Lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. Induces dose-dependent hypotensive effects that are mediated via binding to specific adrenomedullin-binding sites (Kd = 320 pM) on blood vessels. Has potent platelet cAMP-elevating activity and vasodepressor effects on rat. Purity: ≥98% by HPLC. H-Tyr-Arg-Gln-Ser-Met-Asn-Gln-Gly-Ser-Arg-Ser-Thr-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 Ref.: Nandha, K.A., et al. 1996. Regul. Peptides 62, 145. Kitamura, K., et al. 1993. Biochem. Biophys. Res. Commun. 192, 553. Sakata, J., et al. 1993. Biochem. Biophys. Res. Commun. 195, 921.
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