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Insulin Pathway: SHIP
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| PhosphoDetect™ Anti-SHIP1 (pTyr1020) Rabbit pAb |
IB |
human, mouse |
ST1081 |
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| | | | Additional Information | | | | | | | | |
| Protein : SHIP (INPPL1)
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| Name | SHIP (INPPL1) |
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| Description | inositol polyphosphate phosphatase-like 1 |
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| Owner | Public |
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| URN | urn:agi-llid:3636 |
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| Connectivity | 30 |
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| Notes | INPPL1 encodes inositol polyphosphate-5 phosphatase-like 1, a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif. A novel regulatory role is suggested for SHIP2 in macrophage colony-stimulating factor (M-CSF)-stimulated myeloid cells. Findings suggest that SHIP2 gene expression is controlled by the Sp-family of transcription factors. INPPL1 variants may impact susceptibility to disease and/or to subphenotypes involved in the metabolic syndrome in some diabetic patients. SHIP phosphorylation by the immunoreceptor tyrosine-based activation motif (ITAM)-associated Fc gamma RIIa requires Shc phosphorylation, leads to activation of Src kinases, and down-regulates NF-kappa B-induced gene transcription during phagocytosis. SHIP-2 accumulates transiently at actin-rich regions along the cellular leading edge in HGF-stimulated MDCK cells; overexpression alters HGF-mediated lamellipodium formation. SHIP1 and SHIP2 interact preferentially with Tec and inactivate it by de-phosphorylation of local PtdIns 3,4,5-P(3) and inhibition of Tec membrane localization. SHIP2 plays a distinct role in signaling pathways mediated by integrins and growth factor receptors. Schizosaccharomyces pombe synaptojanin (SPsynaptojanin) and human SH2 domain-containing inositol-5-phosphatase SHIP2 comparison: substrate specificity and mechanism study. Candidate gene for type 2 diabetes. Overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line. Regulation of FcgammaR-mediated activation of human myeloid cells by the expression and function of the inositol phosphatase SHIP-2. |
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| Hugo ID | 6080 |
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| Microarray ID | A_43_P12347 |
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| | A_51_P142334 |
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| | L24444 |
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| | 36598_s_at |
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| | 80433_s_at |
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| | 201598_s_at |
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| | 214609_at |
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| | L36818_at |
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| | A_23_P36314 |
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| | A_14_P132198 |
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| | A_14_P124322 |
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| | A_23_P36322 |
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| | CA118 |
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| | OH1805A |
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| | OR1730A |
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| | 1368022_at |
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| | 1370651_a_at |
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| | rc_ai169506_at |
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| Chromosome position | 11q23 |
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| | 1q32 |
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| GO ID | 0004445 |
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| | 0006796 |
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| | 0004437 |
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| | 0007242 |
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| Alias | 51(C) |
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| | 51C |
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| | 51-C |
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| | INPPL Is |
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| | INPPL1s |
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| | inositol polyphosphate phosphatase-like 1 |
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| | INPPL1 |
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| | SHIP2 |
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| | inositol polyphosphate phosphatase-like I |
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| | SH2-containing inositol phosphatase II |
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| | SH2-containing inositol phosphatase 2 |
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| | INPPL I |
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| Organism | Mus musculus |
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| | Homo sapiens |
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| | Rattus norvegicus |
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| FunctionalClass | inositol-polyphosphate 5-phosphatase |
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| | inositol or phosphatidylinositol phosphatase |
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| Cell Localization | Cytoplasm |
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| Pathway | DTR-EGFR |
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| | GRO1-EGFR |
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| | IGF1-BST1 |
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| | IGF1-IGF2R |
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| | IGF1-LRP5 |
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| | INS-EGFR |
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| | INS-HLA-DRB1 |
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| | INS-TFRC |
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| | VEGF-EGFR |
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| | CB0480 Insulin |
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| | simple mTOR |
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| GO Biological Process | intracellular signaling cascade |
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| | phosphate metabolism |
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