 |
|
|
|
|
Insulin Pathway: p70S6K
 | | |  Antibodies
|
|
|
|
|
| Anti-p70S6 Kinase Rabbit pAb |
IB |
human, mouse, rat |
ST1046 |
|
| | | Enzymes
|
|
|
| p70S6K, His•Tag®, Human, Recombinant, S. frugiperda |
506179 |
| p70S6 Kinase, Human, Recombinant, S. frugiperda |
506182 |
|
| | | | Additional Information | | | | | | | | |
| Protein : p70S6K (RPS6KB2)
| | |
|---|
| Name | p70S6K (RPS6KB2) |
|---|
| Description | ribosomal protein S6 kinase, polypeptide 2 |
|---|
| Owner | Public |
|---|
| URN | urn:agi-llid:6199 |
|---|
| Connectivity | 4 |
|---|
| Notes | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date. |
|---|
| Hugo ID | 10437 |
|---|
| | |
|---|
| Microarray ID | 103825_at |
|---|
| | 1422268_a_at |
|---|
| | msa.25087.0_s_at |
|---|
| | A_51_P293553 |
|---|
| | A_52_P182450 |
|---|
| | AB016869 |
|---|
| | 41374_at |
|---|
| | 203777_s_at |
|---|
| | AA410355_at |
|---|
| | rc_aa084901_at |
|---|
| | A_23_P24318 |
|---|
| | A_14_P114204 |
|---|
| | OH3235A |
|---|
| | |
|---|
| Chromosome position | 19 A |
|---|
| | 11q13.2 |
|---|
| | |
|---|
| GO ID | 0004672 |
|---|
| | 0004713 |
|---|
| | 0016301 |
|---|
| | 0000074 |
|---|
| | 0000166 |
|---|
| | 0004674 |
|---|
| | 0005524 |
|---|
| | 0006412 |
|---|
| | 0006468 |
|---|
| | 0007165 |
|---|
| | 0016740 |
|---|
| | |
|---|
| Alias | 70kDa |
|---|
| | ribosomal protein S6 kinase, polypeptide 2 |
|---|
| | ribosomal protein S6 kinase, 70kDa, polypeptide 2 |
|---|
| | Serine/ threonine-protein kinase 14 beta |
|---|
| | 70 kDa ribosomal protein S6 kinase 2 |
|---|
| | p70 ribosomal S6 kinase beta |
|---|
| | Ribosomal protein S6 kinase beta II |
|---|
| | p70 S6K beta |
|---|
| | P70-BETA |
|---|
| | Ribosomal protein S6 kinase beta 2 |
|---|
| | Rps6kb2 |
|---|
| | S6 kinase-related kinase |
|---|
| | S6K2 |
|---|
| | S6K-beta 2 |
|---|
| | STK14B |
|---|
| | p70 ribosomal S6 kinase |
|---|
| | 70 kDa ribosomal protein S6 kinase II |
|---|
| | ribosomal protein S6 kinase, 70kD, polypeptide II |
|---|
| | S6 kinase II |
|---|
| | S6K-beta II |
|---|
| | ribosomal protein S6 kinase, 70kDa, polypeptide II |
|---|
| | ribosomal protein S6 kinase, 70kD, polypeptide 2 |
|---|
| | p70S6Kb |
|---|
| | S6 kinase 2 |
|---|
| | |
|---|
| Organism | Homo sapiens |
|---|
| | Mus musculus |
|---|
| | Human |
|---|
| | |
|---|
| FunctionalClass | kinase |
|---|
| | protein kinase |
|---|
| | protein-tyrosine kinase |
|---|
| | ATP binding |
|---|
| | nucleotide binding |
|---|
| | protein serine/threonine kinase |
|---|
| | transferase |
|---|
| | |
|---|
| KEGG pathway | TGF-beta signaling pathway |
|---|
| | |
|---|
| Cell Localization | Cytoplasm |
|---|
| | |
|---|
| Pathway | Insulin Receptor Signaling |
|---|
| | CB0480 Insulin |
|---|
| | |
|---|
| GO Biological Process | regulation of cell cycle |
|---|
| | protein amino acid phosphorylation |
|---|
| | protein biosynthesis |
|---|
| | regulation of progression through cell cycle |
|---|
| | signal transduction |
|---|
| | |
|---|
| EC Number | 2.7.1.37 |
|---|
| | 2.7.1.- |
|---|
| | |
|---|
| State | isoform B |
|---|
| | isoform A |
|---|
| | |
|---|
| State Description | Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. The resulting protein (isoform b) is shorter and has a distinct C-terminus, compared to isoform a. |
|---|
| | Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
|---|
| | |
|
 |
|
|
