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Insulin Pathway: PTEN
 | | |  PTEN Antibodies
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| Anti-PTEN Mouse mAb (EMD-4B8) |
IB, NOT IP |
human |
AP1042 |
| Anti-PTEN Mouse mAb (EMD-15E10) |
ELISA, IP, NOT IB |
human |
AP1041 |
| PhosphoDetect™ Anti-PTEN (pSer380) Rabbit pAb |
IB, IC, IP, PS |
human, mouse, rat |
ST1072 |
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| | | PTEN Inhibitors
| | | PTEN Protein
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| PTEN, His•Tag® and S•Tag™, Human Recombinant, S. frugiperda |
481409 |
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| | | | Additional Information | | | | | | | | |
| Protein : PTEN
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| Name | PTEN |
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| Description | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) |
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| Owner | Public |
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| URN | urn:agi-llid:5728 |
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| Connectivity | 159 |
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| Notes | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. |
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| Hugo ID | 9588 |
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| Microarray ID | 1370112_at |
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| | rc_aa963447_at |
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| | rc_ai176021_at |
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| | A_43_P12611 |
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| | 103019_at |
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| | 1422553_at |
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| | 160614_at |
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| | u92437_s_at |
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| | 1418196_at |
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| | 93367_at |
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| | u86137_s_at |
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| | A_51_P275350 |
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| | A_65_P10583 |
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| | A_51_P506755 |
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| | A_52_P560996 |
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| | U96180 |
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| | 227469_at |
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| | 39552_at |
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| | 204054_at |
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| | 211711_s_at |
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| | 204053_x_at |
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| | 225363_at |
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| | 228006_at |
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| | 242622_x_at |
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| | 1434_at |
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| | 31675_s_at |
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| | 217492_s_at |
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| | U92436_at |
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| | 217494_s_at |
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| | 39553_at |
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| | A_23_P98085 |
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| | A_14_P112505 |
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| | A_14_P104130 |
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| | A_14_P105028 |
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| | A_24_P252785 |
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| | OR1980 |
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| | N253 |
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| | OH8531 |
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| | RT069 |
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| | V250 |
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| Chromosome position | 19 24.5 cM |
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| | 10q23.3 |
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| GO ID | 0004721 |
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| | 0006917 |
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| | 0007417 |
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| | 0007507 |
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| | 0016477 |
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| | 0004725 |
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| | 0006470 |
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| | 0007049 |
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| | 0008138 |
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| | 0016314 |
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| | 0016787 |
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| | 0045786 |
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| | 0004437 |
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| | 0005161 |
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| | 0008285 |
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| | 0030336 |
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| | 0031175 |
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| | 0046855 |
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| | 0048008 |
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| Alias | A130070J02Rik |
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| | MGC11227 |
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| | phosphatase and tensin homolog deleted on chromosome ten |
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| | MMAC I |
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| | protein tyrosine phosphatase and tensin-like protein |
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| | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) |
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| | TEP1 |
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| | 2310035O07Rik |
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| | RIKEN cDNA 2310035O07 gene |
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| | MHAM |
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| | Mutated in multiple advanced cancers 1 |
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| | phosphatase and tensin homolog |
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| | Protein-tyrosine phosphatase PTEN |
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| | PTEN1 |
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| | multiple hamartoma |
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| | Mutated in multiple advanced cancers I |
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| | MMAC1 |
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| | PTEN |
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| | PTEN I |
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| | TEP I |
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| | Bannayan-Zonana syndrome protein |
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| | Bannayan-Zonana syndrome |
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| | Mmac |
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| | mutated in multiple advanced cancers 1 |
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| | MMAC1 phosphatase and tension homolog deleted on chromosome 10 |
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| | BZS |
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| | multiple hamartoma (Cowden syndrome) |
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| Organism | Homo sapiens |
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| | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| FunctionalClass | hydrolase |
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| | phosphoprotein phosphatase |
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| | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
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| | protein tyrosine phosphatase |
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| | protein tyrosine/serine/threonine phosphatase |
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| | inositol or phosphatidylinositol phosphatase |
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| | platelet-derived growth factor receptor binding |
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| KEGG pathway | Focal adhesion |
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| | Inositol phosphate metabolism |
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| | Phosphatidylinositol signaling system |
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| | Tight junction |
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| Cell Localization | Cytoplasm |
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| Pathway | PTEN signaling |
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| | Insulin Receptor Signaling |
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| | BDNF-NCAM1 |
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| | BDNF-NTRK2 |
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| | BDNF-NTRK3 |
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| | BMP2-ACVR2 |
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| | IL3-CD8A |
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| | IL3-CSF2RB2 |
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| | IL3-EPOR |
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| | IL3-IL3RA |
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| | INS-EGFR |
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| | INS-HLA-DRB1 |
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| | INS-TFRC |
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| | NGFB-NTRK2 |
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| | NGFB-NTRK3 |
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| | TGFB1-ACVR1 |
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| | TGFB1-ACVR1B |
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| | TGFB1-ACVR2 |
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| | TGFB1-ACVR2B |
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| | TGFB1-ACVRL1 |
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| | TGFB1-BMPR1B |
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| | TGFB1-CD44 |
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| | TGFB1-IGF2R |
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| | TGFB1-IL6R |
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| | TGFB1-M6PR |
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| | TGFB1-SELE |
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| | TGFB1-SELL |
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| | TGFB1-TGFBR1 |
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| | TGFB1-TGFBR2 |
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| | TGFB1-TGFBR3 |
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| | TNF-IL15RA |
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| | TNF-NGFR |
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| | TNF-TNFRSF1B |
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| | TNFSF11-TNFRSF11B |
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| | CB0480 Insulin |
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| | simple mTOR |
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| GO Biological Process | inositol phosphate dephosphorylation |
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| | negative regulation of cell migration |
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| | negative regulation of cell proliferation |
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| | neurite morphogenesis |
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| | platelet-derived growth factor receptor signaling pathway |
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| | cell migration |
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| | central nervous system development |
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| | heart development |
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| | induction of apoptosis |
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| | cell cycle |
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| | negative regulation of progression through cell cycle |
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| | protein amino acid dephosphorylation |
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| | negative regulation of cell cycle |
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