Rp-8-Cl-cAMPS, Na Lyophilized. HYGROSCOPIC. A cell-permeable, metabolically-stable analog of cAMP that acts as a competitive inhibitor of protein kinase A. Lipophilic analog of the cAMP antagonist Rp-cAMPS (Cat. No. 116814). Preferentially inhibits type I PKA (IC50 = ~50 µM). Purity: ≥98% by HPLC. CAS 142754-27-6. Note: 5 µmol = 2 mg. Ref.: Braun, C.M., et al. 1998. Biochem Pharmacol. 56, 871. Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599. Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.
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