 |
|
 |
 |
 |
PKA Interactive Pathway: Protein Kinase A
 | | | PKA Antibodies
|
|
|
|
|
| PhosphoDetect™ Anti-PKA Substrate Mouse mAb (15B12) |
ELISA |
a broad range of species |
539236 |
|
| | | PKA Activators
|
|
|
| Adenosine 3′,5′-cyclic Monophosphate, N6,O2′-Dibutyryl-, Sodium Salt |
28745 |
| Adenosine 3′,5′-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt |
116812 |
| Adenosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt |
203800 |
| Adenosine 3′,5′-cyclic Monophosphate, N6,O2′-Dioctanoyl-, Sodium Salt |
116530 |
| Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt |
116802 |
| Adenosine 3′,5′-cyclic Monophosphate, Sodium Salt |
116801 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt |
116818 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt |
116815 |
| 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Sodium Salt |
287893 |
| 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole 3′,5′-cyclic Monophosphate, Sodium Salt |
287892 |
|
| | | PKA Assay Kits
|
|
|
|
|
|
|
|
|
| Protein Kinase Assay Kit, Non-Radioactive |
96-well plate |
96 Tests |
|
|
|
Cell lysates, purified enzymes |
539484 |
|
| | | PKA Enzymes
|
|
|
| PKA, Catalytic Subunit, Mouse, Recombinant, E. coli |
539481 |
| PKA, His•Tag®, Active, Human, Recombinant, E. coli |
539482 |
|
| | | PKA Inhibitors
|
|
|
| A3, Hydrochloride |
100122 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, 2′-O-Monobutyryl-, Rp-Isomer, Sodium Salt |
116825 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt |
116816 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-2′-monobutyryl-, Rp-Isomer, Sodium Salt |
116813 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt |
116819 |
| Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt |
116814 |
| Biligand Kinase Inhibitor |
201110 |
| 4-Cyano-3-methylisoquinoline |
238900 |
| Daphnetin |
268295 |
| Ellagic Acid, Dihydrate |
324683 |
| H-7, Dihydrochloride |
371955 |
| H-8, Dihydrochloride |
371958 |
| H-9, Dihydrochloride |
371961 |
| H-89, Dihydrochloride |
371963 |
| InSolution™ H-89, Dihydrochloride |
371962 |
| HA 1004, Dihydrochloride |
371964 |
| HA 1077, Dihydrochloride |
371970 |
| K-252a, Nocardiopsis sp. |
420298 |
| InSolution™ K-252a, Nocardiopsis sp. |
420297 |
| K-252b, Nocardiopsis sp. |
420319 |
| KT5720 |
420320 |
| InSolution™ KT5720 |
420323 |
| Piceatannol |
527948 |
| PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated |
476485 |
| PKA Inhibitor 5-24 |
116805 |
| PKA Inhibitor 6-22 Amide |
539684 |
| Staurosporine, Streptomyces sp. |
569397 |
| InSolution™ Staurosporine, Streptomyces sp. |
569396 |
| TX-1123 |
655200 |
|
| | | PKA Substrates
