Adenosine 5′-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄

White lyophilized solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg. Purity: ≥95% by HPLC. Note: 1 set = 5 x 60 µg

Ref.: Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886. Slama, J.T., et al. 1995. J. Med. Chem. 38, 389. Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.