ABAP
2,2′-Azobis-(2-amidinopropane), 2HCl
2,2′-Azobis-(2-methylpropionamidine), 2HCl

White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A heat-sensitive, water-soluble, free radical initiator that induces oxidative stress by causing cellular damage associated with lipid peroxidation, protein modification, hemoglobin oxidation, and DNA strand breakage. Reported to induce apoptosis in HL-60 cells via activation of caspase-3. Purity: ≥96% by titration. RTECS UE4575500, CAS 2997-92-4.

Ref.: Ishika, R., et al. 2001. J. Biochem. (Tokyo) 129, 35. Raneva, V., et al. 2001. Lipids 36, 1111. Thomas, M.J., et al. 2001. Biochemistry 40, 1719. Kwon, H.Y., et al. 2000. Biochem. Biophys. Acta 1543, 69. Bassett, C.N., et al. 1999. Lipids 34, 1273. Viner, R.I., et al. 1997. Biochemistry 36, 7706. Kanno, T., et al. 1994. Free Radic. Res. 21, 223.
R: 20/21/22-36/37/38-42/43; S: 26-36