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Insulin Pathway: RAF
 
RAF Antibodies
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Anti-A-Raf Protein Kinase, C-Terminal (584-597) Rabbit pAb ELISA, IB, IP human, mouse, rat 553001
PhosphoDetect™ Anti-c-Raf (pSer621) Mouse mAb (6B4) ELISA, IB human 553010
PhosphoDetect™ Anti-c-Raf (pTyr340, Tyr341) Rabbit pAb IB, IC human, mouse, rat 553009
PhosphoDetect™ Anti-Raf (pSer259) Rabbit pAb IB, IP, PS human, mouse, rat ST1076
Anti-Raf1 (Ab-2) (380-403) Rabbit pAb IB human, mouse PC91
 
RAF Inhibitors
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Raf Kinase Inhibitor III 553013
Raf Kinase Inhibitor IV 553014
Raf1 Kinase Inhibitor I 553008
InSolution™ Raf1 Kinase Inhibitor I 553003
ZM 336372 692000
 
Additional Information
 
 
 
 

Protein : RAF1

Name RAF1
Description v-raf-1 murine leukemia viral oncogene homolog 1
Owner Public
URN urn:agi-llid:5894
Connectivity 302
Notes Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. [Contributed text]
Hugo ID 9829
Microarray ID 1369932_a_at
m15427_s_at
A_43_P11498
1416078_s_at
1420090_at
1425419_a_at
160157_at
94264_at
msa.24413.0_s_at
msa.4872.0_f_at
msa.6334.0_s_at
A_51_P404204
A_52_P214058
A_52_P412600
X03484
216995_x_at
38743_f_at
38742_s_at
201244_s_at
1557675_at
1917_at
X03484_at
A_23_P40952
A_14_P103765
A_14_P126015
A_14_P115592
R648
OR0812
644
OH7835
M15428complete_seq_at
1389382_at
rc_AI639494_at
rc_AA817992_at
NM_012639
A_65_P02354
H3117E08-3
NM_029780
242425_at
213010_at
I_928612
94265_at
GenBank ID 18497289
18497290
13383316
13383317
13429987
13429988
18157433
18157434
18150195
18150196
12857902
12857903
26085159
15929694
15929695
33991673
34098686
BQ221862
51464027
52486392
4506401
51464120
30016944
30016945
190837
496091
34190937
17390263
35841
35842
125651
66762
NT_039353
NW_043767
NT_039355
NT_005927
51717211
34858854
40254798
6981458
38303884
38303885
206544
206545
206546
206547
125653
AAH18119
AY271661
BC018119
CAA27204
L00212
NC_000003
NM_002880
NP_002871
NT_022517
NT_086636
P04049
X03484
AAA42001
AAA42002
AAH62071
BC062071
M15427
M15428
NC_005103
NM_012639
NP_036771
NW_047696
P11345
AAP03432
AAH15273
AAH92040
AB052739
AB057655
AB057663
AB077145
AK018272
AK036317
AK141745
AK142706
AK148327
AK189599
AK190457
AK191593
AK193894
AK199760
AK215463
BAB31142
BAB39527
BAB39743
BAB39748
BAB83675
BAE24820
BC015273
BC056439
BC092040
NC_000072
NM_029780
NP_084056
NT_094510
Q99N57
X55432
AAA60247
Chromosome position 4q42
6 52.5 cM
3p25
GO ID 0006915
0007242
0004709
0005626
0007507
0000166
0004674
0004713
0005057
0000074
0004672
0005622
0005829
0005886
0007165
0007243
0016301
0050875
0005515
0005524
0005741
0006468
GO:0004709
GO:0004713
GO:0005524
GO:0004674
GO:0005515
GO:0005057
GO:0004672
GO:0016301
GO:0016740
GO:0019992
GO:0007507
GO:0007243
GO:0008151
GO:0006468
GO:0007242
GO:0007165
GO:0000074
GO:0005626
GO:0005829
GO:0005622
GO:0005886
GO:0006915
GO:0008283
GO:0005741
GO:0007048
0008283
0016740
0019992
0046872
Alias murine sarcoma 3611 oncogene 1
protein kinase raf-1
raf proto-oncogene serine/threonine protein kinase
sarcoma 3611 oncogene
v-raf-1 leukemia viral oncogene 1
v-raf-1 murine leukemia viral oncogene homolog 1
6430402F14Rik
AA990557
C-RAF
