Adenosine 3′,5′-cyclic Phosphorothioate-Sp Sp-cAMPS, TEA Crystalline solid. HYGROSCOPIC. A cell-permeable cAMP analog that binds cAMP-receptor proteins. Induces the guanine-nucleotide exchange factor activity of GEFI (also known as Epac) and GEFII towards Raf1, both in vivo and in vitro. Known to cause a decrease in cytosolic pH. Note: 10 µmol = 4.47 mg. Purity: ≥98% by HPLC. CAS 71774-13-5. Note: 10 µmol = 4.47 mg. Ref.: Kawasaki, H., et al. 1998. Science 282, 2275. de Rooij, J., et al. 1998. Nature 396, 474. Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356. Sugimoto, T., et al. 1992. J. Cell Physiol. 152, 28. Van Der Kloot, W., and Branisteanu, D.D. 1992. Pflugers Arch. 420, 336. Takuma, T., and Ichida, T. 1991. J. Biochem. 110, 292. Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484. Sold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI. |