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Insulin Pathway: TNF
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| Anti-TNF-a (Ab-1) Mouse mAb (1825.121) |
ELISA, IB, NT |
human |
GF31 |
| Anti-TNF-a Rabbit pAb |
ELISA, FS, IB, NT, PS, RIA |
human, mouse (weakly) |
654250 |
| Anti-TNF-a Rabbit pAb |
ELISA, IB, NT |
mouse, rat |
654300 |
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| | | Inhibitors
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| TNF-a Antagonist |
654255 |
| TNF-a Antagonist III, R-7050 NEW! |
654257 |
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| | | Proteins/Enzymes
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| TNF-a, Human, Recombinant, E. coli |
654205 |
| TNF-a, Mouse, Recombinant, E. coli |
654245 |
| TNF-b, Human, Recombinant, E. coli |
654215 |
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| | | | Additional Information | | | | | | | | |
| Protein : TNF
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| Name | TNF |
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| Description | tumor necrosis factor (TNF superfamily, member 2) |
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| Owner | Public |
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| URN | urn:agi-llid:7124 |
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| Connectivity | 342 |
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| Notes | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
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| Hugo ID | 11892 |
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| Microarray ID | NM_012675 |
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| | 102630_s_at |
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| | Msa.256.0_at |
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| | NM_013693.1 |
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| | NM_013693 |
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| | NM_000594.2 |
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| | I_3328355 |
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| | I_1109711 |
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| | 1387691_at |
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| | e02468cds_s_at |
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| | A_43_P11513 |
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| | 102629_at |
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| | 1419607_at |
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| | tnfa_at |
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| | x02611_s_at |
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| | A_65_P16584 |
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| | A_51_P385099 |
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| | X01394 |
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| | 207113_s_at |
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| | 1852_at |
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| | 259_s_at |
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| | X02910_at |
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| | A_32_P458667 |
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| | A_23_P168071 |
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| | A_23_P376488 |
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| | A_14_P109737 |
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| | A_14_P125975 |
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| | A_14_P110091 |
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| | A_24_P50759 |
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| | R579 |
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| | OR0747 |
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| | 23 |
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| | OH7652 |
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| | RA0508 |
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| | OR3746 |
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| Chromosome position | 6p21.3 |
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| | 20p12 |
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| | 17 19.06 cM |
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| | |
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| GO ID | 0007515 |
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| | 0019221 |
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| | 0045672 |
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| | 0050875 |
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| | GO:0016020 |
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| | GO:0016021 |
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| | GO:0005887 |
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| | GO:0005886 |
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| | GO:0030141 |
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| | GO:0045672 |
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| | GO:0009615 |
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| | GO:0006916 |
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| | GO:0008220 |
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| | GO:0007159 |
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| | GO:0006355 |
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| | GO:0007267 |
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| | GO:0005625 |
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| | GO:0006960 |
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| | GO:0006889 |
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| | GO:0005164 |
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| | GO:0005125 |
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| | GO:0007515 |
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| | GO:0006927 |
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| | GO:0008151 |
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| | GO:0008284 |
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| | GO:0006959 |
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| | GO:0006952 |
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| | GO:0006968 |
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| | GO:0007275 |
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| | GO:0006915 |
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| | GO:0006955 |
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| | GO:0008283 |
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| | GO:0007165 |
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| | GO:0006954 |
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| | GO:0009887 |
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| | GO:0042127 |
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| | GO:0045670 |
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| | GO:0045123 |
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| | 0008625 |
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| | 0005164 |
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| | 0005615 |
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| | 0005625 |
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| | 0006355 |
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| | 0006915 |
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| | 0006916 |
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| | 0006954 |
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| | 0007159 |
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| | 0007165 |
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| | 0007267 |
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| | 0008219 |
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| | 0009615 |
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| | 0016020 |
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| | 0016021 |
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| | 0009887 |
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| | 0001932 |
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| | 0005125 |
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| | 0005886 |
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| | 0005887 |
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| | 0006006 |
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| | 0006927 |
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| | 0006952 |
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| | 0006955 |
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| | 0006959 |
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| | 0006968 |
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| | 0007275 |
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| | 0008283 |
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| | 0008284 |
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| | 0030141 |
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| | 0030316 |
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| | 0042127 |
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| | 0042742 |
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| | 0043123 |
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| | 0045123 |
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| | 0045670 |
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| | 0046325 |
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| | 0048535 |
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| | 0051023 |
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| | 0004871 |
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| | 0006917 |
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| Alias | Tnf |
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| | superfamily, member 2 |
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| | DIF |
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| | tumor necrosis factor superfamily, member 2 |
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| | Tumor necrosis factor alpha (cachetin) |
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| | tumor necrosis factor superfamily member 2 |
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| | tumor necrosis factor superfamily, member 2 |
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| | TNF alpha |
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| | tumor necrosis factor-alpha |
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| | TNFalpha |
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| | tumor necrosis factor alpha |
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| | tumor necrosis factor alpha precursor |
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| | Cachectin |
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| | TNF superfamily, member 2 |
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| | TNF, monocyte-derived |
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| | TNFA |