KRAF
Raf kinase
KRAF_HUMAN
murine sarcoma 3611 oncogene I
v-raf-1 leukemia viral oncogene I
Raf I
protein kinase raf I
cRaf
Oncogene RAF1
v-Raf
v-raf-1 murine leukemia viral oncogene homolog I
Oncogene RAF I
c-Raf-1
raf oncogene
RAS-GTP binding protein kinase
c-Raf-1 s
Raf
RAF-1
Raf1
cRaf-1
cRaf1
murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
Craf1 transforming gene
protein kinase raf 1
D830050J10Rik
MIL
RAF1_HUMAN
(RAF1)
(RAF)
RAS-GTP
Organism Mus musculus
Rattus norvegicus
Homo sapiens
Human
MedLine Reference 10329666
14636584
9488663
10433554
8063729
8929532
9779826
LocusLink ID 106517
104335
24703
101411
19372
76876
110157
12906
5894
FunctionalClass kinase
MAP kinase kinase kinase
ATP binding
diacylglycerol binding
metal ion binding
nucleotide binding
protein binding
protein serine/threonine kinase
protein-tyrosine kinase
receptor signaling protein
transferase
protein kinase
RGD ID 3531
Hugo Symbol RAF1
Unigene ID Rn.33262
Mm.184163
Hs.159130
Hs.257266
Rn.5936
Mm.252688
Mm.22467
Hs.349650
KEGG pathway Focal adhesion
MAPK signaling pathway
Regulation of actin cytoskeleton
Keyword plasma membrane
PKC
protein serine/threonine kinase
RAS small monomeric GTPase
MAP kinase
map kinase kinase
activated blood coagulation factor XIV
oncogene
GEF
sh-2 domain
14-3-3
growth factor
mitochondrial membrane
map kinases
protein serine/threonine kinase activity
GO Cellular Component mitochondrial outer membrane
cytosol
intracellular
plasma membrane
insoluble fraction
GO Molecular Function MAP kinase kinase kinase activity
protein-tyrosine kinase activity
ATP binding
protein serine/threonine kinase activity
protein binding
receptor signaling protein activity
protein kinase activity
kinase activity
transferase activity
diacylglycerol binding
ATP binding activity
protein binding activity
protein tyrosine kinase activity
diacylglycerol binding activity
Cell Localization Cytoplasm
Mitochondria
Pathway p40 MAPK
PDGF signaling
Insulin pathway
IL-6 signaling
IL-3 signaling
IL-2 signaling
IL-1 and IL-6 signaling
Erythropoietin signaling
Erk-PI3K in Collagen Binding
EGF signaling
Antiapoptotic Pathways From IGF-1R
MAPK-ERK in Growth and Differentiation
Jak-Stat Pathway from IL6 Receptor
Insulin Receptor Signaling
Integrin Signaling
G-protein Coupled Receptor signaling
Apoptosis
Mitochondrial control of Apoptosis
Inhibition of Apoptosis
NGF signaling
CD40L
ACVR1B -> JUNB signalling pathway
ACVR1B -> MADH7 signalling pathway
ACVRL1 -> STAT1 signalling pathway
ACVRL1 -> MADH1 signalling pathway
ACVRL1 -> MADH2 signalling pathway
NCAM1 -> TP53 signalling pathway
NCAM1 -> FOS signalling pathway
NCAM1 -> CREB1 signalling pathway
TNFRSF11A -> JUN signalling pathway
TNFRSF10B -> REL signalling pathway
NGFR -> RUNX1 signalling pathway
NGFR -> FOS signalling pathway
NGFR -> PAX6 signalling pathway
NGFR -> CEBPB signalling pathway
NGFR -> CREB1 signalling pathway
NOTCH1 -> FOS signalling pathway
NOTCH1 -> MEF2C signalling pathway
NPHS1 -> JUN signalling pathway
NTRK1 -> MYC signalling pathway
NTRK1 -> RUNX1 signalling pathway
NTRK1 -> FOS signalling pathway
NTRK1 -> CREB1 signalling pathway
NTRK1 -> MADH3 signalling pathway
NTRK2 -> JUN signalling pathway
NTRK2 -> CREB1 signalling pathway
