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PKA Interactive Pathway: Protein Kinase A
 
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Functional Class : PKA

Name PKA
Description cytidine 3',5'-cyclic monophosphate-responsive protein kinase
URN urn:agi-enz:2.7.1.37
Total Controls 0
Total Nodes 118
Total Members 118
Notes A group of enzymes that are under review by the NC-IUBMB. Other present entries are EC 2.7.1.38 (phosphorylase kinase), EC 2.7.1.70 (protamine kinase), EC 2.7.1.99 {[pyruvate dehydrogenase (lipoamide)] kinase}, EC 2.7.1.109 ([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase), EC 2.7.1.110 (dephospho-[reductase kinase] kinase); EC 2.7.1.112 (protein-tyrosine kinase), EC 2.7.1.115 ([3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase), EC 2.7.1.116 {[isocitrate dehydrogenase (NADP+)] kinase}, EC 2.7.1.123 (Ca2+/calmodulin-dependent protein kinase), EC 2.7.1.124 ([tyrosine 3-monooxygenase] kinase), EC 2.7.1.125 (rhodopsin kinase), EC 2.7.1.126 (beta-adrenergic receptor kinase), EC 2.7.1.135 (tau-protein kinase) and EC 2.7.1.141 ([RNA-polymerase]-subunit kinase). Some enzymes are activated by cyclic GMP, but not by cyclic AMP, and some enzymes are not activated by either.
Connectivity 2

Cell Localization Cytoplasm

Alias protein kinase
phosphorylase b kinase kinase
glycogen synthase a kinase
hydroxyalkyl-protein kinase
serine(threonine) protein kinase
A-kinase
AP50 kinase
ATP-protein transphosphorylase
betaIIPKC
beta-andrenergic receptor kinase
calcium/phospholipid-dependent protein kinase
calcium-dependent protein kinase C
cAMP-dependent protein kinase A
cAMP-dependent protein kinase
casein kinase
casein kinase I
casein kinase II
casein kinase 2
cGMP-dependent protein kinase
CK-2
CKI
CKII
cyclic monophosphate-dependent protein kinase
cyclic AMP-dependent protein kinase
cyclic AMP-dependent protein kinase A
cyclic nucleotide-dependent protein kinase
cyclin-dependent kinase
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
epsilon PKC
glycogen synthase kinase
Hpr kinase
protein kinase (phosphorylating)
casein kinase (phosphorylating)
MAPK
mitogen-activated protein kinase
mitogen-activated S6 kinase
M phase-specific cdc2 kinase
p82 kinase
PKA
PKC
protein serine kinase
protein kinase A
protein kinase p58
protein phosphokinase
protein glutamyl kinase
protein serine-threonine kinase
protein kinase CK2
protein-aspartyl kinase
protein-cysteine kinase
protein-serine kinase
Raf kinase
Raf-1
ribosomal S6 protein kinase
ribosomal protein S6 kinase II
serine kinase
serine-specific protein kinase
serine protein kinase
serine/threonine protein kinase
T-antigen kinase
threonine-specific protein kinase
twitchin kinase
type-2 casein kinase

