Functional Class : phospholipase C


Name	phospholipase C
Description	Clostridium oedematiens beta- and gamma-toxins
URN	urn:agi-enz:3.1.4.3
Total Controls	0
Total Nodes	18
Total Members	18
Notes	The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.
Connectivity	62


Alias	phospholipase C
	lipophosphodiesterase I
	lecithinase C
	Clostridium welchii alpha-toxin
	Clostridium oedematiens beta- and gamma-toxins
	lipophosphodiesterase C
	phosphatidase C
	heat-labile hemolysin
	alpha-toxin


EC Number	3.1.4.3


Class	Hydrolases
	Acting on ester bonds
	Phosphoric diester hydrolases


PDB ID	1AH7
	1CA1
	1GYG
	1IHJ
	1OLP
	1P5X
	1P6D
	1P6E
	1QM6
	1QMD

Reference

Druzhinina, K.V. and Kritzman, M.G. [Lecithinase from animal tissues.] Biokhimiya 17 (1952) 77-81. (in Russian) 2 [PMID:807246] Little, C. and Otnass, A.-B. The metal ion dependence of phospholipase C from Bacillus cereus. Biochim. Biophys. Acta 391 (1975) 326-333. 3 [PMID:3086312] Sheiknejad, R.G. and Srivastava, P.N. Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma. J. Biol. Chem. 261 (1986) 7544-7549. 4 [PMID:4365891] Takahashi, T., Sugahara, T. and Ohsaka, A. Purification of Clostridium perfringens phospholipase C (alpha-toxin) by affinity chromatography on agarose-linked egg-yolk lipoprotein. Biochim. Biophys. Acta 351 (1974) 155-171.


DB Link	IUBMB Enzyme Nomenclature: 3.1.4.3
	ExPASy - ENZYME nomenclature database: 3.1.4.3
	ERGO genome analysis and discovery system: 3.1.4.3
	BRENDA, the Enzyme Database: 3.1.4.3
	CAS: 9001-86-9


Source	KEGG


CAS ID	9001-86-9

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