OPRM1 -> JUNB signalling pathway
OPRM1 -> FOS signalling pathway
TEK -> CEBPB signalling pathway
TGFBR1 -> SP1 signalling pathway
TGFBR1 -> MADH4 signalling pathway
TLR4 -> CEBPA signalling pathway
TLR4 -> EGR1 signalling pathway
TNFRSF1A -> FOS signalling pathway
TNFRSF1A -> CREB1 signalling pathway
TNFRSF1A -> RELA signalling pathway
TNFRSF1B -> STAT1 signalling pathway
TNFRSF1B -> CREB1 signalling pathway
TRIO -> SRF signalling pathway
ADORA1 -> FOS signalling pathway
ADRA1B -> SRF signalling pathway
ADRB1 -> MYC signalling pathway
ADRB2 -> CREB1 signalling pathway
AGER -> MYOG signalling pathway
AGER -> HMG1 signalling pathway
AGTR1 -> MYC signalling pathway
AGTR1 -> TP53 signalling pathway
AGTR1 -> FOS signalling pathway
AGTR1 -> STAT1 signalling pathway
AGTR1 -> CREB1 signalling pathway
AGTR1 -> MADH2 signalling pathway
AGTR2 -> MYC signalling pathway
AGTR2 -> TP53 signalling pathway
AGTR2 -> JUN signalling pathway
AGTR2 -> FOS signalling pathway
AGTR2 -> PAX2 signalling pathway
AGTR2 -> CREB1 signalling pathway
VCAM1 -> RELA signalling pathway
HTR2A -> FOS signalling pathway
VIPR1 -> CREB1 signalling pathway
ICAM1 -> TFAP2A signalling pathway
ICAM1 -> ETS1 signalling pathway
ICAM1 -> FOS signalling pathway
ICAM1 -> CREB1 signalling pathway
TNFRSF6 -> MYC signalling pathway
TNFRSF6 -> HIF1A signalling pathway
TNFRSF6 -> BCL6 signalling pathway
TNFRSF6 -> FOS signalling pathway
TNFRSF6 -> SP1 signalling pathway
TNFRSF6 -> SREBF1 signalling pathway
TNFRSF6 -> SRF signalling pathway
TNFRSF6 -> ATF2 signalling pathway
TNFRSF6 -> DDIT3 signalling pathway
TNFRSF6 -> E2F1 signalling pathway
TNFRSF6 -> RELA signalling pathway
IFNAR1 -> CDX2 signalling pathway
IGF1R -> RUNX2 signalling pathway
IGF1R -> FOS signalling pathway
IGF1R -> SREBF1 signalling pathway
IGF1R -> CEBPA signalling pathway
IGF1R -> EGR1 signalling pathway
IL1R1 -> FOS signalling pathway
IL2RB -> MYC signalling pathway
IL2RB -> JUN signalling pathway
IL2RB -> FOS signalling pathway
IL4R -> MYC signalling pathway
IL4R -> GATA3 signalling pathway
IL6R -> JUNB signalling pathway
IL6R -> CEBPA signalling pathway
IL6R -> MITF signalling pathway
IL6ST -> MYC signalling pathway
IL6ST -> JUN signalling pathway
IL6ST -> CEBPA signalling pathway
IL6ST -> CEBPB signalling pathway
IL7R -> TCF1 signalling pathway
IL7R -> TCF3 signalling pathway
KLRG1 -> MYC signalling pathway
KLRG1 -> TP53 signalling pathway
KLRG1 -> IPF1 signalling pathway
KLRG1 -> FOS signalling pathway
KLRG1 -> PAX6 signalling pathway
ITGA2B -> BCL3 signalling pathway
ITGAM -> JUN signalling pathway
ITGAM -> SPI1 signalling pathway
ITGAM -> CEBPB signalling pathway
ITGAM -> RELA signalling pathway
ITGB1 -> MYC signalling pathway
ITGB1 -> SREBF1 signalling pathway
ITGB1 -> CTNNB1 signalling pathway
ITGB2 -> CEBPB signalling pathway
KDR -> HIF1A signalling pathway
KDR -> HSPCA signalling pathway
KDR -> ATF1 signalling pathway
KDR -> ETS1 signalling pathway
KDR -> TAL1 signalling pathway
KDR -> CREB1 signalling pathway
KDR -> EGR3 signalling pathway
KIT -> TP53 signalling pathway
KIT -> HSPCA signalling pathway
KIT -> FOS signalling pathway
KIT -> TAL1 signalling pathway
KIT -> MITF signalling pathway
SEMA6B -> FOS signalling pathway