| | | | Additional Information | | | | | | | | |
| Functional Class : PKA
| | | | Name | PKA |
|---|
| Description | cytidine 3',5'-cyclic monophosphate-responsive protein kinase |
|---|
| URN | urn:agi-enz:2.7.1.37 |
|---|
| Total Controls | 0 |
|---|
| Total Nodes | 118 |
|---|
| Total Members | 118 |
|---|
| Notes | A group of enzymes that are under review by the NC-IUBMB. Other present entries are EC 2.7.1.38 (phosphorylase kinase), EC 2.7.1.70 (protamine kinase), EC 2.7.1.99 {[pyruvate dehydrogenase (lipoamide)] kinase}, EC 2.7.1.109 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase), EC 2.7.1.110 (dephospho-[reductase kinase] kinase); EC 2.7.1.112 (protein-tyrosine kinase), EC 2.7.1.115 ([3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase), EC 2.7.1.116 {[isocitrate dehydrogenase (NADP+)] kinase}, EC 2.7.1.123 (Ca2+/calmodulin-dependent protein kinase), EC 2.7.1.124 ([tyrosine 3-monooxygenase] kinase), EC 2.7.1.125 (rhodopsin kinase), EC 2.7.1.126 (beta-adrenergic receptor kinase), EC 2.7.1.135 (tau-protein kinase) and EC 2.7.1.141 ([RNA-polymerase]-subunit kinase). Some enzymes are activated by cyclic GMP, but not by cyclic AMP, and some enzymes are not activated by either. |
|---|
| Connectivity | 2 |
| | | | Cell Localization | Cytoplasm |
| | | | Alias | protein kinase |
|---|
| | phosphorylase b kinase kinase |
|---|
| | glycogen synthase a kinase |
|---|
| | hydroxyalkyl-protein kinase |
|---|
| | serine(threonine) protein kinase |
|---|
| | A-kinase |
|---|
| | AP50 kinase |
|---|
| | ATP-protein transphosphorylase |
|---|
| | betaIIPKC |
|---|
| | beta-andrenergic receptor kinase |
|---|
| | calcium/phospholipid-dependent protein kinase |
|---|
| | calcium-dependent protein kinase C |
|---|
| | cAMP-dependent protein kinase A |
|---|
| | cAMP-dependent protein kinase |
|---|
| | casein kinase |
|---|
| | casein kinase I |
|---|
| | casein kinase II |
|---|
| | casein kinase 2 |
|---|
| | cGMP-dependent protein kinase |
|---|
| | CK-2 |
|---|
| | CKI |
|---|
| | CKII |
|---|
| | cyclic monophosphate-dependent protein kinase |
|---|
| | cyclic AMP-dependent protein kinase |
|---|
| | cyclic AMP-dependent protein kinase A |
|---|
| | cyclic nucleotide-dependent protein kinase |
|---|
| | cyclin-dependent kinase |
|---|
| | cytidine 3',5'-cyclic monophosphate-responsive protein kinase |
|---|
| | epsilon PKC |
|---|
| | glycogen synthase kinase |
|---|
| | Hpr kinase |
|---|
| | protein kinase (phosphorylating) |
|---|
| | casein kinase (phosphorylating) |
|---|
| | MAPK |
|---|
| | mitogen-activated protein kinase |
|---|
| | mitogen-activated S6 kinase |
|---|
| | M phase-specific cdc2 kinase |
|---|
| | p82 kinase |
