(2-Aminoethoxy)diphenylborane
2-Aminoethoxydiphenylborate White crystalline solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles. Purity: ≥98% by titration. RTECS ED6150000, CAS 524-95-8. Ref.: Brooke, R. T., et al. 2004. Lab. Invest. 84, 29. Gregory, R.B., et al. 2001. Biochem. J. 354, 285. Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888. Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979. Maruyama, T., et al. 1997. J. Biochem. 122, 498. |
