N-(3-Aminomethyl)benzylacetamidine, 2HCl White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS. Purity: ≥95% by HPLC. Ref.: Parmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546. Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161. Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733. Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959. Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99. Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300. |
