Aggrecanase-2 Inhibitor
5-((4-Chlorobenzylthio-3-trifluoromethyl-N-methyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A thioxothiazolidinone compound that possesses a Zn2+-chelating structural motif and acts as an ADAMTS-5 (aggrecanase-2) inhibitor (IC50 = 1.1 µM) with ~40-fold selectivity over ADAMTS-4 (aggrecanase-1). Purity: ≥97% by HPLC. Ref.: Bursavich, M.G., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1185. Gilbert, A.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1189.
R: 22-36/37/38; S: 36/37 | 