|---|
| | PKA |
|---|
| | PKC |
|---|
| | protein serine kinase |
|---|
| | protein kinase A |
|---|
| | protein kinase p58 |
|---|
| | protein phosphokinase |
|---|
| | protein glutamyl kinase |
|---|
| | protein serine-threonine kinase |
|---|
| | protein kinase CK2 |
|---|
| | protein-aspartyl kinase |
|---|
| | protein-cysteine kinase |
|---|
| | protein-serine kinase |
|---|
| | Raf kinase |
|---|
| | Raf-1 |
|---|
| | ribosomal S6 protein kinase |
|---|
| | ribosomal protein S6 kinase II |
|---|
| | serine kinase |
|---|
| | serine-specific protein kinase |
|---|
| | serine protein kinase |
|---|
| | serine/threonine protein kinase |
|---|
| | T-antigen kinase |
|---|
| | threonine-specific protein kinase |
|---|
| | twitchin kinase |
|---|
| | type-2 casein kinase |
| | | | Class | Transferases |
|---|
| | Transferring phosphorus-containing groups |
|---|
| | Phosphotransferases with an alcohol group as acceptor |
| | | | Genes | 30811(HUNK) |
|---|
| | 3611(ILK) |
|---|
| | 369(ARAF1) |
|---|
| | 3984(LIMK1) |
|---|
| | 4117(MAK) |
|---|
| | 415116(PIM3) |
|---|
| | 4294(MAP3K10) |
|---|
| | 4342(MOS) |
|---|
| | 472(ATM) |
|---|
| | 4750(NEK1) |
|---|
| | 4751(NEK2) |
|---|
| | 4752(NEK3) |
|---|
| | 5063(PAK3) |
|---|
| | 5127(PCTK1) |
|---|
| | 5128(PCTK2) |
|---|
| | 5170(PDPK1) |
|---|
| | 51755(CRK7) |
|---|
| | 5218(PFTK1) |
|---|
| | 5292(PIM1) |
|---|
| | 5347(PLK1) |
|---|
| | 5566(PRKACA) |
|---|
| | 5567(PRKACB) |
|---|
| | 5568(PRKACG) |
|---|
| | 5578(PRKCA) |
|---|
| | 5579(PRKCB1) |
|---|
| | 5582(PRKCG) |
|---|
| | 5584(PRKCI) |
|---|
| | 5587(PRKD1) |
|---|
| | 5589(PRKCSH) |
|---|
| | 5590(PRKCZ) |
|---|
| | 5591(PRKDC) |
|---|
| | 5592(PRKG1) |
|---|
| | 5593(PRKG2) |
|---|
| | 5594(MAPK1) |
|---|
| | 5596(MAPK4) |
|---|
| | 5597(MAPK6) |
|---|
| | 5598(MAPK7) |
|---|
| | 5599(MAPK8) |
|---|
| | 5600(MAPK11) |
|---|
| | 5601(MAPK9) |
|---|
| | 5602(MAPK10) |
|---|
| | 5603(MAPK13) |
|---|
| | 5613(PRKX) |
|---|
| | 56164(STK31) |
|---|
| | 5681(PSKH1) |
|---|
| | 57396(CLK4) |
|---|
| | 5871(MAP4K2) |
|---|
| | 6195(RPS6KA1) |
|---|
| | 6196(RPS6KA2) |
|---|
| | 6197(RPS6KA3) |
|---|
| | 6300(MAPK12) |
|---|
| | 6446(SGK) |
|---|
| | 65266(PRKWNK4) |
|---|
| | 657(BMPR1A) |
|---|
| | 658(BMPR1B) |
|---|
| | 659(BMPR2) |
|---|
| | 6787(NEK4) |
|---|
| | 6788(STK3) |
|---|
| | 6789(STK4) |
|---|
| | 6790(STK6) |
|---|
| | 6792(CDKL5) |
|---|
| | 6793(STK10) |
|---|
| | 6794(STK11) |
|---|
| | 6795(AURKC) |
|---|
| | 699(BUB1) |
|---|
| | 701(BUB1B) |
|---|
| | 7046(TGFBR1) |
|---|
| | 7048(TGFBR2) |
|---|
| | 7786(MAP3K12) |
|---|
| | 8408(ULK1) |
|---|
| | 8428(STK24) |
|---|
| | 8558(CDK10) |
