
NM_031268
NP_002604
NP_112558
NT_037887
NT_086834
O15530
Q9UI25
Y15056
CAA75758
NC_005109
NM_031081
NP_112343
NW_047334
O55173
Y15748
AAC67544
AAC96115
AAD38505
AAL47185
AAO17164
AF079535
AF086625
AF126294
AK047229
AK147149
AK147835
AK149162
AK149289
AK162677
AK165564
AK188106
AK205439
AK215448
AK219503
AY062008
AY162410
BAE27716
BAE28171
BAE28793
BAE37017
NC_000083
NM_011062
NP_035192
NT_039649
Q9Z2A0
AAC33797
AAC33798
AAC51825
AAF16685
AAH06339
AAH12103
AAH33494
AB209835
AC005591
AF017995
AF111845
AK095507
AK131060
AK222581
AL157446
BAD93072
BAD96301
4505695
47680168
47680169
51473214
3513293
3513294
3513295
2407612
2407613
6560611
6560612
21754775
34528313
7018448
13937557
33873510
33873511
15082378
15082379
15214808
23271394
23271395
26007919
15942283
49168519
49168520
2505935
2505936
17380162
9910796
51770238
6755019
6755020
4028126
4028127
3789924
3789925
5052327
5052328
21632794
21632795
18203660
34872015
13592022
13592023
2665355
2665356
18202068
NM_002610
51473210

Chromosome position 16p13.3
10q12
17 A3.3

GO ID 0008286
0000287
0004682
0004691
0004713
0030295
0004672
0004674
0006972
0007165
0016020
0016023
0016301
0000166
0004676
0005524
0005737
0005886
0006468
0016740
0030036

Alias pkb kinase like gene 1
pkb kinase like gene I
pkb-like
pkb-like 1
pkb-like I
3-phosphoinositide dependent protein kinase-1
Phosphoinositide-dependent kinase 1
MGC20087
MGC35290
PDPK I
hPDK I
PDPK1
Pdk1
PDK-1
PIP3
hPDK1
PkB kinase
PRO0461
3-phosphoinositide dependent protein kinase I
Pdk I

Organism Mus musculus
Rattus norvegicus
Homo sapiens
Human

MedLine Reference 10792047
9368760
9637919
9445477
10075713
12783890

LocusLink ID 5170
81745
18607
28993

FunctionalClass kinase
protein kinase
cAMP-dependent protein kinase
magnesium ion binding
protein kinase CK2
protein kinase activator
protein-tyrosine kinase
protein serine/threonine kinase
3-phosphoinositide-dependent protein kinase
ATP binding
nucleotide binding
transferase

RGD ID 620307

Hugo Symbol PDPK1

Unigene ID Hs.154729
Mm.10504
Rn.10905
Hs.459691

KEGG pathway Focal adhesion

GO Cellular Component cytoplasmic membrane-bound vesicle
membrane
cytoplasm
plasma membrane
cytoplasmic vesicle

Cell Localization Cytoplasm
Plasma membrane

Pathway CREB signaling
AKT signaling
Antiapoptotic Pathways From IGF-1R
PTEN signaling
Insulin Receptor Signaling
Apoptosis
Mitochondrial control of Apoptosis
Inhibition of Apoptosis
TNFRSF5 -> FOXO1A signalling pathway
AGT-LRP2
BMP4-ACVR1
BMP4-BMPR1B
BMP4-BMPR2
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
IGF1-BST1
IGF1-IGF2R
IGF1-LRP5
INS-EGFR
INS-HLA-DRB1
INS-TFRC
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1B
CB0479 MAPK
CB0480 Insulin
mTOR
simple mTOR

GO Biological Process hyperosmotic response
signal transduction
actin cytoskeleton organization and biogenesis
insulin receptor signaling pathway
protein amino acid phosphorylation

Group Kinases
Ph

EC Number 2.7.1.37

MGI ID 1338068

Swiss-Prot Accession O15530

OMIM ID OMIM:605213
605213

Source Curated