Protein : IGF1


Name	IGF1
Description	insulin-like growth factor 1
Owner	Public
URN	urn:agi-llid:3479
Connectivity	423
Notes	The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972 [PubMed 4550398]). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986 [PubMed 3455760]; Rosenfeld, 2003 [PubMed 14657423]).[supplied by OMIM]
Hugo ID	5464


Alias	Igf-1
	Igf-I
	IGFI
	insulin-like growth factor 1a precursor
	Igf1
	IGF-IB
	insulin-like growth factor 1 (somatomedia C)
	Somatomedin C
	insulin-like growth factor 1 (somatomedin C)
	Insulin-like growth factor IB
	C730016P09Rik
	RIKEN cDNA C730016P09 gene
	insulin-like growth factor I
	somatomadin-C/insulin-like growth factor I
	SM-C/IGF-IB
	somatomadin-C/insulin-like growth factor 1
	Igf I
	PIR:A36552
	insulin-like growth factor 1


FunctionalClass	growth factor
	hormone
	insulin-like growth factor receptor binding
	prothoracicotrophic hormone
	protein binding


RGD ID	2868


Hugo Symbol	IGF1


KEGG pathway	Focal adhesion


Cell Localization	Extracellular


Pathway	Control of skeletal myogenesis
	IGF1R -> MYC signalling pathway
	IGF1R -> MYCN signalling pathway
	IGF1R -> HIF1A signalling pathway
	IGF1R -> TP53 signalling pathway
	IGF1R -> ID2 signalling pathway
	IGF1R -> RUNX2 signalling pathway
	IGF1R -> FOXO1A signalling pathway
	IGF1R -> FOS signalling pathway
	IGF1R -> SREBF1 signalling pathway
	IGF1R -> STAT1 signalling pathway
	IGF1R -> STAT3 signalling pathway
	IGF1R -> STAT5A signalling pathway
	IGF1R -> CEBPA signalling pathway
	IGF1R -> CTNNA1 signalling pathway
	IGF1R -> EGR1 signalling pathway
	IGF2R -> ELF4 signalling pathway
	IGF1-BST1
	IGF1-IGF1R
	IGF1-IGF2R
	IGF1-LRP5
	CB0480 Insulin
	simple mTOR


GO Biological Process	anti-apoptosis
	glial cell differentiation
	insulin-like growth factor receptor signaling pathway
	neurogenesis
	organogenesis
	DNA replication
	Ras protein signal transduction
	cell motility
	glycolate metabolism
	muscle development
	perception of sound
	physiological process
	positive regulation of cell proliferation
	signal transduction
	skeletal development


Group	Ligands


MGI ID	96432


Swiss-Prot Accession	P01343


Source	Curated