Yellow solid. Supplied as a trifluoroacetate salt. PROTECT FROM MOISTURE. Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-1sec-1 for MMP-2). Purity: ≥95% by HPLC. Excitation max.: ~325 nm, Emission max.: ~393 nm MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl] Ref.: Knight, C.G., et al. 1992. FEBS Lett. 296, 263. |