H-TTYADFIASGRTGRRNAIHD
Protein Kinase A Inhibitor 5-24 Lyophilized. Supplied as a trifluoroacetate salt. Sold on the basis of peptide content. HYGROSCOPIC. A potent synthetic peptide that is a competitive inhibitor of protein kinase A (Ki = 2.3 nM). Its sequence is derived from the heat-stable skeletal muscle inhibitor protein of PKA. Binds to the catalytic subunit of PKA and displaces the regulatory subunit. Mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic substrate. Purity: ≥95% by HPLC. Sold on the basis of peptide content. CAS 99534-03-9. H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH Ref.: Knighton, D.R., et al. 1991. Science 253, 525. Cheng, H.C., et al. 1986. J. Biol. Chem. 261, 989. Rusine, T., et al. 1986. J. Cell Biol. 102, 1630. Wong, Y.S., et al. 1986. J. Biol. Chem. 12089. |