|---|
| | 8576(STK16) |
|---|
| | 8737(RIPK1) |
|---|
| | 8767(RIPK2) |
|---|
| | 8814(CDKL1) |
|---|
| | 8859(STK19) |
|---|
| | 8899(PRPF4B) |
|---|
| | 8999(CDKL2) |
|---|
| | 90(ACVR1) |
|---|
| | 9020(MAP3K14) |
|---|
| | 91(ACVR1B) |
|---|
| | 92(ACVR2) |
|---|
| | 9212(AURKB) |
|---|
| | 9262(STK17B) |
|---|
| | 9263(STK17A) |
|---|
| | 93(ACVR2B) |
|---|
| | 94(ACVRL1) |
|---|
| | 983(CDC2) |
|---|
| | 9891(ARK5) |
|---|
| | 10000(AKT3) |
|---|
| | 10087(COL4A3BP) |
|---|
| | 10110(SGK2) |
|---|
| | 1017(CDK2) |
|---|
| | 1018(CDK3) |
|---|
| | 1019(CDK4) |
|---|
| | 1020(CDK5) |
|---|
| | 1021(CDK6) |
|---|
| | 1022(CDK7) |
|---|
| | 1024(CDK8) |
|---|
| | 1025(CDK9) |
|---|
| | 10298(PAK4) |
|---|
| | 10494(STK25) |
|---|
| | 10769(PLK2) |
|---|
| | 11035(RIPK3) |
|---|
| | 11040(PIM2) |
|---|
| | 1111(CHEK1) |
|---|
| | 11200(CHEK2) |
|---|
| | 1195(CLK1) |
|---|
| | 1196(CLK2) |
|---|
| | 1198(CLK3) |
|---|
| | 1263(PLK3) |
|---|
| | 140901(STK35) |
|---|
| | 1432(MAPK14) |
|---|
| | 1457(CSNK2A1) |
|---|
| | 1459(CSNK2A2) |
|---|
| | 1460(CSNK2B) |
|---|
| | 1612(DAPK1) |
|---|
| | 208(AKT2) |
|---|
| | 23678(SGKL) |
|---|
| | 26524(LATS2) |
|---|
| | 26576(STK23) |
|---|
| | 269(AMHR2) |
|---|
| | 27102(HRI) |
|---|
| | 27330(RPS6KA6) |
|---|
| | 27347(STK39) |
|---|
| | 2931(GSK3A) |
|---|
| | 2932(GSK3B) |
| | | | Disease | MIM: 115440 Casein kinase-2, alpha-1 polypeptide |
|---|
| | MIM: 115441 Casein kinase-2, beta polypeptide |
|---|
| | MIM: 115442 Casein kinase-2, alpha-prime polypeptide |
|---|
| | MIM: 116940 Cell division cycle 2, G1 to S and G2 to M |
|---|
| | MIM: 116953 Cyclin-dependent kinase 2 |
|---|
| | MIM: 123828 Cyclin-dependent kinase 3 |
|---|
| | MIM: 123829 Cyclin-dependent kinase 4 |
|---|
| | MIM: 123831 Cyclin-dependent kinase 5 |
|---|
| | MIM: 154235 Male germ cell-associated kinase |
|---|
| | MIM: 164731 Murine thymoma viral (v-akt) homolog-2 |
|---|
| | MIM: 176892 Protein kinase, cAMP-dependent, catalytic, beta |
|---|
| | MIM: 176893 Protein kinase, cAMP-dependent, catalytic, gamma |
|---|
| | MIM: 177015 Putative serine kinase H1 |
|---|
| | MIM: 190060 Oncogene MOS, Moloney murine sarcoma virus |
|---|
| | MIM: 190181 Transforming growth factor, beta receptor I (activin A |
|---|
| | receptor type |
|---|
| | MIM: 190182 Transforming growth factor, beta receptor II, 70-80kD |
|---|
| | MIM: 300075 Ribosomal protein S6 kinase, 90kD, polypeptide 3 |
|---|
| | MIM: 300083 Protein kinase, X-linked |
|---|
| | MIM: 300295 Oncogene PIM2 |
|---|
| | MIM: 300303 Ribosomal protein S6 kinase, 90kD, 6 |
|---|
| | MIM: 311010 Oncogene ARAF1 |
|---|
| | MIM: 311550 PCTAIRE protein kinase 1 |
