Product | Cat. No. | M.W. | Comments |
ERK Activation Inhibitor I,
Cell-Permeable | | 1757.3 | A stearated 13-amino acids peptide corresponding to the N-terminal of MEK1. Acts as a specific inhibitor of ERK activation and the transcriptional activity of ELK1. Selectively binds to ERK2 and prevents its interaction with MEK (IC50 = 2.5 µM). |
ERK Activation Inhibitor II,
Cell-Permeable | | 3146.8 | A 13-amino acids peptide corresponding to the N-terminal of MEK1 that is fused to the HIV-TAT membrane translocating peptide (MTP) sequence via a glycine linker. Acts as a specific inhibitor of ERK activation and the transcriptional activity of ELK1 by binding to ERK2, and prevents its interaction with MEK (IC50 = 210 nM). |
| ML3163 | | 423.5 | A potent and specific p38 MAP kinase inhibitor (IC50 = 4 µM). Acts by occupying the ATP binding site of p38 MAP kinase. |
| p38 MAP Kinase Inhibitor | | 365.8 | A potent p38 MAP kinase inhibitor (IC50 = 35 nM). |
| PD 98059 | | 267.3 | A potent and selective MEK inhibitor. It selectively blocks the activation of MEK, thus preventing its phosphorylation by cRaf or MEK kinase (IC50 = 2 – 7 µM). |
| PD 169316 | | 360.3 | A potent, and selective p38 MAP kinase inhibitor (IC50 = 89 nM). |
| SB 202474 | | 279.3 | A negative control for MAP kinase inhibition studies. |
| SB 202190 | | 331.3 | A potent, and selective p38 MAP kinase inhibitor (IC50 = 50 nM for SAPK2a/p38 and 100 nM for SAPK2b/p38b2). |
| SB 203580 | | 377.4 | A potent and selective p38 MAP kinase inhibitor (IC50 = 50 nM for SAPK2a/p38 and 500 nM for SAPK2b/p38b2). |
| SB 203580, Sulfone | | 393.4 | The sulfone analog of SB 203580 (Cat. No. 559389). Potently inhibits MAP kinase (IC50 = 30 nM). |
| SB 220025 | | 338.4 | A potent and specific inhibitor of human p38 MAP kinase (IC50 = 60 nM). Displays 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase). |
| SB 239063 | | 368.4 | A potent MAP kinase inhibitor (IC50 = 44 nM for inhibition of recombinant purified human p38a). |
| SC 68376 | | 236.3 | A potent and selective inhibitor of p38 MAP kinase (IC50 = 2 – 5 µM). |
| U0124 | | 226.3 | A useful negative control for MEK inhibitors U0125 (Cat. No. 662008) and U0126 (Cat. No. 662005). |
| U0125 | | 350.5 | A potent and specific inhibitor of MEK1 and MEK2. About 10-fold less potent than U0126 (Cat. No. 662005). |
| U0126 | | 380.5 | A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). |