LocusLink ID 24559
17451
4342
24649
18712
5292
25237
11482
105779
105831
94
5006
25515
18817
5347
25523
19092
100943
5593
25579
116800
117135
22790
26404
7786
25677
17152
4117
29433
18481
4394
5063
29513
58841
20369
26415
5603
29517
20393
6446
29530
11714
110542
209113
269
29591
21812
7046
50686
245619
2931
54237
12534
983
54348
171368
53416
53968
99347
99416
27347
59329
17691
54018
150094
60352
114707
29857
106028
6300
25174
64363
11836
66876
80437
103037
65172
16885
3984
65189
56274
66852
80435
6788
79558
11477
11478
81507
12166
68748
105622
657
81649
12975
26416
1432
81650
13001
1460
257555
257616
81745
18607
5170
28993
81771
20111
6195
81810
21813
76304
102696
7048
83722
20620
10769
84027
56493
56637
66806
78144
98033
2932
94201
12567
1019
84999
92978
114212
50883
11200
114483
12571
1021
116549
12995
12999
1457
140583
12649
97555
1111
140908
12568
100897
1020
246381
362817
12566
353061
1017
25015
300711
11920
472
113978
12167
99604
99865
658
12748
99827
1196
12750
97741
103895
57396
58936
12795
1263
13000
68689
97446
1459
170922
13940
16202
108642
3611
81741
18555
5127
18557
98233
5129
18647
5218
18715
65950
11040
25636
54285
65242
18747
5566
18749
5567
24680
18750
276901
5578
146784
25023
18751
24681
18752
5582
57013
60580
84006
18758
18759
71905
99620
104289
5584
25522
64299
18762
97163
97193
100028
5590
19090
106190
106327
5591
54286
170563
309333
19091
107356
5592
19094
5600
19108
5613
19134
207915
8899
117269
20110
20112
28102
6196
29398
20868
6793
55404
20871
6795
286927
20872
8576
114509
23939
5598
116590
19093
26413
74546
98012
106103
106324
5594
25272
20368
26414
5602
50689
19095
26417
5595
116554
19098
26419
105560
5599
50656
50658
19100
26420
103866
5601
50657
26559
30811
58840
19097
26418
50772
70413
319381
5597
11696
53859
9020
361800
54402
8859
29996
293854
56504
26576
246240
56532
76562
105657
11035
58988
6199
9017
373542
22622
59041
68987
96929
98253
98522
10494
69681
1018
77485
56164
12574
107951
1025
20113
110651
237164
6197
171498
72422
170755
23678
234854
8558
12573
104381
264064
1024
25233
11652
76480
101884
208
12747
98487
1195
171305
12749
102414
235417
1198
28197
69635
76556
105201
1612
26402
108039
269881
269882
4294
16484
18004
52422
382011
4750
114482
18005
96866
98226
4751
23954
4752
220114
18556
76211
107518
109048
237459
5128
5568
18760
5587
54268
225724
5596
102327
244631
5681
23955
6787
8380
22624
58231
98961
99242
6789
200227
261730
20878
99193
99385
6790
110016
270673
382253
6792
20869
97678
103074
6794
29262
360827
22241
100846
8408
223255
8428
27431
192656
8767
71091
8814
53886
100692
320824
8657
8999
114592
20877
101217
9212
170904
76978
98267
9263
77976
103332
103457
9891
171497
27219
98852
99338
10110
51178
70584
101886
10298
27137
114003
15467
100486
100488
27102
67071
27330
192350
69131
109895
193296
23106
51755
287715
69847
193306
8157
65266
84361
67333
140901

EC Number 2.7.1.37

Class Transferases
Transferring phosphorus-containing groups
Phosphotransferases with an alcohol group as acceptor