|---|
| | MIM: 600799 Bone morphogenetic receptor, type II |
|---|
| | MIM: 600831 Death-associated protein kinase-1 |
|---|
| | MIM: 600956 Anti-Mullerian hormone receptor, type II |
|---|
| | MIM: 601329 LIM domain kinase 1 |
|---|
| | MIM: 601591 Protein kinase, cGMP-dependent, type II |
|---|
| | MIM: 601639 Protein kinase, cAMP-dependent, catalytic, alpha |
|---|
| | MIM: 601684 Ribosomal protein S6 kinase, 90kD, 1 |
|---|
| | MIM: 601685 Ribosomal protein S6 kinase, 90kD, 2 |
|---|
| | MIM: 601951 CDC-like kinase 1 |
|---|
| | MIM: 601955 Cyclin-dependent kinase 7 (homolog of Xenopus MO15 |
|---|
| | cdk-activating |
|---|
| | MIM: 602216 Serine/threonine protein kinase-11 |
|---|
| | MIM: 602338 Pre-mRNA processing factor 4, yeast, homolog of, B |
|---|
| | MIM: 602366 Integrin-linked kinase |
|---|
| | MIM: 602687 Serine/threonine protein kinase-6 |
|---|
| | MIM: 602730 Activin A receptor, type IIB |
|---|
| | MIM: 602860 Budding uninhibited by benzimidazoles 1, S. |
|---|
| | cerevisiae, homolog of, |
|---|
| | MIM: 602958 Serum/glucocorticoid-regulated kinase |
|---|
| | MIM: 602989 CDC-like kinase 2 |
|---|
| | MIM: 602990 CDC-like kinase 3 |
|---|
| | MIM: 603078 Checkpoint kinase 1, S. pombe, homolog of |
|---|
| | MIM: 603168 UNC51-like kinase 1 |
|---|
| | MIM: 603184 Cyclin-dependent kinase 8 |
|---|
| | MIM: 603248 Bone morphogenetic protein receptor, type IB |
|---|
| | MIM: 603368 Cyclin-dependent kinase 6 |
|---|
| | MIM: 603464 Cyclin-dependent kinase 10 |
|---|
| | MIM: 603919 Serine/threonine protein kinase-10 |
|---|
| | MIM: 604043 Never in mitosis gene a-related kinase 2 |
|---|
| | MIM: 604044 Never in mitosis gene A-related kinase 3 |
|---|
| | MIM: 604655 Mitogen-activated protein kinase kinase kinase-14 |
|---|
| | MIM: 604861 Large tumor suppressor, Drosophila, homolog of, 2 |
|---|
| | MIM: 604965 Serine/threonine protein kinase 4 |
|---|
| | MIM: 604977 Serine/threonine protein kinase 19 |
|---|
| | MIM: 604984 Serine/threonine protein kinase 24 |
|---|
| | MIM: 605004 Glycogen synthase kinase 3-beta |
|---|
| | MIM: 605213 3-phosphoinositide-dependent protein kinase 1 |
|---|
| | MIM: 605451 p21-activated kinase 4 |
|---|
| | MIM: 605790 Serine/threonine kinase 31 |
|---|
| | MIM: 605817 Receptor-interacting serine/threonine kinase 3 |
|---|
| | MIM: 606532 Hormonally upregulated NEU-associated kinase |
|---|
| | MIM: 607589 Serum/glucocorticoid-regulated kinase 2 |
|---|
| | MIM: 607591 Serum/glucocorticoid-regulated kinase-like protein |
|---|
| | MIM: 607648 Serine/threonine protein kinase 39 |
| | | | PDB ID | 1UKI |
|---|
| | 1URC |
|---|
| | 1URW |
|---|
| | 1UTI |
|---|