CCKAR -> FOS signalling pathway
CCKBR -> FOS signalling pathway
CCKBR -> EGR1 signalling pathway
LDLR -> SREBF1 signalling pathway
LDLR -> CTNNB1 signalling pathway
LEPR -> CEBPB signalling pathway
CD2 -> MYC signalling pathway
CD2 -> IRF1 signalling pathway
CD2 -> GATA3 signalling pathway
CD4 -> GATA3 signalling pathway
CD4 -> STAT1 signalling pathway
CD4 -> STAT6 signalling pathway
CD19 -> JUND signalling pathway
CD19 -> FOS signalling pathway
CD28 -> BCL6 signalling pathway
CD28 -> FOS signalling pathway
CD28 -> TCF3 signalling pathway
CD28 -> ATF2 signalling pathway
CD28 -> CREBBP signalling pathway
CD28 -> RELA signalling pathway
CD28 -> EGR2 signalling pathway
CD38 -> TCF3 signalling pathway
TNFRSF5 -> MYC signalling pathway
TNFRSF5 -> JUNB signalling pathway
TNFRSF5 -> JUND signalling pathway
TNFRSF5 -> FOS signalling pathway
TNFRSF5 -> TCF3 signalling pathway
TNFRSF5 -> CREB1 signalling pathway
KLRA1 -> TCF1 signalling pathway
EPHA1 -> JUN signalling pathway
EPHA3 -> TP53 signalling pathway
EPHA3 -> TCF3 signalling pathway
EPHA3 -> CTNNB1 signalling pathway
EPHA4 -> JUN signalling pathway
EPOR -> MYC signalling pathway
EPOR -> FOS signalling pathway
EPOR -> SPI1 signalling pathway
ERBB2 -> TP53 signalling pathway
ERBB2 -> HSPCA signalling pathway
ERBB3 -> MYOG signalling pathway
F2R -> HSPCA signalling pathway
F2R -> SP1 signalling pathway
F2R -> SRF signalling pathway
F2R -> CEBPB signalling pathway
F2R -> CREB1 signalling pathway
EDAR -> CTNNB1 signalling pathway
EDAR -> EGR1 signalling pathway
FCGR2B -> GATA4 signalling pathway
FCGR3A -> MYC signalling pathway
FCGR3A -> FOS signalling pathway
FGFR1 -> JUN signalling pathway
FGFR1 -> CREB1 signalling pathway
FGFR3 -> SOX9 signalling pathway
FGFR2 -> FOS signalling pathway
FGFR2 -> SOX9 signalling pathway
FLT1 -> NFATC1 signalling pathway
FLT1 -> HIF1A signalling pathway
FLT1 -> FOS signalling pathway
FLT1 -> CREB1 signalling pathway
FLT3 -> HSPCA signalling pathway
FLT3 -> CEBPA signalling pathway
SELE -> FOS signalling pathway
CD244 -> EGR3 signalling pathway
FSHR -> FOS signalling pathway
SPN -> MYC signalling pathway
SPN -> TP53 signalling pathway
SPN -> TCF3 signalling pathway
GHR -> MYC signalling pathway
GHR -> FOS signalling pathway
GHR -> SPI1 signalling pathway
GHR -> EGR1 signalling pathway
SSTR1 -> FOS signalling pathway
SSTR2 -> TP53 signalling pathway
SSTR2 -> JUN signalling pathway
SSTR2 -> ATF2 signalling pathway
GNRHR -> FOS signalling pathway
GNRHR -> EGR1 signalling pathway
GPR9 -> CDX2 signalling pathway
GPR9 -> RELA signalling pathway
GRIA2 -> FOS signalling pathway
GRIA3 -> FOS signalling pathway
GRIN1 -> FOS signalling pathway
GRIN1 -> CREB1 signalling pathway
GRM1 -> CREB1 signalling pathway
GRM2 -> FOS signalling pathway
GRM5 -> FOS signalling pathway
GRM5 -> CREB1 signalling pathway
GRM5 -> EGR1 signalling pathway
PDGFRB -> FOS signalling pathway
PECAM1 -> SP1 signalling pathway
PECAM1 -> RBL2 signalling pathway
EDG5 -> FOS signalling pathway
CHRNA7 -> CREB1 signalling pathway
CCR4 -> CNOT4 signalling pathway
CCR5 -> TP53 signalling pathway
CNR1 -> EGR1 signalling pathway
CNR2 -> EGR1 signalling pathway
PLAUR -> FOS signalling pathway
PLAUR -> SP1 signalling pathway
