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Oxidative Stress Research Tools
 
Oxygen metabolism, although essential for life, imposes a potential threat to cells because of the formation of partially reduced oxygen species.1,2 One electron reduction of oxygen produces superoxide whereas two electron reduction produces hydrogen peroxide. Therefore, electron flow through oxygen, utilizing processes such as the mitochondrial electron transport chain, flavoproteins, cytochrome P450 and oxidases, is tightly coupled to avoid partial reduction of oxygen.3

References
1. Fridovich, I., 1986. Arch. Biochem. Biophys. 247, 1.
2. McCord, J.M., and Fridovich, I. 1988. Free Rad. Biol. Med. 5, 363.
3. Freeman, B.A., and Crapo, J.D. 1982. Lab. Invest. 47, 412.


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