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p53 Interactive Pathway: MRE11
 | | |  MRE11 Antibodies
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| Anti-hMre-11 Rabbit pAb |
IB, IF, IP |
human, mouse, rat |
PC388 |
| Anti-hMre-11 Rabbit pAb |
IB, IF, IP |
human, mouse, rat |
PC388T |
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| | | | Additional Information | | | | | | | | |
| Protein : MRE11A
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| Connectivity | 59 |
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| Notes | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
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| Hugo ID | 7230 |
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| Name | MRE11A |
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| Description | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
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| URN | urn:agi-llid:4361 |
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| GO Cellular Component | nucleus |
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| | nucleoplasm |
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| Cell Localization | Nucleus |
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| GO Biological Process | DNA metabolism |
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| | DNA repair |
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| | double-strand break repair |
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| | meiosis |
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| | transport |
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| | double-strand break repair via nonhomologous end-joining |
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| | meiotic recombination |
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| | regulation of mitotic recombination |
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| | telomerase-dependent telomere maintenance |
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| State | meiotic recombination 11 homolog A isoform 2 |
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| | meiotic recombination 11 homolog A isoform 1 |
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| State Description | Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. Isoform 2 is 28 aa shorter than isoform 1. |
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| | Transcript Variant: This variant (1) encodes the longer isoform of this protein. |
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| Alias | Mre11a |
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| | Mre11 |
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| | meiotic recombination 11 homolog A (S. cerevisiae) |
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| | Mre11b |
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| | ATLD |
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| | HNGS1 |
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| | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
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| | endo/exonuclease Mre11 |
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| | DNA recombination and repair protein |
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| | double-strand break repair protein MRE11A |
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| | meiotic recombination (S. cerevisiae) 11 homolog A |
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| | HNGS I |
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| | meiotic recombination 11 homolog A |
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| | meiotic recombination 11 homolog A isoform 1 |
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| | meiotic recombination 11 homolog A isoform 2 |
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| | meiotic recombination 11 homolog A isoform II |
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| | MRE11 homolog 1 |
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| | MRE11 homolog I |
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| | meiotic recombination 11 (S. cerevisiae) homolog A |
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| Organism | Rattus norvegicus |
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| | Mus musculus |
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| | Human |
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| Group | nucleic acid binding |
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| | metal ion binding |
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