ARKRERTYSFGHHA Off-white solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. An optimal peptide substrate for assaying Akt/PKB/Rac-protein kinase activity in vitro. The peptide undergoes phosphorylation at the Ser site (Km = 3.9 µM). Competitively inhibits histone H2B phosphorylation (Ki = 12 µM) by Akt. Purity: ≥95% by HPLC. H-Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala-OH Ref.: Obata, T., et al. 2000. J. Biol. Chem. 275, 36108. |