CSF1R -> JUN signalling pathway
CSF1R -> FOS signalling pathway
CSF3R -> MYC signalling pathway
CSF3R -> SPI1 signalling pathway
TAS2R13 -> ATF4 signalling pathway
PTGDR -> EGR1 signalling pathway
PTPRA -> TEAD1 signalling pathway
PTPRC -> NFATC2 signalling pathway
PTPRE -> MYC signalling pathway
PTPRE -> EGR1 signalling pathway
PTPRJ -> FOS signalling pathway
DRD1 -> CTNNB1 signalling pathway
DRD2 -> JUN signalling pathway
DRD2 -> FOS signalling pathway
DRD2 -> CREB1 signalling pathway
DRD2 -> EGR1 signalling pathway
DRD3 -> FOS signalling pathway
RET -> HSF1 signalling pathway
RET -> JUN signalling pathway
RET -> JUND signalling pathway
RET -> CREB1 signalling pathway
EDNRB -> FOS signalling pathway
EGFR -> MYC signalling pathway
EGFR -> HSPCA signalling pathway
EGFR -> JUN signalling pathway
EGFR -> FOS signalling pathway
EGFR -> CREB1 signalling pathway
MC1R -> MADH4 signalling pathway
MC1R -> MADH6 signalling pathway
MC1R -> MITF signalling pathway
MET -> TP53 signalling pathway
MET -> JUN signalling pathway
MET -> ETS1 signalling pathway
MET -> FOS signalling pathway
MET -> TAL1 signalling pathway
MET -> CTNNB1 signalling pathway
MET -> EGR1 signalling pathway
MET -> MADH2 signalling pathway
MET -> MAX signalling pathway
MPL -> CEBPA signalling pathway
AGT-LRP2
CCL19-IL2RB
CCL4-CD4
CCL4-TNFRSF8
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF2-CSF2RA
CSF3-CSF3R
CSF3-IL6R
DTR-CD44
DTR-EGFR
DTR-ERBB4
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
EPO-EPOR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF1-FGFR1
FGF1-FGFR2
FGF1-FGFR3
FGF1-GPC1
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
GH1-PRLR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IFNB1-IFNAR1
IFNB1-IFNAR2
IFNG-HLA-C
IFNG-IFNGR1
IFNG-IFNGR2
IGF1-BST1
IGF1-IGF1R
IGF1-IGF2R
IGF1-LRP5
IL10-IL10RA
IL10-TNFRSF7
IL11-IL6R
IL11-IL6ST
IL15-IL15RA
IL15-IL2RB
IL15-IL2RG
IL17-IL17R
IL1A-IL1R1
IL1A-IL1RAP
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL4-FCER2
IL4-IL2RG
IL4-IL4R
IL5-IL5RA
IL5-IL6ST
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL7-IL2RG
IL7-IL7R
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NRG1-CD44
NRG1-EGFR
NRG1-ERBB2
NRG1-ERBB3
NRG1-ERBB4
OSM-CD22
OSM-IL6ST
OSM-LIFR
PF4-THBD
PGF-FLT1
PGF-KDR
PRL-PRLR
PTH-IL6ST
SDF1-CD4
SDF1-IL6ST
SPP1-CD44
SPP1-ITGAV
TAC1-TNFRSF11B
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THPO-EPOR
THPO-MPL
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1A
TNF-TNFRSF1B
TNF-TNFRSF6
TNFSF5-CD28
TNFSF5-CD80
TNFSF5-TNFRSF5
TNFSF5-TNFRSF6
TNFSF5-TNFRSF7
TNFSF5-TNFRSF8
TNFSF6-TNFRSF6
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
CB0479 MAPK
CB0480 Insulin
Compartment plasma membrane
mitochondrial membrane
GO Biological Process cellular physiological process
protein kinase cascade
regulation of progression through cell cycle
signal transduction
heart development
apoptosis
cell proliferation
intracellular signaling cascade
protein amino acid phosphorylation
regulation of cell cycle
cell growth and/or maintenance
oncogenesis
Group Kinases
EC Number 2.7.1.37
2.7.1.-
State p
MGI ID 97847
Swiss-Prot Accession P04049
OMIM ID 164760
OMIM:164760
Source Curated
BIND
ResNet
 
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