ADM 1-52 Lyophilized. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A potent hypotensive peptide hormone with structural similarity to calcitonin gene-related peptide. Inhibits 125I-adrenomedullin binding to specific sites in brain (IC50 = 1.2 nM). Has vasodilatory properties. Suppresses CRF-induced ACTH-release from cultured primary cells. Reported to augment nitric oxide synthase expression in IL-1b -stimulated cardiac myocytes. Purity: ≥95% by HPLC. CAS 148498-78-6. H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 Ref.: Sone, M., et al. 1997. Peptides 18, 1125. Zimmermann, U., et al. 1996. Brain Res. 724, 238. Ikeda, U., et al. 1995. Circulation 94, 2560. Parkes, D.G., and May, C.N. 1995. J. Neuroendocrinol. 7, 923. Kitamura, K., et al. 1993. Biochem. Biophys. Res. Commun. 192, 553.
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