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Insulin Pathway: PPARg
 | | |  PPARg Antibodies
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| Anti-PGC-1, C-Terminal (777-797) Rabbit pAb |
ELISA, IB, IH |
human, mouse |
516557 |
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| | | PPARg Activators
| | | PPARg Antagonist
| | | | Additional Information | | | | | | | | |
| Protein : PPARG
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| Name | PPARG |
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| Description | Peroxisome proliferator activated receptor gamma; peroxisome proliferator activator receptor gamma 2. PPAR-gamma plays a key role in cell differentiation. |
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| Owner | Public |
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| URN | urn:agi-llid:5468 |
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| Connectivity | 188 |
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| Notes | The protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Multiple transcript variants that use alternate promoters and splicing have been identified for this gene. At least three of these variants encode the same isoform. |
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| Hugo ID | 9236 |
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| Microarray ID | 1369179_a_at |
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| | ab011365_s_at |
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| | 97926_s_at |
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| | u09138_s_at |
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| | A_51_P106799 |
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| | A_65_P08106 |
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| | U63415 |
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| | 208510_s_at |
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| | 37104_at |
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| | L40904_at |
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| | A_23_P252062 |
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| | A_14_P107054 |
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| | A_14_P131601 |
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| | A_14_P139078 |
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| | A_14_P139446 |
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| | OR2771 |
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| | OH2720 |
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| | RT004 |
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| | T59 |
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| | rc_ai012992_s_at |
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| | A_43_P14941 |
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| | A_42_P462474 |
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| | 1420715_a_at |
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| Chromosome position | 4q42 |
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| | 6 52.7 cM |
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| | 3p25 |
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| GO ID | 0006631 |
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| | 0045598 |
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| | 0003677 |
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| | 0004872 |
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| | 0004879 |
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| | 0005829 |
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| | 0006355 |
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| | 0006954 |
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| | 0016563 |
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| | 0016564 |
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| | 0017053 |
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| | 0030855 |
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| | 0045165 |
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| | 0045444 |
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| | 0045449 |
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| | 0045892 |
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| | 0045944 |
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| | 0003700 |
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| | 0003707 |
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| | 0005515 |
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| | 0005634 |
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| | 0006091 |
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| | 0006350 |
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| | 0006357 |
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| | 0006629 |
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| | 0007165 |
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| | 0007584 |
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| | 0046872 |
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| | 0050872 |
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| | 0000122 |
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| Alias | PPAR-gamma |
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| | PPAR-gamma2 |
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| | peroxisome proliferative activated receptor gamma isoform 1 |
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| | PPARG I |
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| | PPARG1s |
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| | PPARG2s |
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| | PPARG Is |
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| | HUMPPARG |
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| | NR1C3 |
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| | peroxisome proliferative activated receptor gamma isoform 2 |
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| | peroxisome proliferative activated receptor, gamma |
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| | Peroxisome proliferator activated receptor gamma |
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| | PPAR gamma |
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| | PPARG1 |
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| | PPARG2 |
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| | peroxisome proliferative activated receptor gamma isoform I |
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| | peroxisome proliferative activated receptor gamma isoform II |
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| | Pparg |
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| | peroxisome proliferator activated receptor, gamma |
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| | peroxisome proliferator activator receptor gamma |
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| | peroxisome proliferator activator receptor, gamma |
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| | peroxisome proliferator activator receptor gamma 2 |
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| Organism | Homo sapiens |
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| | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| FunctionalClass | ligand-dependent nuclear receptor |
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| | DNA binding |
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| | metal ion binding |
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| | protein binding |
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| | steroid hormone receptor |
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| | transcription factor |
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| | receptor |
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| | transcriptional activator |
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| | transcriptional repressor |
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| GO Cellular Component | nucleus |
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| | cytosol |
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| | transcriptional repressor complex |
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| Cell Localization | Plasma membrane |
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| | Nucleus |
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| Pathway | p40 MAPK |
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| | MAPK-ERK in Growth and Differentiation |
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| GO Biological Process | generation of precursor metabolites and energy |
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| | lipid metabolism |
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| | regulation of transcription from RNA polymerase II promoter |
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| | response to nutrients |
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| | signal transduction |
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| | transcription |
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| | white fat cell differentiation |
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| | fatty acid metabolism |
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| | regulation of fat cell differentiation |
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| | cell fate commitment |
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| | epithelial cell differentiation |
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| | fat cell differentiation |
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| | inflammatory response |
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| | negative regulation of transcription from RNA polymerase II promoter |
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| | negative regulation of transcription, DNA-dependent |
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| | positive regulation of transcription from RNA polymerase II promoter |
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| | regulation of transcription |
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| | regulation of transcription, DNA-dependent |
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| | adipocyte differentiation |
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| | negative regulation of transcription from Pol II promoter |
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| | positive regulation of transcription from Pol II promoter |
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| | regulation of adipocyte differentiation |
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| | regulation of transcription from Pol II promoter |
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| | white adipocyte differentiation |
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| | energy pathways |
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| State | peroxisome proliferative activated receptor gamma isoform 1 |
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| | peroxisome proliferative activated receptor gamma isoform 2 |
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| State Description | Transcript Variant: This variant (4) lacks an internal region of the 5' UTR as compared to variant 1. Variants 1, 3 and 4 encode the same isoform, 1. |
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| | Transcript Variant: This variant (2) has an alternate 5' end sequence as compared to variant 1. Variant 2 encodes the longest isoform, 2, which has a unique amino terminus. |
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| | Transcript Variant: This variant (3) lacks the terminal 5' UTR sequence of variant 1 and instead has a unique sequence at the 5' end. Variants 1, 3 and 4 encode the same isoform, 1. |
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| | Transcript Variant: This variant (1) contains the longest 5' UTR and encodes the same isoform as variants 3 and 4. |
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