Insulin Pathway: mTOR

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mTOR Antibodies

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mTOR Assay Kits

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mTOR Inhibitor

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Protein : mTOR (FRAP1)


Name	mTOR (FRAP1)
Description	FK506 binding protein 12-rapamycin associated protein 1
Owner	Public
URN	urn:agi-llid:2475
Connectivity	159
Notes	The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.
Hugo ID	3942


Alias	AI327068
	FK506 binding protein 12-rapamycin associated protein 1
	FK506 binding protein 12-rapamycin associated protein 2
	FKBP-rapamycin associated protein
	RAFT1
	rapamycin target protein
	RAPT1
	FRAP_HUMAN
	Frap I
	RAFT I
	RAPT I
	2610315D21Rik
	FRAP2
	FKBP12-rapamycin complex-associated protein I
	FK506 binding protein 12-rapamycin associated protein II
	Frap1
	MTOR
	FKBP-rapamycin-associated protein FRAP
	FRAP
	FKBP-rapamycin-associated protein
	FKBP-rapamycin-associated protein (FRAP)
	rapamycin and FKBP12 target-1 protein
	FKBP12-rapamycin complex-associated protein 1
	Target of rapamycin
	rapamycin associated protein frap2
	dj576k7.1 (fk506 binding protein 12-rapamycin associated protein 1)
	angiopoietin-like factor cdt6
	dj576k7.1
	flat-top protein


FunctionalClass	drug binding
	protein binding
	inositol or phosphatidylinositol kinase
	binding
	kinase
	phosphoprotein binding
	phosphotransferase activity, alcohol group as acceptor
	transferase
	protein serine/threonine kinase


RGD ID	68371


Hugo Symbol	FRAP1


GO Cellular Component	cytoplasm
	membrane
	phosphoinositide 3-kinase complex


Cell Localization	Cytoplasm


Pathway	Jak-Stat Pathway from IL6 Receptor
	Insulin Receptor Signaling
	AGT-LRP2
	BDNF-NCAM1
	BDNF-NGFR
	BDNF-NTRK1
	BDNF-NTRK2
	BDNF-NTRK3
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	FGF9-FGFR3
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL16-CD4
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL7-IL2RG
	IL7-IL7R
	INHBA-ACVR1B
	INHBA-ACVR2
	INHBA-ACVR2B
	INHBA-ACVRL1
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	TNFSF11-TNFRSF11A
	TNFSF11-TNFRSF11B
	CB0480 Insulin
	mTOR
	simple mTOR


GO Biological Process	cell growth
	phosphorylation
	protein catabolism
	regulation of progression through cell cycle
	regulation of translation
	response to nutrients
	signal transduction
	DNA recombination
	DNA repair
	G1/S transition of mitotic cell cycle
	germ cell development
	peptidyl-threonine phosphorylation
	regulation of cell cycle


Group	Kinases


MGI ID	1928394


Swiss-Prot Accession	P42345


Source	Curated

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