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Protein Kinase Interactive Pathway: CaMK II
 | | |  CaMK II Antibodies
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| Anti-Ca2+/Calmodulin Kinase II, N-Terminal (7-20) Rabbit pAb |
IB |
mouse, rat |
208703 |
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| | | CaMK II Antagonists
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| Calmodulin Binding Domain |
208734 |
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| | | CaMK II Enzymes
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| Ca2+/Calmodulin Kinase II, Rat Brain |
208707 |
| Ca2+/Calmodulin Kinase II, a-Subunit, Rat, Recombinant, Spodoptera frugiperda |
208706 |
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| | | CaMK II Inhibitors
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| Ca2+/Calmodulin Kinase II Inhibitor 281-309 |
208711 |
| [Ala286]-Ca2+/Calmodulin Kinase II Inhibitor 281-301 |
208710 |
| CaMKII Inhibitor, CK59 NEW! |
208922 |
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| | | | Additional Information | | | | | | | | |
| Protein : CAMK2A
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| Connectivity | 73 |
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| Notes | The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. |
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| Hugo ID | 1460 |
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| Name | CAMK2A |
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| Description | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha |
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| URN | urn:agi-llid:815 |
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| GO Cellular Component | calcium- and calmodulin-dependent protein kinase complex |
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| Cell Localization | Cytoplasm |
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| GO Biological Process | protein amino acid phosphorylation |
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| | G1/S transition of mitotic cell cycle |
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| | autophosphorylation |
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| | calcium ion transport |
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| | regulation of neurotransmitter secretion |
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| State | calcium/calmodulin-dependent protein kinase IIA isoform 1 |
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| | calcium/calmodulin-dependent protein kinase IIA isoform 2 |
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| State Description | Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform 1. |
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| | Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2), that is missing an internal segment compared to isoform 1. |
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| Alias | Camk2a |
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| | PKCCD |
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| | PK2CDD |
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| | calcium/calmodulin-dependent protein kinase II alpha subunit |
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| | Ca2+/calmodulin-dependent protein kinase II alpha |
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| | CaMKII |
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| | R74975 |
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| | calcium/calmodulin-dependent protein kinase II alpha |
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| | CaMK II |
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| | alpha-CaMKII |
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| | mKIAA0968 |
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| | CAMKA |
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| | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha |
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| | CaMK-II alpha subunit |
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| | CaM-kinase II alpha chain |
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| | CaM kinase II alpha subunit |
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| | calcium/calmodulin-dependent protein kinase II alpha-B subunit |
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| | calcium/calmodulin-dependent protein kinase type II alpha chain |
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| | KIAA0968 |
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| | calcium/calmodulin-dependent protein kinase (CaM kinase) alpha |
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| | calcium/calmodulin-dependent protein kinase II alpha-B subunit |
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| | calcium/calmodulin-dependent protein kinase IIA isoform 1 |
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| | calcium/calmodulin-dependent protein kinase IIA isoform 2 |
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| | calcium/calmodulin-dependent protein kinase IIA isoform I |
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| | calcium/calmodulin-dependent protein kinase IIA isoform II |
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| | CaMKII alpha |
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| | CaMK-II alpha |
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| | calcium/calmodulin-dependent kinase IIA |
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| | expressed sequence R74975 |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Group | Kinases |
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| | nucleotide binding |
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