3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile Off-white to yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation. Purity: ≥98% by HPLC. Ref.: Wen, B., et al. 2001. Br. J. Cancer 85, 2017. Parrizas, M., et al. 1997. Endocrinology 138, 1427. Ohmichi, M., et al. 1993. Biochemistry 32, 4650. |