| | 1UU3 |
|---|
| | 1UU7 |
|---|
| | 1UU8 |
|---|
| | 1UU9 |
|---|
| | 1UV5 |
|---|
| | 1UVR |
|---|
| | 1UWH |
|---|
| | 1UWJ |
|---|
| | 1V1K |
|---|
| | 1VD2 |
|---|
| | 1VJY |
|---|
| | 1VYW |
|---|
| | 1VYZ |
|---|
| | 1VZO |
|---|
| | 1W1D |
|---|
| | 1W1G |
|---|
| | 1W1H |
|---|
| | 1WH4 |
|---|
| | 1WMH |
|---|
| | 1XQZ |
|---|
| | 1XR1 |
|---|
| | 1XTE |
|---|
| | 1XTN |
|---|
| | 1XWS |
|---|
| | 1YDR |
|---|
| | 1YDS |
|---|
| | 1YDT |
|---|
| | 2CPK |
|---|
| | 1APM |
|---|
| | 1AQ1 |
|---|
| | 1ATP |
|---|
| | 1B38 |
|---|
| | 1B39 |
|---|
| | 1B6C |
|---|
| | 1BDY |
|---|
| | 1BKX |
|---|
| | 1BX6 |
|---|
| | 1CDK |
|---|
| | 1CKP |
|---|
| | 1CMK |
|---|
| | 1CTP |
|---|
| | 1DAW |
|---|
| | 1DAY |
|---|
| | 1DDM |
|---|
| | 1DS5 |
|---|
| | 1E1V |
|---|
| | 1E1X |
|---|
| | 1E9H |
|---|
| | 1F0Q |
|---|
| | 1FMO |
|---|
| | 1FOT |
|---|
| | 1FVT |
|---|
| | 1FVV |
|---|
| | 1G3N |
|---|
| | 1GIH |
|---|
| | 1GII |
|---|
| | 1GIJ |
|---|
| | 1GNG |
|---|
| | 1GZ8 |
|---|
| | 1H00 |
|---|
| | 1H01 |
|---|
| | 1H07 |
|---|
| | 1H08 |
|---|
| | 1H0V |
|---|
| | 1H0W |
|---|
| | 1H1W |
|---|
| | 1H8F |
|---|
| | 1HCK |
|---|
| | 1HCL |
|---|
| | 1I09 |
|---|
| | 1IA9 |
|---|
| | 1IAH |
|---|
| | 1IAJ |
|---|
| | 1IAS |
|---|
| | 1ID0 |
|---|
| | 1IK7 |
|---|
| | 1J1B |
|---|
| | 1J1C |
|---|
| | 1J3H |
|---|
| | 1J91 |
|---|
| | 1JAM |
|---|
| | 1JBP |
|---|
| | 1JLU |
|---|
| | 1JVP |
|---|
| | 1JWH |
|---|
| | 1KE5 |
|---|
| | 1KE6 |
|---|
| | 1KE7 |
|---|
| | 1KE8 |
|---|
| | 1KE9 |
|---|
| | 1KTZ |
|---|
| | 1L3R |
|---|
| | 1L6E |
|---|
| | 1LL8 |
|---|
| | 1LP4 |
|---|
| | 1LPU |
|---|
| | 1LR4 |
|---|
| | 1M2P |
|---|
| | 1M2Q |
|---|
| | 1M2R |
|---|
| | 1MBY |
|---|
| | 1NA7 |
|---|
| | 1O6K |
|---|
| | 1O6L |
|---|
| | 1O6Y |
|---|
| | 1O9U |
|---|
| | 1OGU |
|---|
| | 1OI9 |
|---|
| | 1OIQ |
|---|
| | 1OIR |
|---|
| | 1OIT |
|---|
| | 1OIU |
|---|
| | 1OIY |
|---|
| | 1OKU |
|---|
| | 1OKV |
|---|
| | 1OKW |
|---|
| | 1OKY |
|---|
| | 1OKZ |
|---|
| | 1OL1 |
|---|
| | 1OL2 |
|---|
| | 1OL5 |
|---|
| | 1OL6 |
|---|
| | 1OL7 |
|---|
| | 1OM1 |
|---|
| | 1OUK |
|---|
| | 1OUY |
|---|
| | 1OVE |
|---|
| | 1OZ1 |
|---|
| | 1PF8 |
|---|
| | 1PJK |
|---|
| | 1PLO |
|---|
| | 1PY5 |
|---|
| | 1PYX |
|---|
| | 1Q24 |
|---|
| | 1Q3D |
|---|
| | 1Q3W |
|---|
| | 1Q41 |
|---|
| | 1Q4L |
|---|
| | 1Q5K |
|---|
| | 1Q61 |
|---|
| | 1Q62 |
|---|
| | 1Q8T |
|---|
| | 1Q8U |
|---|
| | 1Q8W |
|---|
| | 1QF8 |
|---|
| | 1R0E |
|---|
| | 1R2A |
|---|
| | 1R39 |
|---|
| | 1R3C |
|---|
| | 1RDQ |
|---|
| | 1RE8 |
|---|
| | 1REJ |
|---|
| | 1REK |
|---|
| | 1REW |
|---|
| | 1RGS |
|---|
| | 1RQF |
|---|
| | 1RWI |
|---|
|
| |