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Protein Kinase Interactive Pathway: PKA
 
PKA Antibodies
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PhosphoDetect™ Anti-PKA Substrate Mouse mAb (15B12) ELISA a broad range of species 539236
 
PKA Activators
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Adenosine 3′,5′-cyclic Monophosphate, N6,O2′-Dibutyryl-, Sodium Salt 28745
Adenosine 3′,5′-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt 116812
Adenosine 3′,5′-cyclic Monophosphate, 8-Bromo-, Sodium Salt 203800
Adenosine 3′,5′-cyclic Monophosphate, N6,O2′-Dioctanoyl-, Sodium Salt 116530
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt 116802
Adenosine 3′,5′-cyclic Monophosphate, Sodium Salt 116801
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt 116818
Adenosine 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Triethylammonium Salt 116815
5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole 3′,5′-cyclic Monophosphorothioate, Sp-Isomer, Sodium Salt 287893
5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole 3′,5′-cyclic Monophosphate, Sodium Salt 287892
 
PKA Assay Kits
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Protein Kinase Assay Kit, Non-Radioactive 539484
 
PKA Enzymes
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PKA, Catalytic Subunit, Mouse, Recombinant, E. coli 539481
PKA, His•Tag®, Active, Human, Recombinant, E. coli 539482
 
PKA Inhibitors
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A3, Hydrochloride 100122
Adenosine 3′,5′-cyclic Monophosphorothioate, 2′-O-Monobutyryl-, Rp-Isomer, Sodium Salt 116825
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt 116816
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-2′-monobutyryl-, Rp-Isomer, Sodium Salt 116813
Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt 116819
Adenosine 3′,5′-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt 116814
Biligand Kinase Inhibitor 201110
4-Cyano-3-methylisoquinoline 238900
Daphnetin 268295
Ellagic Acid, Dihydrate 324683
H-7, Dihydrochloride 371955
H-8, Dihydrochloride 371958
H-9, Dihydrochloride 371961
H-89, Dihydrochloride 371963
InSolution™ H-89, Dihydrochloride 371962
HA 1004, Dihydrochloride 371964
HA 1077, Dihydrochloride 371970
K-252a, Nocardiopsis sp. 420298
InSolution™ K-252a, Nocardiopsis sp. 420297
K-252b, Nocardiopsis sp. 420319
KT5720 420320
InSolution™ KT5720 420323
Piceatannol 527948
PKA Inhibitor 14-22 Amide, Cell-Permeable, Myristoylated 476485
PKA Inhibitor 5-24 116805
PKA Inhibitor 6-22 Amide 539684
Staurosporine, Streptomyces sp. 569397
InSolution™ Staurosporine, Streptomyces sp. 569396
TX-1123 655200
 
PKA Substrates
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CREBtide 238464
Kemptide 05-23-4900
 
Additional Information
 
 
 
 

Protein : PKA

Connectivity 23
Notes cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Hugo ID 9380
Name PKA
Description protein kinase, cAMP-dependent, catalytic, alpha
URN urn:agi-llid:5566
GO Cellular Component nucleus
cytoplasm
mitochondrion
cAMP-dependent protein kinase complex
Cell Localization Nucleus
Cytoplasm
Mitochondria
GO Biological Process protein amino acid phosphorylation
mesoderm formation
EC Number 2.7.1.37
State cAMP-dependent protein kinase catalytic subunit alpha isoform 1
cAMP-dependent protein kinase catalytic subunit alpha isoform 2
State Description Transcript Variant: This variant (1) encodes the longer isoform (1).
Transcript Variant: This variant (2), also known as variant Cs, uses an alternative exon at the 5' end compared to variant 1, which includes a part of the coding region. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to is...
MGI ID 97592
Swiss-Prot Accession P17612
OMIM ID OMIM:601639
Alias Prkaca
PKCA1
protein kinase, cAMP-dependent, catalytic, alpha
Protein kinase cAMP-dependent catalytic alpha
cAMP-dependent protein kinase catalytic subunit C alpha
Cs
PKA
Pkaca
protein kinase, cAMP dependent, catalytic, alpha
C alpha
KAPA_MOUSE
protein kinase , cAMP-dependent, alpha catalytic chain
PKA C-alpha
protein kinase A catalytic subunit
MGC48865
cAMP-dependent protein kinase, alpha-catalytic subunit
PKCA I
Organism Rattus norvegicus
Mus musculus
Human
LocusLink ID 25636
54285
65242
18747
5566
RGD ID 3389
Unigene ID Rn.103828
Mm.19111
Hs.194350
Group Kinases
nucleotide binding
New Group
 
 
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