Genes 30811(HUNK)
3611(ILK)
369(ARAF1)
3984(LIMK1)
4117(MAK)
415116(PIM3)
4294(MAP3K10)
4342(MOS)
472(ATM)
4750(NEK1)
4751(NEK2)
4752(NEK3)
5063(PAK3)
5127(PCTK1)
5128(PCTK2)
5170(PDPK1)
51755(CRK7)
5218(PFTK1)
5292(PIM1)
5347(PLK1)
5566(PRKACA)
5567(PRKACB)
5568(PRKACG)
5578(PRKCA)
5579(PRKCB1)
5582(PRKCG)
5584(PRKCI)
5587(PRKD1)
5589(PRKCSH)
5590(PRKCZ)
5591(PRKDC)
5592(PRKG1)
5593(PRKG2)
5594(MAPK1)
5596(MAPK4)
5597(MAPK6)
5598(MAPK7)
5599(MAPK8)
5600(MAPK11)
5601(MAPK9)
5602(MAPK10)
5603(MAPK13)
5613(PRKX)
56164(STK31)
5681(PSKH1)
57396(CLK4)
5871(MAP4K2)
6195(RPS6KA1)
6196(RPS6KA2)
6197(RPS6KA3)
6300(MAPK12)
6446(SGK)
65266(PRKWNK4)
657(BMPR1A)
658(BMPR1B)
659(BMPR2)
6787(NEK4)
6788(STK3)
6789(STK4)
6790(STK6)
6792(CDKL5)
6793(STK10)
6794(STK11)
6795(AURKC)
699(BUB1)
701(BUB1B)
7046(TGFBR1)
7048(TGFBR2)
7786(MAP3K12)
8408(ULK1)
8428(STK24)
8558(CDK10)
8576(STK16)
8737(RIPK1)
8767(RIPK2)
8814(CDKL1)
8859(STK19)
8899(PRPF4B)
8999(CDKL2)
90(ACVR1)
9020(MAP3K14)
91(ACVR1B)
92(ACVR2)
9212(AURKB)
9262(STK17B)
9263(STK17A)
93(ACVR2B)
94(ACVRL1)
983(CDC2)
9891(ARK5)
10000(AKT3)
10087(COL4A3BP)
10110(SGK2)
1017(CDK2)
1018(CDK3)
1019(CDK4)
1020(CDK5)
1021(CDK6)
1022(CDK7)
1024(CDK8)
1025(CDK9)
10298(PAK4)
10494(STK25)
10769(PLK2)
11035(RIPK3)
11040(PIM2)
1111(CHEK1)
11200(CHEK2)
1195(CLK1)
1196(CLK2)
1198(CLK3)
1263(PLK3)
140901(STK35)
1432(MAPK14)
1457(CSNK2A1)
1459(CSNK2A2)
1460(CSNK2B)
1612(DAPK1)
208(AKT2)
23678(SGKL)
26524(LATS2)
26576(STK23)
269(AMHR2)
27102(HRI)
27330(RPS6KA6)
27347(STK39)
2931(GSK3A)
2932(GSK3B)

Disease MIM: 115440 Casein kinase-2, alpha-1 polypeptide
MIM: 115441 Casein kinase-2, beta polypeptide
MIM: 115442 Casein kinase-2, alpha-prime polypeptide
MIM: 116940 Cell division cycle 2, G1 to S and G2 to M
MIM: 116953 Cyclin-dependent kinase 2
MIM: 123828 Cyclin-dependent kinase 3
MIM: 123829 Cyclin-dependent kinase 4
MIM: 123831 Cyclin-dependent kinase 5
MIM: 154235 Male germ cell-associated kinase
MIM: 164731 Murine thymoma viral (v-akt) homolog-2
MIM: 176892 Protein kinase, cAMP-dependent, catalytic, beta
MIM: 176893 Protein kinase, cAMP-dependent, catalytic, gamma
MIM: 177015 Putative serine kinase H1
MIM: 190060 Oncogene MOS, Moloney murine sarcoma virus
MIM: 190181 Transforming growth factor, beta receptor I (activin A
receptor type
MIM: 190182 Transforming growth factor, beta receptor II, 70-80kD
MIM: 300075 Ribosomal protein S6 kinase, 90kD, polypeptide 3
MIM: 300083 Protein kinase, X-linked
MIM: 300295 Oncogene PIM2
MIM: 300303 Ribosomal protein S6 kinase, 90kD, 6
MIM: 311010 Oncogene ARAF1
MIM: 311550 PCTAIRE protein kinase 1
MIM: 600799 Bone morphogenetic receptor, type II
MIM: 600831 Death-associated protein kinase-1
MIM: 600956 Anti-Mullerian hormone receptor, type II
MIM: 601329 LIM domain kinase 1
MIM: 601591 Protein kinase, cGMP-dependent, type II
MIM: 601639 Protein kinase, cAMP-dependent, catalytic, alpha
MIM: 601684 Ribosomal protein S6 kinase, 90kD, 1
MIM: 601685 Ribosomal protein S6 kinase, 90kD, 2
MIM: 601951 CDC-like kinase 1
MIM: 601955 Cyclin-dependent kinase 7 (homolog of Xenopus MO15
cdk-activating
MIM: 602216 Serine/threonine protein kinase-11
MIM: 602338 Pre-mRNA processing factor 4, yeast, homolog of, B
MIM: 602366 Integrin-linked kinase
MIM: 602687 Serine/threonine protein kinase-6
MIM: 602730 Activin A receptor, type IIB
MIM: 602860 Budding uninhibited by benzimidazoles 1, S.
cerevisiae, homolog of,
MIM: 602958 Serum/glucocorticoid-regulated kinase
MIM: 602989 CDC-like kinase 2
MIM: 602990 CDC-like kinase 3
MIM: 603078 Checkpoint kinase 1, S. pombe, homolog of
MIM: 603168 UNC51-like kinase 1
MIM: 603184 Cyclin-dependent kinase 8
MIM: 603248 Bone morphogenetic protein receptor, type IB
MIM: 603368 Cyclin-dependent kinase 6
MIM: 603464 Cyclin-dependent kinase 10
MIM: 603919 Serine/threonine protein kinase-10
MIM: 604043 Never in mitosis gene a-related kinase 2
MIM: 604044 Never in mitosis gene A-related kinase 3
MIM: 604655 Mitogen-activated protein kinase kinase kinase-14
MIM: 604861 Large tumor suppressor, Drosophila, homolog of, 2
MIM: 604965 Serine/threonine protein kinase 4
MIM: 604977 Serine/threonine protein kinase 19
MIM: 604984 Serine/threonine protein kinase 24
MIM: 605004 Glycogen synthase kinase 3-beta
MIM: 605213 3-phosphoinositide-dependent protein kinase 1
MIM: 605451 p21-activated kinase 4
MIM: 605790 Serine/threonine kinase 31
MIM: 605817 Receptor-interacting serine/threonine kinase 3
MIM: 606532 Hormonally upregulated NEU-associated kinase
MIM: 607589 Serum/glucocorticoid-regulated kinase 2
MIM: 607591 Serum/glucocorticoid-regulated kinase-like protein
MIM: 607648 Serine/threonine protein kinase 39

