3-O-Acetyl-11-keto-b-Boswellic Acid
AKbBA White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IkBa and inhibit NF-kB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with g-cyclodextrin to facilitate its delivery, AKbBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition. Purity: ≥98% by HPLC. Ref.: Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170. Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223. Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185. Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613. |