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| | TNF-alpha |
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| | TNFSF2 |
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| | tumor necrosis factor (TNF superfamily, member 2) |
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| | tumor necrosis factor 2 |
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| | tumor necrosis factor, alpha (cachectin) |
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| | tumour necrosis factor alpha |
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| | TNFA_HUMAN |
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| | RATTNF |
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| | TNF, macrophage-derived |
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| | tumor necrosis factor, alpha (cachetin) |
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| | TNF superfamily, member II |
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| | tumor necrosis factor II |
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| | tumor necrotizing factor alpha |
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| | TNFSF2s |
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| | tumor necrosis factor, alpha |
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| | Tnfsf1a |
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| | APC1 protein |
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| | APC1 gene |
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| Organism | Homo sapiens |
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| | Mus musculus |
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| | Rattus norvegicus |
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| | Human |
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| FunctionalClass | tumor necrosis factor receptor binding |
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| | cytokine |
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| | signal transducer |
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| KEGG pathway | Apoptosis |
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| | Cytokine-cytokine receptor interaction |
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| | MAPK signaling pathway |
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| | TGF-beta signaling pathway |
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| | Toll-like receptor signaling pathway |
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| Keyword | desmoplakin |
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| | death receptor |
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| | tumor necrosis factor |
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| | thrombin |
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| | activated blood coagulation factor XIV |
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| | LDL |
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| | RAS small monomeric GTPase |
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| | endotoxin |
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| | dechlorinase |
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| | receptor |
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| | growth factor |
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| | desmoplakins |
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| | receptor activity |
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| | endothelium-derived relaxation factor-forming enzyme |
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| | RNA |
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| | nuclei |
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| | DNA |
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| | 1.14.13.39 |
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| | cytokine activity |
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| | nucleus |
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| GO Cellular Component | extracellular space |
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| | integral to membrane |
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| | membrane |
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| | soluble fraction |
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| | integral to plasma membrane |
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| | plasma membrane |
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| | secretory granule |
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| GO Molecular Function | tumor necrosis factor receptor binding |
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| | cytokine activity |
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| | tumor necrosis factor receptor ligand activity |
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| Cell Localization | Extracellular |
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| Pathway | Death receptor signaling |
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| | Apoptosis |
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| | Inhibition of Apoptosis |
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| | NF-kB Signaling |
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| | TNF-alpha signaling |
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| | TNFR1 signaling |
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| | TNF-alpha |
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| | DR6 |
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| | TNFRSF1A -> ZFP36 signalling pathway |
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| | TNFRSF1A -> JUN signalling pathway |
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| | TNFRSF1A -> FOS signalling pathway |
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| | TNFRSF1A -> STAT1 signalling pathway |
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| | TNFRSF1A -> STAT3 signalling pathway |
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| | TNFRSF1A -> CREB1 signalling pathway |
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| | TNFRSF1A -> ATF2 signalling pathway |
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| | TNFRSF1A -> REL signalling pathway |
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| | TNFRSF1A -> RELA signalling pathway |
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| | TNFRSF1B -> JUN signalling pathway |
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| | TNFRSF1B -> STAT1 signalling pathway |
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| | TNFRSF1B -> LRRFIP1 signalling pathway |
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| | TNFRSF1B -> CREB1 signalling pathway |
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| | TNF-IL15RA |
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| | TNF-NGFR |
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| | TNF-TNFRSF1A |
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| | TNF-TNFRSF1B |
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| | TNF-TNFRSF6 |
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| GO Biological Process | anti-apoptosis |
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| | apoptosis |
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| | cell death |
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| | cell-cell signaling |
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| | inflammatory response |
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| | leukocyte adhesion |
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| | regulation of transcription, DNA-dependent |
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| | response to virus |
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| | signal transduction |
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| | cell proliferation |
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| | cellular defense response |
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| | cellular extravasation |
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| | defense response |
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| | defense response to bacteria |
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| | development |
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| | glucose metabolism |
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| | humoral immune response |
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| | immune response |
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| | induction of apoptosis via death domain receptors |
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| | lymph node development |
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| | negative regulation of glucose import |
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| | organogenesis |
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| | osteoclast differentiation |
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| | positive regulation of I-kappaB kinase/NF-kappaB cascade |
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| | positive regulation of cell proliferation |
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| | programmed cell death, transformed cells |
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| | regulation of cell proliferation |
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| | regulation of immunoglobulin secretion |
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| | regulation of osteoclast differentiation |
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| | regulation of protein amino acid phosphorylation |
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| | cellular physiological process |
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| | cytokine and chemokine mediated signaling pathway |
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| | induction of apoptosis |
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| | lymph gland development |
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| | positive regulation of osteoclast differentiation |
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| | leukocyte cell adhesion |
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| | cell growth and/or maintenance |
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| | necrosis |
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| | regulation of calcium in ER |
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| | killing transformed cells |
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| | antimicrobial humoral response (sensu Invertebrata) |
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| | response to viruses |
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| Source | Curated |
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| | BIND |
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| | ResNet |
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