17DMAG
17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl
17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl
NSC 707545 Purple solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90a with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility. Purity: ≥95% by TLC. Ref.: Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317. Jez, J.M., et al. 2003. Chem. Biol. 10, 361. Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7. |
