w-Aga-TK Lyophilized. Specific P-type calcium channel blocker with no apparent effect on L-type, N-type, and T-type channels. Useful tool for investigating the role of P-type calcium channels in the peripheral and central nervous systems. Also inhibits the release of amino acid transmitters and monoamines. Biological activity: Shown to inhibit K+-induced 3H-GABA release from primary rat hippocampal neurons. Purity: ≥99% by HPLC. CAS 145017-83-0. H-Glu-Asp-Asn-Cys4-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys12-Thr-Trp-Gly-Gly-Thr-Lys-Cys19-Cys20-Arg-Gly-Arg-Pro-Cys25-Arg-Cys27-Ser-Met-Ile-Gly-Thr-Asn-Cys34-Glu-Cys36-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Ser-Phe-Ala-OH (disulfide bonds: 4 → 20; 12 → 25; 19 → 36; 27 → 34) Ref.: Kimura, M., et al. 1995. Neuroscience 66, 609. Teramoto, T., et al. 1995. NeuroReport 6, 1684. Teramoto, T., et al. 1993. Biochem. Biophys. Res. Commun. 196, 134.
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