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		Interactive Pathways

		Protein Tyrosine Kinase

		Insulin

Insulin Pathway: SOS

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For additional information on this protein, please refer to the general information provided below.

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Protein : SOS1


Name	SOS1
Description	Son of Sevenless homolog 1. mSos1 is a Ras guanine nucleotide exchange factor with a DH and a PH domain.
Owner	Public
URN	urn:agi-llid:6654
Connectivity	119
Notes	RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]
Hugo ID	11187


Microarray ID	1421884_at
	100940_at
	1421885_at
	1421886_at
	160911_at
	229261_at
	230337_at
	N25110_at
	85839_at
	A_23_P343808
	A_14_P137836
	A_14_P135781
	A_14_P124985
	A_14_P128988
	E111
	OH3321
	OH8371
	1557354_at
	z11574_s_at
	A_51_P125786
	A_51_P125792
	212777_at
	212780_at
	33260_at
	227426_at


GenBank ID	AC019171
	AC092672
	AF106953
	AF441482
	BAD92377
	L13857
	NC_000002
	NM_005633
	NP_005624
	NT_022184
	NT_086610
	Q07889
	34862075
	34862057
	34862058
	51770478
	6678062
	6678063
	54134
	54135
	54132
	54133
	6175037
	51460714
	15529995
	15529996
	51461052
	7160780
	6164601
	20467101
	20467105
	306777
	306778
	6094322
	AF094676
	AF233591
	AK140310
	BAE24327
	CAA77662
	CAA77665
	NC_000083
	NM_009231
	NP_033257
	NT_039658
	Q62245
	Z11574
	Z11578
	AF094677
	AF094679
	AAF08009
	AAF42937
	AF094674
	AF094675
	AAI00643
	BC100642
	NC_005105
	NW_047754
	XM_233820
	XP_233820
	AAA35913
	AAF04460
	AAM22406
	AAX93186
	AAY24202
	AB209140


Chromosome position	6q11
	2p22-p21
	17 44.0 cM


GO ID	0005085
	0005515
	0007242
	0007264
	0003677
	0005088
	0005089
	0005100
	0007265


Alias	similar to Son of sevenless protein homolog 1 (SOS-1) (mSOS-1)
	gingival fibromatosis, hereditary
	SOS
	Son of sevenless homolog 1, (Drosophila)
	Sos1_predicted
	HGNC:4269
	alternate sos1
	ras guanine exchange factor
	son of sevenless (Drosophila) homolog I
	mSos
	hSos
	hSos1
	rSos
	rSos1
	Son of sevenless
	gingival fibromatosis
	mSos1
	GGF1
	GINGF
	gingival fibromatosis, hereditary, 1
	Son of sevenless 1
	son of sevenless homolog 1
	Sos1
	Son of sevenless protein homolog 1 (SOS-1) (mSOS-1)
	son of sevenless (Drosophila) homolog 1
	gingival fibromatosis, hereditary, I
	son of sevenless homolog I
	son of sevenless homolog 1 (Drosophila)
	Son of sevenless I
	GGF I
	Sos I


Organism	Human
	Homo sapiens
	Mus musculus
	Rattus norvegicus


MedLine Reference	9182757
	8493579
	9790532


LocusLink ID	6654
	20662
	56665
	7838
	313845
	85384


FunctionalClass	guanyl-nucleotide exchange factor
	protein binding
	DNA binding
	Ras guanyl-nucleotide exchange factor
	Rho GTPase activator
	Rho guanyl-nucleotide exchange factor


RGD ID	1310949
	620435


Hugo Symbol	SOS1


Unigene ID	Rn.91844
	Mm.60975
	Hs.278733
	Rn.4226
	Hs.326392


Cell Localization	Nucleus
	Cytoplasm


Pathway	p40 MAPK
	Insulin pathway
	CREB signaling
	Antiapoptotic Pathways From IGF-1R
	MAPK-ERK in Growth and Differentiation
	PTEN signaling
	Insulin Receptor Signaling
	Integrin Signaling
	G-protein Coupled Receptor signaling
	NGF signaling
	TNF-alpha
	RANKL
	LT-alpha
	HGF
	EPHA2
	OPRM1 -> JUNB signalling pathway
	VIPR1 -> IRF1 signalling pathway
	EPOR -> MYC signalling pathway
	FCGR2B -> GATA4 signalling pathway
	FLT3 -> HSPCA signalling pathway
	PTPRE -> EGR1 signalling pathway
	AREG-EGFR
	BTC-EGFR
	CSF1-TNFRSF5
	DTR-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	EREG-EGFR
	FGF1-FGFR1
	FGF1-FGFR2
	FGF1-FGFR3
	FGF1-GPC1
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	GDNF-RET
	GRO1-EGFR
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NRG1-EGFR
	NUDT6-FGFR1
	TGFA-EGFR
	TGFB1-SELL
	VEGF-EGFR
	VEGFC-FLT1
	CB0479 MAPK
	CB0480 Insulin


GO Biological Process	Ras protein signal transduction
	intracellular signaling cascade
	small GTPase mediated signal transduction


Group	Gtpase regulators
	Ph


MGI ID	98354


Swiss-Prot Accession	Q07889


OMIM ID	182530
	135300
	OMIM:182530
	OMIM:135300


Source	BIND
	Curated