Dioctanoyl-cAMP, Na Off-white solid. HYGROSCOPIC. Cell-permeable cAMP derivative. Generally mimics the effects of exogenous cAMP but with approximately 100 times greater activity. Highly resistant to the action of phosphodiesterases. Also known to increase the level of inositol trisphosphate in acinar cells. Avoid pH extremes. Purity: ≥95% by TLC. Ref.: Horn, V., et al. 1988. J. Biol. Chem. 263, 12454. Nakamura, H., et al. 1979. J. Biol. Chem. 85, 1321. Pastan, I., and Willingham, M. 1978. Nature 274, 645. Amer, M.S., and McKinney, G.R. 1974. Ann. Reports Med. Chem. 9, 203. Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399. |