PDB ID 1UKI
1URC
1URW
1UTI
1UU3
1UU7
1UU8
1UU9
1UV5
1UVR
1UWH
1UWJ
1V1K
1VD2
1VJY
1VYW
1VYZ
1VZO
1W1D
1W1G
1W1H
1WH4
1WMH
1XQZ
1XR1
1XTE
1XTN
1XWS
1YDR
1YDS
1YDT
2CPK
1APM
1AQ1
1ATP
1B38
1B39
1B6C
1BDY
1BKX
1BX6
1CDK
1CKP
1CMK
1CTP
1DAW
1DAY
1DDM
1DS5
1E1V
1E1X
1E9H
1F0Q
1FMO
1FOT
1FVT
1FVV
1G3N
1GIH
1GII
1GIJ
1GNG
1GZ8
1H00
1H01
1H07
1H08
1H0V
1H0W
1H1W
1H8F
1HCK
1HCL
1I09
1IA9
1IAH
1IAJ
1IAS
1ID0
1IK7
1J1B
1J1C
1J3H
1J91
1JAM
1JBP
1JLU
1JVP
1JWH
1KE5
1KE6
1KE7
1KE8
1KE9
1KTZ
1L3R
1L6E
1LL8
1LP4
1LPU
1LR4
1M2P
1M2Q
1M2R
1MBY
1NA7
1O6K
1O6L
1O6Y
1O9U
1OGU
1OI9
1OIQ
1OIR
1OIT
1OIU
1OIY
1OKU
1OKV
1OKW
1OKY
1OKZ
1OL1
1OL2
1OL5
1OL6
1OL7
1OM1
1OUK
1OUY
1OVE
1OZ1
1PF8
1PJK
1PLO
1PY5
1PYX
1Q24
1Q3D
1Q3W
1Q41
1Q4L
1Q5K
1Q61
1Q62
1Q8T
1Q8U
1Q8W
1QF8
1R0E
1R2A
1R39
1R3C
1RDQ
1RE8
1REJ
1REK
1REW
1RGS
1RQF
1RWI