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Protein Kinase Interactive Pathway: Adenylate Cyclase
 | | |  Adenylate Cyclase Activators
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| Cholera Toxin, A Subunit, Vibrio cholerae, Type Inaba 569B |
227037 |
| Cholera Toxin, Vibrio cholerae, Type Inaba 569B |
227035 |
| Cholera Toxin, Vibrio cholerae, Type Inaba 569B, Azide Free |
227036 |
| L-(–)-Epinephrine-(+)-bitartrate |
324900 |
| Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-g-butyryl]-, Dihydrochloride |
344273 |
| Forskolin, Coleus forskohlii |
344270 |
| Forskolin, 1,9-Dideoxy-, Coleus forskohlii |
344277 |
| Forskolin, 7-Deacetyl-7-O-hemisuccinyl- |
344275 |
| Isoproterenol, Hydrochloride |
420355 |
| PACAP 27 Amide, Ovine |
05-23-2151 |
| PACAP 38, Ovine |
05-23-2150 |
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| | | Adenylate Cyclase Inhibitors
| | | | Additional Information | | | | | | | | |
| Functional Class : adenylate cyclase
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| Name | adenylate cyclase |
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| Description | 3',5'-cyclic AMP synthetase |
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| URN | urn:agi-enz:4.6.1.1 |
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| Total Controls | 0 |
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| Total Nodes | 11 |
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| Total Members | 11 |
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| Notes | Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+-arginine ADP-ribosyltransferase . |
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| Connectivity | 16 |
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| Cell Localization | Cytoplasm |
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| Alias | adenylate cyclase |
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| | adenylylcyclase |
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| | adenyl cyclase |
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| | 3',5'-cyclic AMP synthetase |
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| Class | Lyases |
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| | Phosphorus-oxygen lyases |
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| Genes | 107(ADCY1) |
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| | 108(ADCY2) |
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| | 109(ADCY3) |
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| | 111(ADCY5) |
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| | 112(ADCY6) |
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| | 113(ADCY7) |
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| | 114(ADCY8) |
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| | 115(ADCY9) |
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| | 196883(ADCY4) |
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| | 55811(SAC) |
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| Disease | MIM: 103070 Adenylyl cyclase-8, brain |
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| | MIM: 103071 Adenylyl cyclase-2, brain |
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| | MIM: 103072 Adenylate cyclase-1, brain |
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| | MIM: 600291 Adenylate cyclase-3 |
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| | MIM: 600292 Adenylate cyclase-4 |
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| | MIM: 600293 Adenylate cyclase-5 |
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| | MIM: 600294 Adenylate cyclase-6 |
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| | MIM: 600385 Adenylate cyclase-7 |
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| | MIM: 603302 Adenylate cyclase-9 |
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| | MIM: 605205 Adenylyl cyclase, soluble |
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| PDB ID | 1AB8 |
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| | 1AZS |
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| | 1CJK |
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| | 1CJT |
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| | 1CJU |
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| | 1CJV |
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| | 1CS4 |
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| | 1CUL |
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| | 1FX2 |
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| | 1FX4 |
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| | 1K8T |
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| | 1K90 |
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| | 1K93 |
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| | 1LVC |
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| | 1PK0 |
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| | 1S26 |
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| | 1SK6 |
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| | 1TL7 |
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| | 1U0H |
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| | 1WC0 |
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| | 1WC1 |
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| | 1WC3 |
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| | 1WC4 |
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| | 1WC5 |
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| | 1WC6 |
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| Reference | Hirata, M. and Hayaishi, O. Adenyl cyclase of Brevibacterium liquefaciens. Biochim. Biophys Acta 149 (1967) 1-11. |
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| DB Link | IUBMB Enzyme Nomenclature: 4.6.1.1 |
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| | ExPASy - ENZYME nomenclature database: 4.6.1.1 |
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| | ERGO genome analysis and discovery system: 4.6.1.1 |
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| | BRENDA, the Enzyme Database: 4.6.1.1 |
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| | CAS: 9012-42-4 |
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