White to off-white lyophilized solid. Supplied as an acetate salt. PROTECT FROM MOISTURE. N-terminal active peptide fragment of the native hormone that functions as a regulatory factor in the homeostatic control of Ca²⁺ and phosphate metabolism. Regulates Ca²⁺ and phosphate flux across cellular membranes in bone and kidney, resulting in increased serum Ca²⁺ levels. Increases the activity of osteoblasts and osteoclasts. Increases tubular reabsorption of Ca²⁺ and stimulates renal hydroxylation of 25-(OH)-Vitamin D₃ to 1,25-(OH)₂-Vitamin D₃. Increases the production of inhibitory IGF binding protein 4 in bone cells. Purity: ≥95% by HPLC. Sold on the basis of peptide content. CAS 52232-67-4.

H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH

Merck Index: 14, 7034
Ref.: Matsui, H., et al. 1995. Am. J. Physiol. 268, R21. Dua, K., et al. 1994. Exp. Physiol. 79, 401.